estradiol-5205 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the estradiol-5205 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ACRV1 acrosomal vesicle protein 1
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADCK2 aarF domain containing kinase 2
ADGB androglobin
ADGRE5 adhesion G protein-coupled receptor E5
AKAP4 A kinase (PRKA) anchor protein 4
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGAP33 Rho GTPase activating protein 33
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
C3 complement component 3
C5AR2 complement component 5a receptor 2
CALCR calcitonin receptor
CCDC6 coiled-coil domain containing 6
CCDC64 coiled-coil domain containing 64
CD83 CD83 molecule
CDON cell adhesion associated, oncogene regulated
CFAP70 cilia and flagella associated protein 70
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLCN7 chloride channel, voltage-sensitive 7
COL1A1 collagen, type I, alpha 1
CSPP1 centrosome and spindle pole associated protein 1
CTBP2 C-terminal binding protein 2
CXCR2 chemokine (C-X-C motif) receptor 2
DPF1 D4, zinc and double PHD fingers family 1
EGR3 early growth response 3
ETV5 ets variant 5
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM46C family with sequence similarity 46, member C
FCMR Fc fragment of IgM receptor
FLJ22184
FLOT1 flotillin 1
GPATCH4 G patch domain containing 4
GPR143 G protein-coupled receptor 143
GREB1L growth regulation by estrogen in breast cancer-like
HOXB2 homeobox B2
IDS iduronate 2-sulfatase
IL12RB1 interleukin 12 receptor, beta 1
IL6ST interleukin 6 signal transducer
ITPK1 inositol-tetrakisphosphate 1-kinase
JAK2 Janus kinase 2
JUN jun proto-oncogene
KIF26B kinesin family member 26B
KLF2 Kruppel-like factor 2
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1
LMF2 lipase maturation factor 2
LOXL3 lysyl oxidase-like 3
LPIN2 lipin 2
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MBD1 methyl-CpG binding domain protein 1
MCAM melanoma cell adhesion molecule
MEGF9 multiple EGF-like-domains 9
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTMR7 myotubularin related protein 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NUP214 nucleoporin 214kDa
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PDLIM3 PDZ and LIM domain 3
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PITX2 paired-like homeodomain 2
PKNOX2 PBX/knotted 1 homeobox 2
PLCH1 phospholipase C, eta 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRKCE protein kinase C, epsilon
PTGDR2 prostaglandin D2 receptor 2
RGS10 regulator of G-protein signaling 10
RGS12 regulator of G-protein signaling 12
RTEL1 regulator of telomere elongation helicase 1
S100A7 S100 calcium binding protein A7
SDC3 syndecan 3
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOGA1 suppressor of glucose, autophagy associated 1
SPAG6 sperm associated antigen 6
SRF serum response factor (c-fos serum response element-binding transcription factor)
SUGP1 SURP and G patch domain containing 1
TMPRSS15 transmembrane protease, serine 15
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TPST2 tyrosylprotein sulfotransferase 2
TRIM21 tripartite motif containing 21
TUBA3C tubulin, alpha 3c
TUBB2B tubulin, beta 2B class IIb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UHRF1BP1L UHRF1 binding protein 1-like
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
YY2 YY2 transcription factor
ZFP64 ZFP64 zinc finger protein
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABHD4 abhydrolase domain containing 4
ARPIN actin-related protein 2/3 complex inhibitor
BAG4 BCL2-associated athanogene 4
BAK1 BCL2-antagonist/killer 1
BPGM 2,3-bisphosphoglycerate mutase
C1ORF35 chromosome 1 open reading frame 35
C7ORF43 chromosome 7 open reading frame 43
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CEP170B centrosomal protein 170B
CFAP44 cilia and flagella associated protein 44
CLCN6 chloride channel, voltage-sensitive 6
CLMN calmin (calponin-like, transmembrane)
CLSTN2 calsyntenin 2
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
DDIT3 DNA-damage-inducible transcript 3
DNAL4 dynein, axonemal, light chain 4
DVL1 dishevelled segment polarity protein 1
DYSF dysferlin
EFNA1 ephrin-A1
EPN3 epsin 3
ERCC4 excision repair cross-complementation group 4
FBRS fibrosin
FBXL6 F-box and leucine-rich repeat protein 6
FBXO31 F-box protein 31
FER fer (fps/fes related) tyrosine kinase
FSTL3 follistatin-like 3 (secreted glycoprotein)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
HIST1H2AI histone cluster 1, H2ai
HIST1H2BO histone cluster 1, H2bo
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMBOX1 homeobox containing 1
HOXC10 homeobox C10
HOXC13 homeobox C13
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF9 interferon regulatory factor 9
KCTD7 potassium channel tetramerization domain containing 7
KIAA0513 KIAA0513
KIF13B kinesin family member 13B
LIN7B lin-7 homolog B (C. elegans)
MED15 mediator complex subunit 15
MFSD12 major facilitator superfamily domain containing 12
MGC12488
MTA2 metastasis associated 1 family, member 2
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MXD3 MAX dimerization protein 3
NPIPB3 nuclear pore complex interacting protein family, member B3
NUAK1 NUAK family, SNF1-like kinase, 1
OLFML3 olfactomedin-like 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PADI1 peptidyl arginine deiminase, type I
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PMM1 phosphomannomutase 1
PNPLA6 patatin-like phospholipase domain containing 6
PRR15L proline rich 15-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RASAL1 RAS protein activator like 1 (GAP1 like)
RNF43 ring finger protein 43
RPGR retinitis pigmentosa GTPase regulator
SCRN3 secernin 3
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SENP7 SUMO1/sentrin specific peptidase 7
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIX1 SIX homeobox 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLIT2 slit homolog 2 (Drosophila)
SLMO1 slowmo homolog 1 (Drosophila)
SMR3A submaxillary gland androgen regulated protein 3A
SPRY2 sprouty homolog 2 (Drosophila)
STON1 stonin 1
STRA6 stimulated by retinoic acid 6
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
THRAP3 thyroid hormone receptor associated protein 3
TMEM121 transmembrane protein 121
TMEM53 transmembrane protein 53
TNS2 tensin 2
TOM1 target of myb1 (chicken)
TPRA1 transmembrane protein, adipocyte asscociated 1
TRAIP TRAF interacting protein
TRAPPC6A trafficking protein particle complex 6A
TRIM25 tripartite motif containing 25
TRIM45 tripartite motif containing 45
TUBG2 tubulin, gamma 2
UPK3B uroplakin 3B
WDR91 WD repeat domain 91
XYLT1 xylosyltransferase I
ZBTB44 zinc finger and BTB domain containing 44
ZNF282 zinc finger protein 282
ZNF34 zinc finger protein 34
ZNF446 zinc finger protein 446