estradiol-121 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the estradiol-121 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATG12 autophagy related 12
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BBC3 BCL2 binding component 3
C1QTNF1 C1q and tumor necrosis factor related protein 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCDC71 coiled-coil domain containing 71
CDK12 cyclin-dependent kinase 12
CEND1 cell cycle exit and neuronal differentiation 1
CEP68 centrosomal protein 68kDa
CLCN7 chloride channel, voltage-sensitive 7
CXXC1 CXXC finger protein 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DMTN dematin actin binding protein
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DUS2 dihydrouridine synthase 2
E2F3 E2F transcription factor 3
EFCAB14 EF-hand calcium binding domain 14
EFNB3 ephrin-B3
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EMC1 ER membrane protein complex subunit 1
EPS8L1 EPS8-like 1
ERCC1 excision repair cross-complementation group 1
FANCA Fanconi anemia, complementation group A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FKBP2 FK506 binding protein 2, 13kDa
GALK2 galactokinase 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPR107 G protein-coupled receptor 107
GPX2 glutathione peroxidase 2
GSK3A glycogen synthase kinase 3 alpha
H2AFX H2A histone family, member X
HIST1H3G histone cluster 1, H3g
HLA-G major histocompatibility complex, class I, G
HOXB1 homeobox B1
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IKZF5 IKAROS family zinc finger 5 (Pegasus)
INPP5K inositol polyphosphate-5-phosphatase K
JOSD1 Josephin domain containing 1
KHK ketohexokinase (fructokinase)
LDLR low density lipoprotein receptor
LEMD3 LEM domain containing 3
MAP4 microtubule-associated protein 4
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MT1HL1 metallothionein 1H-like 1
MTFR1 mitochondrial fission regulator 1
MYL10 myosin, light chain 10, regulatory
MYO9B myosin IXB
NFYA nuclear transcription factor Y, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTAN1 N-terminal asparagine amidase
ODF2 outer dense fiber of sperm tails 2
OGFR opioid growth factor receptor
PARM1 prostate androgen-regulated mucin-like protein 1
PEX10 peroxisomal biogenesis factor 10
PGM3 phosphoglucomutase 3
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PLSCR3 phospholipid scramblase 3
PNISR PNN-interacting serine/arginine-rich protein
PPAN peter pan homolog (Drosophila)
PPP1R10 protein phosphatase 1, regulatory subunit 10
PRELP proline/arginine-rich end leucine-rich repeat protein
PRRC2A proline-rich coiled-coil 2A
PYGB phosphorylase, glycogen; brain
QTRT1 queuine tRNA-ribosyltransferase 1
RANBP10 RAN binding protein 10
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RGS12 regulator of G-protein signaling 12
RGS3 regulator of G-protein signaling 3
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC41A3 solute carrier family 41, member 3
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STX12 syntaxin 12
SYF2 SYF2 pre-mRNA-splicing factor
TBRG4 transforming growth factor beta regulator 4
TMEM127 transmembrane protein 127
TMEM161A transmembrane protein 161A
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TTC13 tetratricopeptide repeat domain 13
TTLL4 tubulin tyrosine ligase-like family member 4
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UFSP2 UFM1-specific peptidase 2
VEZF1 vascular endothelial zinc finger 1
VIPR1 vasoactive intestinal peptide receptor 1
WRAP73 WD repeat containing, antisense to TP73
ZBTB22 zinc finger and BTB domain containing 22
ZFHX3 zinc finger homeobox 3
ZNF14 zinc finger protein 14
ZNF35 zinc finger protein 35
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADIRF adipogenesis regulatory factor
AEN apoptosis enhancing nuclease
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARHGAP10 Rho GTPase activating protein 10
ARMC7 armadillo repeat containing 7
ATG14 autophagy related 14
BRAF B-Raf proto-oncogene, serine/threonine kinase
C21ORF91 chromosome 21 open reading frame 91
CALCOCO1 calcium binding and coiled-coil domain 1
CAPG capping protein (actin filament), gelsolin-like
CEP192 centrosomal protein 192kDa
CHEK2 checkpoint kinase 2
CHGB chromogranin B
CNTD2 cyclin N-terminal domain containing 2
CNTNAP1 contactin associated protein 1
CRYL1 crystallin, lambda 1
DENND6B DENN/MADD domain containing 6B
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
EPX eosinophil peroxidase
ERN2 endoplasmic reticulum to nucleus signaling 2
FGF6 fibroblast growth factor 6
FKBP6 FK506 binding protein 6, 36kDa
GDF3 growth differentiation factor 3
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNRH2 gonadotropin-releasing hormone 2
GOLM1 golgi membrane protein 1
GPATCH3 G patch domain containing 3
GPR21 G protein-coupled receptor 21
GRB7 growth factor receptor-bound protein 7
GRIP2 glutamate receptor interacting protein 2
GRM6 glutamate receptor, metabotropic 6
GSTA4 glutathione S-transferase alpha 4
GUCA1B guanylate cyclase activator 1B (retina)
HOXA5 homeobox A5
HOXB2 homeobox B2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL13 interleukin 13
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
ISYNA1 inositol-3-phosphate synthase 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KDM7A lysine (K)-specific demethylase 7A
KIF15 kinesin family member 15
KIF5A kinesin family member 5A
KLHL12 kelch-like family member 12
LEFTY1 left-right determination factor 1
LIMS2 LIM and senescent cell antigen-like domains 2
LMBR1L limb development membrane protein 1-like
LMTK1 lemur tail kinase 1
MIR22HG MIR22 host gene
MNT MAX network transcriptional repressor
NBEAL2 neurobeachin-like 2
NCSTN nicastrin
NDE1 nudE neurodevelopment protein 1
NT5C 5', 3'-nucleotidase, cytosolic
OSGEP O-sialoglycoprotein endopeptidase
OVOL1 ovo-like zinc finger 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
P3H1 prolyl 3-hydroxylase 1
PAQR4 progestin and adipoQ receptor family member IV
PARG poly (ADP-ribose) glycohydrolase
PGP phosphoglycolate phosphatase
PLCD1 phospholipase C, delta 1
POU2F1 POU class 2 homeobox 1
PPOX protoporphyrinogen oxidase
PRLH prolactin releasing hormone
PRMT3 protein arginine methyltransferase 3
PRPH peripherin
PRR4 proline rich 4 (lacrimal)
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PSAT1 phosphoserine aminotransferase 1
RAD54L RAD54-like (S. cerevisiae)
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RANBP17 RAN binding protein 17
SIL1 SIL1 nucleotide exchange factor
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SPEF1 sperm flagellar 1
SQRDL sulfide quinone reductase-like (yeast)
ST5 suppression of tumorigenicity 5
STAC SH3 and cysteine rich domain
STAT4 signal transducer and activator of transcription 4
STX1A syntaxin 1A (brain)
TAS2R1 taste receptor, type 2, member 1
TET3 tet methylcytosine dioxygenase 3
TGFBR1 transforming growth factor, beta receptor 1
TIPRL TOR signaling pathway regulator
TMPRSS6 transmembrane protease, serine 6
TSNAXIP1 translin-associated factor X interacting protein 1
TSPYL2 TSPY-like 2
UNC93B1 unc-93 homolog B1 (C. elegans)
ZNF267 zinc finger protein 267