estradiol-5905 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the estradiol-5905 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADAM22 ADAM metallopeptidase domain 22
ADGRA2 adhesion G protein-coupled receptor A2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP9B ATPase, class II, type 9B
CADM3 cell adhesion molecule 3
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2
CD22 CD22 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CELF2 CUGBP, Elav-like family member 2
CEP295 centrosomal protein 295kDa
CFAP69 cilia and flagella associated protein 69
CRTC1 CREB regulated transcription coactivator 1
CYHR1 cysteine/histidine-rich 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DFNB31 deafness, autosomal recessive 31
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
DTNA dystrobrevin, alpha
EGR3 early growth response 3
EPHB2 EPH receptor B2
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV7 ets variant 7
F2RL3 coagulation factor II (thrombin) receptor-like 3
FAM182B family with sequence similarity 182, member B
FHL1 four and a half LIM domains 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GJB3 gap junction protein, beta 3, 31kDa
GNAS GNAS complex locus
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HFE hemochromatosis
HLA-C major histocompatibility complex, class I, C
IL11RA interleukin 11 receptor, alpha
IQCC IQ motif containing C
JAK2 Janus kinase 2
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KLF2 Kruppel-like factor 2
KRT6B keratin 6B, type II
LTC4S leukotriene C4 synthase
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MBNL2 muscleblind-like splicing regulator 2
MCM3AP minichromosome maintenance complex component 3 associated protein
MED25 mediator complex subunit 25
MET MET proto-oncogene, receptor tyrosine kinase
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MLANA melan-A
MST1 macrophage stimulating 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFX1 nuclear transcription factor, X-box binding 1
PADI1 peptidyl arginine deiminase, type I
PADI3 peptidyl arginine deiminase, type III
PDE5A phosphodiesterase 5A, cGMP-specific
PGAM2 phosphoglycerate mutase 2 (muscle)
PLAT plasminogen activator, tissue
PLEKHS1 pleckstrin homology domain containing, family S member 1
PML promyelocytic leukemia
PODNL1 podocan-like 1
PPP5C protein phosphatase 5, catalytic subunit
PRSS53 protease, serine, 53
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RARA retinoic acid receptor, alpha
REC8 REC8 meiotic recombination protein
RELN reelin
RNF122 ring finger protein 122
RNF17 ring finger protein 17
RORC RAR-related orphan receptor C
RPS11 ribosomal protein S11
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SENP5 SUMO1/sentrin specific peptidase 5
SFTPC surfactant protein C
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMG5 SMG5 nonsense mediated mRNA decay factor
SOGA1 suppressor of glucose, autophagy associated 1
STK24 serine/threonine kinase 24
STX7 syntaxin 7
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNE1 spectrin repeat containing, nuclear envelope 1
TBKBP1 TBK1 binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDRKH tudor and KH domain containing
TFF2 trefoil factor 2
TM4SF5 transmembrane 4 L six family member 5
TMEM259 transmembrane protein 259
TMEM59L transmembrane protein 59-like
TMPRSS4 transmembrane protease, serine 4
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TSC22D2 TSC22 domain family, member 2
TTC22 tetratricopeptide repeat domain 22
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VWA5A von Willebrand factor A domain containing 5A
WAS Wiskott-Aldrich syndrome
WNT16 wingless-type MMTV integration site family, member 16
ZBTB22 zinc finger and BTB domain containing 22
ZNF235 zinc finger protein 235
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACTA1 actin, alpha 1, skeletal muscle
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APLP1 amyloid beta (A4) precursor-like protein 1
ART1 ADP-ribosyltransferase 1
AVPR1B arginine vasopressin receptor 1B
BCL2A1 BCL2-related protein A1
BCO1 beta-carotene oxygenase 1
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CABP5 calcium binding protein 5
CACNG3 calcium channel, voltage-dependent, gamma subunit 3
CBX8 chromobox homolog 8
CCDC71 coiled-coil domain containing 71
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CEND1 cell cycle exit and neuronal differentiation 1
CETN1 centrin, EF-hand protein, 1
CLCA1 chloride channel accessory 1
CORT cortistatin
CPLX2 complexin 2
CRLF1 cytokine receptor-like factor 1
DGAT1 diacylglycerol O-acyltransferase 1
DTX2 deltex 2, E3 ubiquitin ligase
DUOX2 dual oxidase 2
EMP3 epithelial membrane protein 3
ERCC6 excision repair cross-complementation group 6
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FKBP1B FK506 binding protein 1B, 12.6 kDa
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GIPR gastric inhibitory polypeptide receptor
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR21 G protein-coupled receptor 21
GRAMD1C GRAM domain containing 1C
HAO1 hydroxyacid oxidase (glycolate oxidase) 1
HOXB2 homeobox B2
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IGKV3-20 immunoglobulin kappa variable 3-20
INHA inhibin, alpha
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNIP2 Kv channel interacting protein 2
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KCTD17 potassium channel tetramerization domain containing 17
KIAA0125 KIAA0125
KLHL28 kelch-like family member 28
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LECT2 leukocyte cell-derived chemotaxin 2
LENEP lens epithelial protein
MALL mal, T-cell differentiation protein-like
MAPK10 mitogen-activated protein kinase 10
NANOG Nanog homeobox
NKX3-2 NK3 homeobox 2
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NYNRIN NYN domain and retroviral integrase containing
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PALM paralemmin
PARP3 poly (ADP-ribose) polymerase family, member 3
PCDH12 protocadherin 12
PLAC4 placenta-specific 4
PLTP phospholipid transfer protein
POU5F1B POU class 5 homeobox 1B
RAB40A RAB40A, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
S1PR2 sphingosine-1-phosphate receptor 2
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SIPA1 signal-induced proliferation-associated 1
SLAMF7 SLAM family member 7
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC22A14 solute carrier family 22, member 14
SLFN12 schlafen family member 12
SOCS7 suppressor of cytokine signaling 7
SPINK5 serine peptidase inhibitor, Kazal type 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STON1 stonin 1
SULT4A1 sulfotransferase family 4A, member 1
TBC1D2 TBC1 domain family, member 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TDRD12 tudor domain containing 12
TEX14 testis expressed 14
TMPRSS5 transmembrane protease, serine 5
TRDMT1 tRNA aspartic acid methyltransferase 1
TTLL7 tubulin tyrosine ligase-like family member 7
UPP1 uridine phosphorylase 1
USB1 U6 snRNA biogenesis 1
VIPR1 vasoactive intestinal peptide receptor 1
WDR62 WD repeat domain 62
WFDC2 WAP four-disulfide core domain 2
XCR1 chemokine (C motif) receptor 1
YPEL1 yippee-like 1 (Drosophila)
ZFHX4 zinc finger homeobox 4
ZNF329 zinc finger protein 329
ZNF37BP zinc finger protein 37B, pseudogene
ZNF423 zinc finger protein 423
ZNF76 zinc finger protein 76