esculetin-6499 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the esculetin-6499 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALK anaplastic lymphoma receptor tyrosine kinase
ALS2CL ALS2 C-terminal like
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOC4 apolipoprotein C-IV
ASPN asporin
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
C2 complement component 2
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CAPN9 calpain 9
CASP4 caspase 4, apoptosis-related cysteine peptidase
COL4A1 collagen, type IV, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCR4 chemokine (C-X-C motif) receptor 4
DCT dopachrome tautomerase
DCTN2 dynactin 2 (p50)
DGCR8 DGCR8 microprocessor complex subunit
DKFZP434L187 uncharacterized LOC26082
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DTNA dystrobrevin, alpha
EGR3 early growth response 3
EHBP1L1 EH domain binding protein 1-like 1
ELSPBP1 epididymal sperm binding protein 1
FAM182A family with sequence similarity 182, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GLUL glutamate-ammonia ligase
GPER1 G protein-coupled estrogen receptor 1
GPR15 G protein-coupled receptor 15
GRB10 growth factor receptor-bound protein 10
HCAR3 hydroxycarboxylic acid receptor 3
HIRA histone cell cycle regulator
HOMER3 homer scaffolding protein 3
HOXC4 homeobox C4
ICAM1 intercellular adhesion molecule 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INCENP inner centromere protein antigens 135/155kDa
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITGB7 integrin, beta 7
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KRIT1 KRIT1, ankyrin repeat containing
KRT83 keratin 83, type II
LINC00260 long intergenic non-protein coding RNA 260
LMF2 lipase maturation factor 2
LOX lysyl oxidase
LRRC37A3 leucine rich repeat containing 37, member A3
MALL mal, T-cell differentiation protein-like
MAN1A2 mannosidase, alpha, class 1A, member 2
MBD1 methyl-CpG binding domain protein 1
MSI1 musashi RNA-binding protein 1
MST1 macrophage stimulating 1
MTA1 metastasis associated 1
MTRF1L mitochondrial translational release factor 1-like
NOX1 NADPH oxidase 1
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
PARM1 prostate androgen-regulated mucin-like protein 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PLSCR4 phospholipid scramblase 4
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
POU2F3 POU class 2 homeobox 3
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP5C protein phosphatase 5, catalytic subunit
PSG11 pregnancy specific beta-1-glycoprotein 11
PTGDR2 prostaglandin D2 receptor 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAP1GAP RAP1 GTPase activating protein
RBM19 RNA binding motif protein 19
RGS3 regulator of G-protein signaling 3
RPL23AP32 ribosomal protein L23a pseudogene 32
SCNN1B sodium channel, non voltage gated 1 beta subunit
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SETD8 SET domain containing (lysine methyltransferase) 8
SIK3 SIK family kinase 3
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A30 solute carrier family 25, member 30
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNRPN small nuclear ribonucleoprotein polypeptide N
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STOML1 stomatin (EPB72)-like 1
STX1A syntaxin 1A (brain)
TACC1 transforming, acidic coiled-coil containing protein 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TPMT thiopurine S-methyltransferase
TRIL TLR4 interactor with leucine-rich repeats
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP46 ubiquitin specific peptidase 46
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZNF510 zinc finger protein 510
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACAD10 acyl-CoA dehydrogenase family, member 10
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
C8ORF60 chromosome 8 open reading frame 60
C9ORF40 chromosome 9 open reading frame 40
C9ORF9 chromosome 9 open reading frame 9
CAMKMT calmodulin-lysine N-methyltransferase
CAPN1 calpain 1, (mu/I) large subunit
CAPN15 calpain 15
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD82 CD82 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CEP85 centrosomal protein 85kDa
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CIR1 corepressor interacting with RBPJ, 1
CLCN5 chloride channel, voltage-sensitive 5
CNN2 calponin 2
CPPED1 calcineurin-like phosphoesterase domain containing 1
DCAF13 DDB1 and CUL4 associated factor 13
DNAL4 dynein, axonemal, light chain 4
EFCAB2 EF-hand calcium binding domain 2
FAM155A family with sequence similarity 155, member A
FGL1 fibrinogen-like 1
GATA4 GATA binding protein 4
GCHFR GTP cyclohydrolase I feedback regulator
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNL1 guanine nucleotide binding protein-like 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HAMP hepcidin antimicrobial peptide
HMHA1 histocompatibility (minor) HA-1
HOXA4 homeobox A4
HOXC10 homeobox C10
HYI hydroxypyruvate isomerase (putative)
INPP5J inositol polyphosphate-5-phosphatase J
IRF6 interferon regulatory factor 6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JUNB jun B proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM8 lysine (K)-specific demethylase 8
KLF11 Kruppel-like factor 11
KLHL36 kelch-like family member 36
KPNA4 karyopherin alpha 4 (importin alpha 3)
LENEP lens epithelial protein
LIME1 Lck interacting transmembrane adaptor 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMCD1 LIM and cysteine-rich domains 1
LOC100287590 uncharacterized LOC100287590
LOXL3 lysyl oxidase-like 3
LRP2 low density lipoprotein receptor-related protein 2
LRP6 low density lipoprotein receptor-related protein 6
LRRC20 leucine rich repeat containing 20
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED15 mediator complex subunit 15
MICALL2 MICAL-like 2
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MXD3 MAX dimerization protein 3
NECAP2 NECAP endocytosis associated 2
NOL12 nucleolar protein 12
NPM3 nucleophosmin/nucleoplasmin 3
NSD1 nuclear receptor binding SET domain protein 1
PARPBP PARP1 binding protein
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM2 PDZ and LIM domain 2 (mystique)
PODXL2 podocalyxin-like 2
PRF1 perforin 1 (pore forming protein)
PRICKLE3 prickle homolog 3 (Drosophila)
RHBG Rh family, B glycoprotein (gene/pseudogene)
RLN1 relaxin 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF2 ring finger protein 2
RNF25 ring finger protein 25
RPGRIP1L RPGRIP1-like
RPL10L ribosomal protein L10-like
SALL2 spalt-like transcription factor 2
SOX12 SRY (sex determining region Y)-box 12
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNC syncoilin, intermediate filament protein
TBX19 T-box 19
THBS3 thrombospondin 3
TNS2 tensin 2
UPK3B uroplakin 3B
VAV1 vav 1 guanine nucleotide exchange factor
VEGFC vascular endothelial growth factor C
WDR19 WD repeat domain 19
WNT10B wingless-type MMTV integration site family, member 10B
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZFAND3 zinc finger, AN1-type domain 3
ZNF665 zinc finger protein 665
ZNF816 zinc finger protein 816