estradiol-2701 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the estradiol-2701 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C4 aldo-keto reductase family 1, member C4
ANGEL2 angel homolog 2 (Drosophila)
ARHGAP35 Rho GTPase activating protein 35
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BLZF1 basic leucine zipper nuclear factor 1
BMP8B bone morphogenetic protein 8b
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CD84 CD84 molecule
CDY1 chromodomain protein, Y-linked, 1
CEP295 centrosomal protein 295kDa
COL1A2 collagen, type I, alpha 2
CRTC1 CREB regulated transcription coactivator 1
CSNK1G1 casein kinase 1, gamma 1
CXXC4 CXXC finger protein 4
CYHR1 cysteine/histidine-rich 1
DBT dihydrolipoamide branched chain transacylase E2
DCAF17 DDB1 and CUL4 associated factor 17
DGKG diacylglycerol kinase, gamma 90kDa
DIAPH2 diaphanous-related formin 2
DMC1 DNA meiotic recombinase 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DZIP3 DAZ interacting zinc finger protein 3
ELSPBP1 epididymal sperm binding protein 1
EPHB2 EPH receptor B2
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
FAM63B family with sequence similarity 63, member B
FCAR Fc fragment of IgA receptor
FCMR Fc fragment of IgM receptor
FHL1 four and a half LIM domains 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GK3P glycerol kinase 3 pseudogene
HIPK3 homeodomain interacting protein kinase 3
HIST1H3H histone cluster 1, H3h
HPSE2 heparanase 2 (inactive)
ICAM1 intercellular adhesion molecule 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCTD20 potassium channel tetramerization domain containing 20
KIF1C kinesin family member 1C
KIF24 kinesin family member 24
KLHL23 kelch-like family member 23
MDFIC MyoD family inhibitor domain containing
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMRN2 multimerin 2
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NOL10 nucleolar protein 10
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PAIP2B poly(A) binding protein interacting protein 2B
PAPPA2 pappalysin 2
PDLIM3 PDZ and LIM domain 3
PENK proenkephalin
PER3 period circadian clock 3
PHTF2 putative homeodomain transcription factor 2
PIP prolactin-induced protein
PNMAL1 paraneoplastic Ma antigen family-like 1
PRB1 proline-rich protein BstNI subfamily 1
PROL1 proline rich, lacrimal 1
RANBP1 RAN binding protein 1
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASAL2 RAS protein activator like 2
RDX radixin
RPGRIP1L RPGRIP1-like
RPH3A rabphilin 3A
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SIT1 signaling threshold regulating transmembrane adaptor 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A4 solute carrier family 16, member 4
SLC38A7 solute carrier family 38, member 7
SPAG1 sperm associated antigen 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
TAGLN3 transgelin 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TECPR2 tectonin beta-propeller repeat containing 2
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRIM45 tripartite motif containing 45
TTC12 tetratricopeptide repeat domain 12
TTC30A tetratricopeptide repeat domain 30A
UBE3A ubiquitin protein ligase E3A
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBTB1 zinc finger and BTB domain containing 1
ZBTB10 zinc finger and BTB domain containing 10
ZNF174 zinc finger protein 174
ZNF500 zinc finger protein 500
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
ADGB androglobin
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ATAT1 alpha tubulin acetyltransferase 1
BDKRB1 bradykinin receptor B1
BPY2 basic charge, Y-linked, 2
BSPRY B-box and SPRY domain containing
BTF3P12 basic transcription factor 3 pseudogene 12
C14ORF105 chromosome 14 open reading frame 105
C19ORF73 chromosome 19 open reading frame 73
C7ORF69 chromosome 7 open reading frame 69
C8A complement component 8, alpha polypeptide
CA11 carbonic anhydrase XI
CABP2 calcium binding protein 2
CAPN1 calpain 1, (mu/I) large subunit
CCDC92 coiled-coil domain containing 92
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CEMP1 cementum protein 1
CLCN2 chloride channel, voltage-sensitive 2
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPA2 carboxypeptidase A2 (pancreatic)
CPNE7 copine VII
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DNM3 dynamin 3
DPEP2 dipeptidase 2
DSPP dentin sialophosphoprotein
ERC2-IT1 ERC2 intronic transcript 1
FGF23 fibroblast growth factor 23
FGF6 fibroblast growth factor 6
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FSD1 fibronectin type III and SPRY domain containing 1
G0S2 G0/G1 switch 2
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene
GALK1 galactokinase 1
GPR68 G protein-coupled receptor 68
GUCA2A guanylate cyclase activator 2A (guanylin)
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HIST1H1E histone cluster 1, H1e
HIST1H2BI histone cluster 1, H2bi
HIST1H3G histone cluster 1, H3g
HLA-DMA major histocompatibility complex, class II, DM alpha
HOXB9 homeobox B9
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IBSP integrin-binding sialoprotein
IDI2-AS1 IDI2 antisense RNA 1
IQSEC2 IQ motif and Sec7 domain 2
JAM3 junctional adhesion molecule 3
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA1456 KIAA1456
LIME1 Lck interacting transmembrane adaptor 1
LOC100287590 uncharacterized LOC100287590
LY6D lymphocyte antigen 6 complex, locus D
MARC1 mitochondrial amidoxime reducing component 1
MNX1 motor neuron and pancreas homeobox 1
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PADI1 peptidyl arginine deiminase, type I
PBOV1 prostate and breast cancer overexpressed 1
PCDHGA11 protocadherin gamma subfamily A, 11
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PGP phosphoglycolate phosphatase
PLA2G15 phospholipase A2, group XV
PRDM12 PR domain containing 12
PRF1 perforin 1 (pore forming protein)
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
RAB13 RAB13, member RAS oncogene family
RAPSN receptor-associated protein of the synapse
REM1 RAS (RAD and GEM)-like GTP-binding 1
RHOBTB2 Rho-related BTB domain containing 2
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
SCUBE3 signal peptide, CUB domain, EGF-like 3
SFRP5 secreted frizzled-related protein 5
SLC17A2 solute carrier family 17, member 2
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SMR3B submaxillary gland androgen regulated protein 3B
SPATA2L spermatogenesis associated 2-like
SPIDR scaffolding protein involved in DNA repair
STEAP4 STEAP family member 4
SYNPO2L synaptopodin 2-like
TCTN1 tectonic family member 1
TMEM212 transmembrane protein 212
TPM3 tropomyosin 3
VASH1 vasohibin 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VEGFC vascular endothelial growth factor C
VNN1 vanin 1
ZNF10 zinc finger protein 10
ZNF480 zinc finger protein 480
ZNF85 zinc finger protein 85