estradiol-5238 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the estradiol-5238 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACAN aggrecan
ADCY9 adenylate cyclase 9
AGFG1 ArfGAP with FG repeats 1
AHCYL2 adenosylhomocysteinase-like 2
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C1 aldo-keto reductase family 1, member C1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APC adenomatous polyposis coli
ARC activity-regulated cytoskeleton-associated protein
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ASPH aspartate beta-hydroxylase
BGLAP bone gamma-carboxyglutamate (gla) protein
C17ORF59 chromosome 17 open reading frame 59
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CD83 CD83 molecule
CD8A CD8a molecule
CHD9 chromodomain helicase DNA binding protein 9
CLCN7 chloride channel, voltage-sensitive 7
COL1A1 collagen, type I, alpha 1
DFNB31 deafness, autosomal recessive 31
DLC1 DLC1 Rho GTPase activating protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOCK6 dedicator of cytokinesis 6
ECE1 endothelin converting enzyme 1
EGR3 early growth response 3
EIF5A2 eukaryotic translation initiation factor 5A2
FCMR Fc fragment of IgM receptor
FGF16 fibroblast growth factor 16
FHL1 four and a half LIM domains 1
FLJ42627 uncharacterized LOC645644
FRK fyn-related Src family tyrosine kinase
GAP43 growth associated protein 43
GPR137 G protein-coupled receptor 137
GSPT1 G1 to S phase transition 1
HEG1 heart development protein with EGF-like domains 1
HHAT hedgehog acyltransferase
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
IL18 interleukin 18
ITGB5 integrin, beta 5
JAK2 Janus kinase 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNK5 potassium channel, two pore domain subfamily K, member 5
KIAA0125 KIAA0125
KPNA5 karyopherin alpha 5 (importin alpha 6)
LRP12 low density lipoprotein receptor-related protein 12
LRRC20 leucine rich repeat containing 20
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MED9 mediator complex subunit 9
MMP12 matrix metallopeptidase 12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NME5 NME/NM23 family member 5
NOD1 nucleotide-binding oligomerization domain containing 1
NPY5R neuropeptide Y receptor Y5
PAX2 paired box 2
PEX11A peroxisomal biogenesis factor 11 alpha
PGR progesterone receptor
PHKA2 phosphorylase kinase, alpha 2 (liver)
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRSS22 protease, serine, 22
PSG9 pregnancy specific beta-1-glycoprotein 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
RAB6B RAB6B, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RUNDC3A RUN domain containing 3A
RUSC2 RUN and SH3 domain containing 2
SAMD9 sterile alpha motif domain containing 9
SDC3 syndecan 3
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH3GL3 SH3-domain GRB2-like 3
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNTG1 syntrophin, gamma 1
SNX13 sorting nexin 13
SOCS6 suppressor of cytokine signaling 6
SPRR2B small proline-rich protein 2B
SRSF1 serine/arginine-rich splicing factor 1
SRSF7 serine/arginine-rich splicing factor 7
SYBU syntabulin (syntaxin-interacting)
TCP11L1 t-complex 11, testis-specific-like 1
THBS1 thrombospondin 1
TLDC1 TBC/LysM-associated domain containing 1
TMEM8B transmembrane protein 8B
TNPO2 transportin 2
TRBC1 T cell receptor beta constant 1
TUBA3D tubulin, alpha 3d
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative)
UCN urocortin
USP2 ubiquitin specific peptidase 2
UTS2 urotensin 2
WDR62 WD repeat domain 62
ZCCHC11 zinc finger, CCHC domain containing 11
ZMAT4 zinc finger, matrin-type 4
ZNF492 zinc finger protein 492

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACSF2 acyl-CoA synthetase family member 2
ALPK1 alpha-kinase 1
ARPIN actin-related protein 2/3 complex inhibitor
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BFSP1 beaded filament structural protein 1, filensin
BLNK B-cell linker
BMP4 bone morphogenetic protein 4
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C11ORF63 chromosome 11 open reading frame 63
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDKL3 cyclin-dependent kinase-like 3
CHKB choline kinase beta
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CPTP ceramide-1-phosphate transfer protein
CUL9 cullin 9
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DTX4 deltex 4, E3 ubiquitin ligase
EFNA1 ephrin-A1
EFNA3 ephrin-A3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
FAM204A family with sequence similarity 204, member A
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FSD1 fibronectin type III and SPRY domain containing 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GRPR gastrin-releasing peptide receptor
GSTTP1 glutathione S-transferase theta pseudogene 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUSBP3 glucuronidase, beta pseudogene 3
HDAC5 histone deacetylase 5
HIST1H2AJ histone cluster 1, H2aj
HOXA4 homeobox A4
HOXC13 homeobox C13
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IPO8 importin 8
IRF6 interferon regulatory factor 6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCTD7 potassium channel tetramerization domain containing 7
KDM5C lysine (K)-specific demethylase 5C
KIF13B kinesin family member 13B
KLC2 kinesin light chain 2
KLF7 Kruppel-like factor 7 (ubiquitous)
LARP6 La ribonucleoprotein domain family, member 6
LINC00339 long intergenic non-protein coding RNA 339
MRPS18C mitochondrial ribosomal protein S18C
MTRF1 mitochondrial translational release factor 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NDE1 nudE neurodevelopment protein 1
NOL12 nucleolar protein 12
NPIPB15 nuclear pore complex interacting protein family, member B15
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PADI1 peptidyl arginine deiminase, type I
PDE8B phosphodiesterase 8B
POPDC3 popeye domain containing 3
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRR14L proline rich 14-like
QPCT glutaminyl-peptide cyclotransferase
RAD54L2 RAD54-like 2 (S. cerevisiae)
RFTN1 raftlin, lipid raft linker 1
RPL13P5 ribosomal protein L13 pseudogene 5
SHARPIN SHANK-associated RH domain interactor
SKI SKI proto-oncogene
SLC22A14 solute carrier family 22, member 14
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLIT2 slit homolog 2 (Drosophila)
SMR3A submaxillary gland androgen regulated protein 3A
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STON1 stonin 1
SUN2 Sad1 and UNC84 domain containing 2
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBX19 T-box 19
TEP1 telomerase-associated protein 1
TMEM212 transmembrane protein 212
TWSG1 twisted gastrulation BMP signaling modulator 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR76 WD repeat domain 76
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZBTB44 zinc finger and BTB domain containing 44
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF205 zinc finger protein 205
ZNF329 zinc finger protein 329
ZNF350 zinc finger protein 350
ZNF394 zinc finger protein 394
ZNF446 zinc finger protein 446
ZNF480 zinc finger protein 480
ZNF532 zinc finger protein 532
ZNF652 zinc finger protein 652
ZNF747 zinc finger protein 747
ZNF750 zinc finger protein 750
ZNRD1-AS1 ZNRD1 antisense RNA 1