estradiol-5910 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the estradiol-5910 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
AGMAT agmatine ureohydrolase (agmatinase)
AKAP5 A kinase (PRKA) anchor protein 5
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
AMBRA1 autophagy/beclin-1 regulator 1
ASTN2 astrotactin 2
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP9A ATPase, class II, type 9A
BBC3 BCL2 binding component 3
BMP2 bone morphogenetic protein 2
C10ORF10 chromosome 10 open reading frame 10
C11ORF80 chromosome 11 open reading frame 80
C1ORF116 chromosome 1 open reading frame 116
C1QL1 complement component 1, q subcomponent-like 1
C5ORF42 chromosome 5 open reading frame 42
C9ORF9 chromosome 9 open reading frame 9
CALD1 caldesmon 1
CEP152 centrosomal protein 152kDa
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLSTN3 calsyntenin 3
CNOT4 CCR4-NOT transcription complex, subunit 4
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DOCK6 dedicator of cytokinesis 6
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EEA1 early endosome antigen 1
EGFR epidermal growth factor receptor
ELOVL5 ELOVL fatty acid elongase 5
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
FOXG1 forkhead box G1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GFER growth factor, augmenter of liver regeneration
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR161 G protein-coupled receptor 161
GPR25 G protein-coupled receptor 25
ICOSLG inducible T-cell co-stimulator ligand
IGHMBP2 immunoglobulin mu binding protein 2
INADL InaD-like (Drosophila)
IRF4 interferon regulatory factor 4
LRRC75B leucine rich repeat containing 75B
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MFAP3L microfibrillar-associated protein 3-like
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MMP25 matrix metallopeptidase 25
MST1 macrophage stimulating 1
MUC3A mucin 3A, cell surface associated
NCAPH2 non-SMC condensin II complex, subunit H2
NDNF neuron-derived neurotrophic factor
NF2 neurofibromin 2 (merlin)
NKX3-2 NK3 homeobox 2
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPTX1 neuronal pentraxin I
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRF1 nuclear respiratory factor 1
OGFR opioid growth factor receptor
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PCDH1 protocadherin 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PGM5 phosphoglucomutase 5
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
RAB27B RAB27B, member RAS oncogene family
RAB2A RAB2A, member RAS oncogene family
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RGS17 regulator of G-protein signaling 17
RHBDD3 rhomboid domain containing 3
RIBC2 RIB43A domain with coiled-coils 2
RNF122 ring finger protein 122
SAYSD1 SAYSVFN motif domain containing 1
SCARB2 scavenger receptor class B, member 2
SMR3A submaxillary gland androgen regulated protein 3A
SORBS1 sorbin and SH3 domain containing 1
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TM2D1 TM2 domain containing 1
TOX4 TOX high mobility group box family member 4
TRAIP TRAF interacting protein
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIM22 tripartite motif containing 22
TTLL1 tubulin tyrosine ligase-like family member 1
TTLL3 tubulin tyrosine ligase-like family member 3
UBR4 ubiquitin protein ligase E3 component n-recognin 4
ZBTB7A zinc finger and BTB domain containing 7A
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF268 zinc finger protein 268
ZNF41 zinc finger protein 41
ZNF675 zinc finger protein 675
ZNF74 zinc finger protein 74
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AADAC arylacetamide deacetylase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACBD4 acyl-CoA binding domain containing 4
ADAM15 ADAM metallopeptidase domain 15
ADTRP androgen-dependent TFPI-regulating protein
AEN apoptosis enhancing nuclease
AIM2 absent in melanoma 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
APOL6 apolipoprotein L, 6
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASPHD1 aspartate beta-hydroxylase domain containing 1
AURKC aurora kinase C
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTF3P11 basic transcription factor 3 pseudogene 11
C17ORF53 chromosome 17 open reading frame 53
CCDC132 coiled-coil domain containing 132
CCDC181 coiled-coil domain containing 181
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD80 CD80 molecule
CEL carboxyl ester lipase
CHRDL1 chordin-like 1
CLIC3 chloride intracellular channel 3
CLTCL1 clathrin, heavy chain-like 1
CNGB3 cyclic nucleotide gated channel beta 3
COBL cordon-bleu WH2 repeat protein
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DPY19L1P1 DPY19L1 pseudogene 1
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ELP3 elongator acetyltransferase complex subunit 3
EN2 engrailed homeobox 2
ETAA1 Ewing tumor-associated antigen 1
FAM110B family with sequence similarity 110, member B
FAM131B family with sequence similarity 131, member B
FAM46C family with sequence similarity 46, member C
FAM63A family with sequence similarity 63, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FKBP5 FK506 binding protein 5
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FZD10 frizzled class receptor 10
GAL3ST4 galactose-3-O-sulfotransferase 4
GJA8 gap junction protein, alpha 8, 50kDa
GK2 glycerol kinase 2
GPR157 G protein-coupled receptor 157
GPR85 G protein-coupled receptor 85
GRTP1 growth hormone regulated TBC protein 1
HIST1H2BN histone cluster 1, H2bn
HIST1H3G histone cluster 1, H3g
HIST1H4E histone cluster 1, H4e
ICAM5 intercellular adhesion molecule 5, telencephalin
IFT81 intraflagellar transport 81
KIAA1456 KIAA1456
KRT31 keratin 31, type I
LIPG lipase, endothelial
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
MANEA mannosidase, endo-alpha
MAP3K7CL MAP3K7 C-terminal like
MRAS muscle RAS oncogene homolog
MRPL44 mitochondrial ribosomal protein L44
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NCALD neurocalcin delta
NIPAL2 NIPA-like domain containing 2
NSUN6 NOP2/Sun domain family, member 6
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OR3A3 olfactory receptor, family 3, subfamily A, member 3
OVGP1 oviductal glycoprotein 1, 120kDa
PAIP2B poly(A) binding protein interacting protein 2B
PCDHGB5 protocadherin gamma subfamily B, 5
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDZK1 PDZ domain containing 1
PIPOX pipecolic acid oxidase
PRR4 proline rich 4 (lacrimal)
PRSS22 protease, serine, 22
PXMP4 peroxisomal membrane protein 4, 24kDa
SCD5 stearoyl-CoA desaturase 5
SCN10A sodium channel, voltage gated, type X alpha subunit
SCRT1 scratch family zinc finger 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLMO1 slowmo homolog 1 (Drosophila)
STIM1 stromal interaction molecule 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYCP2 synaptonemal complex protein 2
TFDP3 transcription factor Dp family, member 3
TFEB transcription factor EB
TIAM2 T-cell lymphoma invasion and metastasis 2
TMEM74B transmembrane protein 74B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TONSL tonsoku-like, DNA repair protein
TSNAXIP1 translin-associated factor X interacting protein 1
TTC26 tetratricopeptide repeat domain 26
TTC30A tetratricopeptide repeat domain 30A
VN1R1 vomeronasal 1 receptor 1
ZNF362 zinc finger protein 362
ZNF37BP zinc finger protein 37B, pseudogene
ZNF573 zinc finger protein 573