erbb3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description erb-b2 receptor tyrosine kinase 3|This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2065)
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Genes

45 genes co-occuring with the biological term erbb3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ARF6 ADP-ribosylation factor 6
BMX BMX non-receptor tyrosine kinase
CADM1 cell adhesion molecule 1
CDKN2A cyclin-dependent kinase inhibitor 2A
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FGFR1 fibroblast growth factor receptor 1
FLOT1 flotillin 1
FLOT2 flotillin 2
FOXD3 forkhead box D3
GDF15 growth differentiation factor 15
IGF1R insulin-like growth factor 1 receptor
IRS1 insulin receptor substrate 1
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3
MET MET proto-oncogene, receptor tyrosine kinase
MIR125B1 microRNA 125b-1
MIR205 microRNA 205
MIR22 microRNA 22
MIR451A microRNA 451a
MUC4 mucin 4, cell surface associated
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRG1 neuregulin 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PA2G4 proliferation-associated 2G4, 38kDa
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
SH2B3 SH2B adaptor protein 3
SOST sclerostin
SOX10 SRY (sex determining region Y)-box 10
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
VEGFA vascular endothelial growth factor A
ZNF217 zinc finger protein 217