estradiol-5568 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the estradiol-5568 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADD2 adducin 2 (beta)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALOX5 arachidonate 5-lipoxygenase
ALOXE3 arachidonate lipoxygenase 3
AMPD3 adenosine monophosphate deaminase 3
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APC adenomatous polyposis coli
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
AQP3 aquaporin 3 (Gill blood group)
ARTN artemin
ASB1 ankyrin repeat and SOCS box containing 1
ATAT1 alpha tubulin acetyltransferase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP11A ATPase, class VI, type 11A
BTNL3 butyrophilin-like 3
C1ORF54 chromosome 1 open reading frame 54
C8A complement component 8, alpha polypeptide
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCNT2 cyclin T2
CD47 CD47 molecule
CDC42 cell division cycle 42
CDKN2A cyclin-dependent kinase inhibitor 2A
CEMIP cell migration inducing protein, hyaluronan binding
COL2A1 collagen, type II, alpha 1
COL4A6 collagen, type IV, alpha 6
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPF1 D4, zinc and double PHD fingers family 1
EGR3 early growth response 3
ELAVL3 ELAV like neuron-specific RNA binding protein 3
FADS3 fatty acid desaturase 3
FZD7 frizzled class receptor 7
GLS glutaminase
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GM2A GM2 ganglioside activator
GTPBP1 GTP binding protein 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HUS1 HUS1 checkpoint homolog (S. pombe)
ING2 inhibitor of growth family, member 2
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIAA0485 uncharacterized LOC57235
KIF25-AS1 KIF25 antisense RNA 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOB monoamine oxidase B
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MVB12B multivesicular body subunit 12B
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NAT6 N-acetyltransferase 6 (GCN5-related)
NPY1R neuropeptide Y receptor Y1
PAPPA2 pappalysin 2
PARVA parvin, alpha
PCDHB6 protocadherin beta 6
PDZK1 PDZ domain containing 1
PHC3 polyhomeotic homolog 3 (Drosophila)
PLCD1 phospholipase C, delta 1
PTH1R parathyroid hormone 1 receptor
PWAR5 Prader Willi/Angelman region RNA 5
RFPL1S RFPL1 antisense RNA 1
RGS10 regulator of G-protein signaling 10
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPLP2 ribosomal protein, large, P2
RUNDC3A RUN domain containing 3A
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCNN1B sodium channel, non voltage gated 1 beta subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SKI SKI proto-oncogene
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SNX29P2 sorting nexin 29 pseudogene 2
SOS2 son of sevenless homolog 2 (Drosophila)
SPPL2B signal peptide peptidase like 2B
STAC SH3 and cysteine rich domain
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK17A serine/threonine kinase 17a
SYBU syntabulin (syntaxin-interacting)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFA transforming growth factor, alpha
TGM2 transglutaminase 2
TP63 tumor protein p63
TSC22D3 TSC22 domain family, member 3
TUBA4B tubulin, alpha 4b
USP9Y ubiquitin specific peptidase 9, Y-linked
VEGFA vascular endothelial growth factor A
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WIPF1 WAS/WASL interacting protein family, member 1

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADGRE5 adhesion G protein-coupled receptor E5
AHNAK2 AHNAK nucleoprotein 2
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANXA2P3 annexin A2 pseudogene 3
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARR3 arrestin 3, retinal (X-arrestin)
ARRB1 arrestin, beta 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAX BCL2-associated X protein
C14ORF93 chromosome 14 open reading frame 93
C22ORF46 chromosome 22 open reading frame 46
C5AR2 complement component 5a receptor 2
C8ORF60 chromosome 8 open reading frame 60
CAPN5 calpain 5
CCDC69 coiled-coil domain containing 69
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CPNE7 copine VII
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EFNA3 ephrin-A3
EXD3 exonuclease 3'-5' domain containing 3
FBRS fibrosin
FGF6 fibroblast growth factor 6
FHIT fragile histidine triad
FKBP10 FK506 binding protein 10, 65 kDa
FLJ11710 uncharacterized protein FLJ11710
FRMD1 FERM domain containing 1
FURIN furin (paired basic amino acid cleaving enzyme)
FZD4 frizzled class receptor 4
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAMT guanidinoacetate N-methyltransferase
GMPR guanosine monophosphate reductase
GUSBP3 glucuronidase, beta pseudogene 3
HDAC5 histone deacetylase 5
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOXA4 homeobox A4
HPS6 Hermansky-Pudlak syndrome 6
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
INO80D INO80 complex subunit D
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNIP1 Kv channel interacting protein 1
KLF2 Kruppel-like factor 2
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LIN7A lin-7 homolog A (C. elegans)
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MATK megakaryocyte-associated tyrosine kinase
MFAP2 microfibrillar-associated protein 2
MICALL2 MICAL-like 2
NACA2 nascent polypeptide-associated complex alpha subunit 2
NTF3 neurotrophin 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
ONECUT2 one cut homeobox 2
OSGIN1 oxidative stress induced growth inhibitor 1
PADI1 peptidyl arginine deiminase, type I
PARD6A par-6 family cell polarity regulator alpha
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLSCR4 phospholipid scramblase 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPAP1 RNA polymerase II associated protein 1
RPL10L ribosomal protein L10-like
RPL23AP32 ribosomal protein L23a pseudogene 32
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A9 S100 calcium binding protein A9
SAA4 serum amyloid A4, constitutive
SAYSD1 SAYSVFN motif domain containing 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLIT2 slit homolog 2 (Drosophila)
SLMO1 slowmo homolog 1 (Drosophila)
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMIM14 small integral membrane protein 14
SREK1IP1 SREK1-interacting protein 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TEP1 telomerase-associated protein 1
TGFBR3 transforming growth factor, beta receptor III
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TIGD6 tigger transposable element derived 6
TNS2 tensin 2
TRAIP TRAF interacting protein
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSC22D4 TSC22 domain family, member 4
UNC93B1 unc-93 homolog B1 (C. elegans)
VASH2 vasohibin 2
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIM vimentin
WDR62 WD repeat domain 62
ZFHX2 zinc finger homeobox 2
ZNF204P zinc finger protein 204, pseudogene
ZNF205 zinc finger protein 205
ZNF248 zinc finger protein 248
ZNF446 zinc finger protein 446
ZNF639 zinc finger protein 639
ZNF862 zinc finger protein 862