erbb2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description erb-b2 receptor tyrosine kinase 2|This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2064)
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Genes

171 genes co-occuring with the biological term erbb2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACHE acetylcholinesterase (Yt blood group)
ACPP acid phosphatase, prostate
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AR androgen receptor
BCAR1 breast cancer anti-estrogen resistance 1
BCAR4 breast cancer anti-estrogen resistance 4 (non-protein coding)
BCL2 B-cell CLL/lymphoma 2
BRCA1 breast cancer 1, early onset
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL23 chemokine (C-C motif) ligand 23
CCND1 cyclin D1
CD151 CD151 molecule (Raph blood group)
CD2AP CD2-associated protein
CDC37 cell division cycle 37
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFL1 cofilin 1 (non-muscle)
COX2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL5 cullin 5
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DOCK7 dedicator of cytokinesis 7
EFNB1 ephrin-B1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ELAVL1 ELAV like RNA binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB2IP erbb2 interacting protein
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERRFI1 ERBB receptor feedback inhibitor 1
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
ETV4 ets variant 4
F2R coagulation factor II (thrombin) receptor
F2RL3 coagulation factor II (thrombin) receptor-like 3
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGF1 fibroblast growth factor 1 (acidic)
FLOT1 flotillin 1
FLOT2 flotillin 2
FOXA1 forkhead box A1
FOXM1 forkhead box M1
FRS3 fibroblast growth factor receptor substrate 3
GAB1 GRB2-associated binding protein 1
GATA4 GATA binding protein 4
GDF15 growth differentiation factor 15
GLS glutaminase
GRB7 growth factor receptor-bound protein 7
HDAC6 histone deacetylase 6
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTT huntingtin
IGF1R insulin-like growth factor 1 receptor
IGKV2-26 immunoglobulin kappa variable 2-26 (pseudogene)
IL2 interleukin 2
ILK integrin-linked kinase
ING5 inhibitor of growth family, member 5
INHA inhibin, alpha
ITGA6 integrin, alpha 6
ITGB4 integrin, beta 4
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KDM1A lysine (K)-specific demethylase 1A
KRAS Kirsten rat sarcoma viral oncogene homolog
LCN2 lipocalin 2
LDHA lactate dehydrogenase A
LEPR leptin receptor
LHCGR luteinizing hormone/choriogonadotropin receptor
LINGO1 leucine rich repeat and Ig domain containing 1
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3
MACF1 microtubule-actin crosslinking factor 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MATK megakaryocyte-associated tyrosine kinase
MET MET proto-oncogene, receptor tyrosine kinase
MFGE8 milk fat globule-EGF factor 8 protein
MIEN1 migration and invasion enhancer 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR125B1 microRNA 125b-1
MIR125B2 microRNA 125b-2
MIR331 microRNA 331
MIR451A microRNA 451a
MIR548D1 microRNA 548d-1
MIR548D2 microRNA 548d-2
MIR559 microRNA 559
MIRLET7B microRNA let-7b
MMP13 matrix metallopeptidase 13
MUC1 mucin 1, cell surface associated
MUC4 mucin 4, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOTCH1 notch 1
NRG1 neuregulin 1
NUPR1 nuclear protein, transcriptional regulator, 1
PA2G4 proliferation-associated 2G4, 38kDa
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARP1 poly (ADP-ribose) polymerase 1
PBOV1 prostate and breast cancer overexpressed 1
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEPD peptidase D
PGAP3 post-GPI attachment to proteins 3
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLAU plasminogen activator, urokinase
PLCG1 phospholipase C, gamma 1
PLXNB1 plexin B1
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRLR prolactin receptor
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTK6 protein tyrosine kinase 6
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRO protein tyrosine phosphatase, receptor type, O
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RHOB ras homolog family member B
RNF11 ring finger protein 11
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
S100A4 S100 calcium binding protein A4
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SH3KBP1 SH3-domain kinase binding protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SMAD4 SMAD family member 4
SPDEF SAM pointed domain containing ETS transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STK11 serine/threonine kinase 11
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TACC1 transforming, acidic coiled-coil containing protein 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF3 trefoil factor 3 (intestinal)
TNF tumor necrosis factor
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOB2 transducer of ERBB2, 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VEGFA vascular endothelial growth factor A
WWOX WW domain containing oxidoreductase
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
YY1 YY1 transcription factor