esrd Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)|The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. (Experimental Factor Ontology, EFO_0003884)
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Genes

65 genes co-occuring with the biological term esrd in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADD1 adducin 1 (alpha)
ADIPOQ adiponectin, C1Q and collagen domain containing
AGTR1 angiotensin II receptor, type 1
APOE apolipoprotein E
BTBD9 BTB (POZ) domain containing 9
CAT catalase
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
CRP C-reactive protein, pentraxin-related
DUP2Q31.1 Chromosome 2q31.1 duplication syndrome
EDN1 endothelin 1
EFNB2 ephrin-B2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAS Fas cell surface death receptor
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGB fibrinogen beta chain
FGF23 fibroblast growth factor 23
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GHRL ghrelin/obestatin prepropeptide
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
IL10 interleukin 10
IL17A interleukin 17A
IL17RA interleukin 17 receptor A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
INVS inversin
KL klotho
KLK1 kallikrein 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP1 matrix metallopeptidase 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYH9 myosin, heavy chain 9, non-muscle
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NPHP3 nephronophthisis 3 (adolescent)
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPY2R neuropeptide Y receptor Y2
PAX2 paired box 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKD2 polycystic kidney disease 2 (autosomal dominant)
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PRKCB protein kinase C, beta
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SPP1 secreted phosphoprotein 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNNI3 troponin I type 3 (cardiac)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A