erad Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. (Gene Ontology, GO_0030433)
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Genes

47 genes co-occuring with the biological term erad in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADRM1 adhesion regulating molecule 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APOB apolipoprotein B
ATXN3 ataxin 3
BAG6 BCL2-associated athanogene 6
CANX calnexin
CBX4 chromobox homolog 4
CCDC47 coiled-coil domain containing 47
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHRM3 cholinergic receptor, muscarinic 3
COPG1 coatomer protein complex, subunit gamma 1
CREB3 cAMP responsive element binding protein 3
CREB3L3 cAMP responsive element binding protein 3-like 3
DERL1 derlin 1
DERL2 derlin 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ERLEC1 endoplasmic reticulum lectin 1
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
FBXO6 F-box protein 6
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN1B1 mannosidase, alpha, class 1B, member 1
MAN1C1 mannosidase, alpha, class 1C, member 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
RHO rhodopsin
RNF139 ring finger protein 139
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SELK selenoprotein K
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK2 salt-inducible kinase 2
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SVIP small VCP/p97-interacting protein
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TRA T cell receptor alpha locus
TXNDC16 thioredoxin domain containing 16
UBL4A ubiquitin-like 4A
USP19 ubiquitin specific peptidase 19
USP25 ubiquitin specific peptidase 25
VCP valosin containing protein