esr1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description estrogen receptor 1|This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014] (NCBI Entrez Gene Database, 2099)
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Genes

70 genes co-occuring with the biological term esr1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
AICDA activation-induced cytidine deaminase
AR androgen receptor
ATM ATM serine/threonine kinase
BGN biglycan
BRCA1 breast cancer 1, early onset
CCND1 cyclin D1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CETP cholesteryl ester transfer protein, plasma
COMT catechol-O-methyltransferase
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOXC1 forkhead box C1
FSHR follicle stimulating hormone receptor
GSTP1 glutathione S-transferase pi 1
HDAC1 histone deacetylase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOXC4 homeobox C4
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IGF2 insulin-like growth factor 2
IL6 interleukin 6
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
LHCGR luteinizing hormone/choriogonadotropin receptor
LINC-PINT long intergenic non-protein coding RNA, p53 induced transcript
LPL lipoprotein lipase
MAPK3 mitogen-activated protein kinase 3
MIR18A microRNA 18a
MIR222 microRNA 222
MLH1 mutL homolog 1
MTA1 metastasis associated 1
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR2E3 nuclear receptor subfamily 2, group E, member 3
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PGR progesterone receptor
PPARG peroxisome proliferator-activated receptor gamma
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PTEN phosphatase and tensin homolog
PTRH2 peptidyl-tRNA hydrolase 2
RNF31 ring finger protein 31
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SFN stratifin
SP1 Sp1 transcription factor
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SYNE1 spectrin repeat containing, nuclear envelope 1
THRA thyroid hormone receptor, alpha
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XBP1 X-box binding protein 1