erg Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description v-ets avian erythroblastosis virus E26 oncogene homolog|This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014] (NCBI Entrez Gene Database, 2078)
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Genes

75 genes co-occuring with the biological term erg in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
AIM1 absent in melanoma 1
AMACR alpha-methylacyl-CoA racemase
APLNR apelin receptor
AR androgen receptor
AURKA aurora kinase A
BAALC brain and acute leukemia, cytoplasmic
CD34 CD34 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CLDN5 claudin 5
COL11A2 collagen, type XI, alpha 2
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CSK c-src tyrosine kinase
CTAG1B cancer/testis antigen 1B
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ELF4 E74-like factor 4 (ets domain transcription factor)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV1 ets variant 1
ETV4 ets variant 4
ETV6 ets variant 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR4 fibroblast growth factor receptor 4
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOXP2 forkhead box P2
FZD4 frizzled class receptor 4
GUCA1A guanylate cyclase activator 1A (retina)
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
JUN jun proto-oncogene
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLK3 kallikrein-related peptidase 3
MIR145 microRNA 145
MIR196B microRNA 196b
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NKX3-1 NK3 homeobox 1
NOTCH1 notch 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPY neuropeptide Y
NYX nyctalopin
PECAM1 platelet/endothelial cell adhesion molecule 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PTEN phosphatase and tensin homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPGR retinitis pigmentosa GTPase regulator
RS1 retinoschisin 1
RUNX1 runt-related transcription factor 1
SALL4 spalt-like transcription factor 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
TBX1 T-box 1
TDRD1 tudor domain containing 1
TFF3 trefoil factor 3 (intestinal)
TMED3 transmembrane emp24 protein transport domain containing 3
TMPRSS2 transmembrane protease, serine 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TP63 tumor protein p63
TPX2 TPX2, microtubule-associated
WNT11 wingless-type MMTV integration site family, member 11