A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. (Gene Ontology, GO_0035098)
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10 proteins localized to the esc/e(z) complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.