ercc1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description excision repair cross-complementation group 1|The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 2067)
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Genes

58 genes co-occuring with the biological term ercc1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ALK anaplastic lymphoma receptor tyrosine kinase
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATM ATM serine/threonine kinase
BAG1 BCL2-associated athanogene
BRCA1 breast cancer 1, early onset
BSG basigin (Ok blood group)
CDA cytidine deaminase
CHEK2 checkpoint kinase 2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
FANCD2 Fanconi anemia, complementation group D2
FANCG Fanconi anemia, complementation group G
FAS Fas cell surface death receptor
FGFR2 fibroblast growth factor receptor 2
FLT1 fms-related tyrosine kinase 1
GATA1 GATA binding protein 1 (globin transcription factor 1)
GLI1 GLI family zinc finger 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
ILF3 interleukin enhancer binding factor 3, 90kDa
JUN jun proto-oncogene
LRP1 low density lipoprotein receptor-related protein 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MLH1 mutL homolog 1
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR1H2 nuclear receptor subfamily 1, group H, member 2
OGG1 8-oxoguanine DNA glycosylase
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PMPCB peptidase (mitochondrial processing) beta
PNPT1 polyribonucleotide nucleotidyltransferase 1
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRKCA protein kinase C, alpha
PTEN phosphatase and tensin homolog
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RPA1 replication protein A1, 70kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SNAI1 snail family zinc finger 1
STMN1 stathmin 1
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB3 tubulin, beta 3 class III
TYMS thymidylate synthetase
XPA xeroderma pigmentosum, complementation group A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZNRD1 zinc ribbon domain containing 1