estradiol-4465 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the estradiol-4465 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ACTC1 actin, alpha, cardiac muscle 1
ADRA1D adrenoceptor alpha 1D
AGFG1 ArfGAP with FG repeats 1
ANKRD12 ankyrin repeat domain 12
APAF1 apoptotic peptidase activating factor 1
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARNT aryl hydrocarbon receptor nuclear translocator
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCL2 B-cell CLL/lymphoma 2
CACFD1 calcium channel flower domain containing 1
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CCNK cyclin K
CD53 CD53 molecule
CDC25C cell division cycle 25C
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CHI3L2 chitinase 3-like 2
CHRDL1 chordin-like 1
COPE coatomer protein complex, subunit epsilon
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV1 ets variant 1
FAS Fas cell surface death receptor
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FKBP10 FK506 binding protein 10, 65 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FRMD8 FERM domain containing 8
GLYAT glycine-N-acyltransferase
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIST1H4F histone cluster 1, H4f
HOXC4 homeobox C4
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INSL4 insulin-like 4 (placenta)
JADE2 jade family PHD finger 2
JAK3 Janus kinase 3
KIAA0232 KIAA0232
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT86 keratin 86, type II
LRP12 low density lipoprotein receptor-related protein 12
LRP4 low density lipoprotein receptor-related protein 4
LRP6 low density lipoprotein receptor-related protein 6
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LY6D lymphocyte antigen 6 complex, locus D
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCF2L MCF.2 cell line derived transforming sequence-like
NCAPH2 non-SMC condensin II complex, subunit H2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
NXPH3 neurexophilin 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSGIN1 oxidative stress induced growth inhibitor 1
PALM paralemmin
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE4DIP phosphodiesterase 4D interacting protein
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
POU4F2 POU class 4 homeobox 2
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRSS53 protease, serine, 53
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTCH1 patched 1
PTCRA pre T-cell antigen receptor alpha
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB31 RAB31, member RAS oncogene family
RFPL2 ret finger protein-like 2
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SCAND2P SCAN domain containing 2 pseudogene
SCN11A sodium channel, voltage gated, type XI alpha subunit
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SNN stannin
SYNDIG1 synapse differentiation inducing 1
SZT2 seizure threshold 2 homolog (mouse)
TBC1D2 TBC1 domain family, member 2
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TTC12 tetratricopeptide repeat domain 12
UST uronyl-2-sulfotransferase
VPRBP Vpr (HIV-1) binding protein
XIST X inactive specific transcript (non-protein coding)
ZIC3 Zic family member 3
ZMYND11 zinc finger, MYND-type containing 11
ZNF343 zinc finger protein 343
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARPIN actin-related protein 2/3 complex inhibitor
BCAS1 breast carcinoma amplified sequence 1
BTNL3 butyrophilin-like 3
C1QB complement component 1, q subcomponent, B chain
C8B complement component 8, beta polypeptide
CD79B CD79b molecule, immunoglobulin-associated beta
CERS4 ceramide synthase 4
CFAP45 cilia and flagella associated protein 45
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CIDEB cell death-inducing DFFA-like effector b
CLIC3 chloride intracellular channel 3
CNGB3 cyclic nucleotide gated channel beta 3
CRMP1 collapsin response mediator protein 1
DDN dendrin
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DNAH17 dynein, axonemal, heavy chain 17
DPY19L1P1 DPY19L1 pseudogene 1
EDAR ectodysplasin A receptor
FAM63A family with sequence similarity 63, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FKBP5 FK506 binding protein 5
FKRP fukutin related protein
GLRA1 glycine receptor, alpha 1
GOLGA6A golgin A6 family, member A
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HAL histidine ammonia-lyase
HAMP hepcidin antimicrobial peptide
HDAC7 histone deacetylase 7
HHLA1 HERV-H LTR-associating 1
HIST1H1D histone cluster 1, H1d
HIST1H2AK histone cluster 1, H2ak
HIST1H2BO histone cluster 1, H2bo
IFT54 intraflagellar transport 54
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL36RN interleukin 36 receptor antagonist
INPP5J inositol polyphosphate-5-phosphatase J
ITGA8 integrin, alpha 8
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLHL25 kelch-like family member 25
KLHL29 kelch-like family member 29
KRT32 keratin 32, type I
KRT9 keratin 9, type I
LAMC3 laminin, gamma 3
LIME1 Lck interacting transmembrane adaptor 1
LYRM9 LYR motif containing 9
MAP3K7CL MAP3K7 C-terminal like
MDM4 MDM4, p53 regulator
MEFV Mediterranean fever
MFAP2 microfibrillar-associated protein 2
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MYOZ1 myozenin 1
MYOZ3 myozenin 3
NAG18 NAG18 mRNA
NIPAL2 NIPA-like domain containing 2
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PICK1 protein interacting with PRKCA 1
PODXL2 podocalyxin-like 2
SCD5 stearoyl-CoA desaturase 5
SCGB2A2 secretoglobin, family 2A, member 2
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMO smoothened, frizzled class receptor
SPATA2L spermatogenesis associated 2-like
SPTBN2 spectrin, beta, non-erythrocytic 2
SULT4A1 sulfotransferase family 4A, member 1
TAOK1 TAO kinase 1
TCP10 t-complex 10
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THRB thyroid hormone receptor, beta
TMEM180 transmembrane protein 180
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
UPK3B uroplakin 3B
VASH1 vasohibin 1
WDR62 WD repeat domain 62
XAF1 XIAP associated factor 1
ZNF214 zinc finger protein 214
ZNF219 zinc finger protein 219
ZNF222 zinc finger protein 222
ZNF234 zinc finger protein 234
ZNF428 zinc finger protein 428