estradiol-5955 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the estradiol-5955 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARL4C ADP-ribosylation factor-like 4C
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATN1 atrophin 1
BAIAP3 BAI1-associated protein 3
BEGAIN brain-enriched guanylate kinase-associated
BIRC7 baculoviral IAP repeat containing 7
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD22 CD22 molecule
CD8A CD8a molecule
CDC25A cell division cycle 25A
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFLAR CASP8 and FADD-like apoptosis regulator
COL21A1 collagen, type XXI, alpha 1
COL5A1 collagen, type V, alpha 1
COL6A3 collagen, type VI, alpha 3
CXADR coxsackie virus and adenovirus receptor
DIO2 deiodinase, iodothyronine, type II
DOCK6 dedicator of cytokinesis 6
DTNA dystrobrevin, alpha
DUSP6 dual specificity phosphatase 6
DVL2 dishevelled segment polarity protein 2
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
FABP7 fatty acid binding protein 7, brain
FMOD fibromodulin
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPM6B glycoprotein M6B
GPR3 G protein-coupled receptor 3
HHAT hedgehog acyltransferase
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRF5 interferon regulatory factor 5
ITGA6 integrin, alpha 6
KLF7 Kruppel-like factor 7 (ubiquitous)
LAMP1 lysosomal-associated membrane protein 1
LAT2 linker for activation of T cells family, member 2
LEFTY2 left-right determination factor 2
LIME1 Lck interacting transmembrane adaptor 1
LINC00312 long intergenic non-protein coding RNA 312
LMAN1 lectin, mannose-binding, 1
LOXL3 lysyl oxidase-like 3
MAN1A2 mannosidase, alpha, class 1A, member 2
MAP1B microtubule-associated protein 1B
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MAX MYC associated factor X
MED18 mediator complex subunit 18
MLX MLX, MAX dimerization protein
MORN1 MORN repeat containing 1
MVB12B multivesicular body subunit 12B
NCAPH2 non-SMC condensin II complex, subunit H2
NF1 neurofibromin 1
NOV nephroblastoma overexpressed
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAPPA2 pappalysin 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCDHB13 protocadherin beta 13
PCNX pecanex homolog (Drosophila)
PDE12 phosphodiesterase 12
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POLL polymerase (DNA directed), lambda
POU2F2 POU class 2 homeobox 2
PTCRA pre T-cell antigen receptor alpha
QKI QKI, KH domain containing, RNA binding
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RNF6 ring finger protein (C3H2C3 type) 6
SCARB1 scavenger receptor class B, member 1
SECTM1 secreted and transmembrane 1
SH2B1 SH2B adaptor protein 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC12A8 solute carrier family 12, member 8
SLC25A40 solute carrier family 25, member 40
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPAG8 sperm associated antigen 8
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STK3 serine/threonine kinase 3
STK38L serine/threonine kinase 38 like
STRN striatin, calmodulin binding protein
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBC1D5 TBC1 domain family, member 5
TFG TRK-fused gene
TMEM242 transmembrane protein 242
TRIM3 tripartite motif containing 3
TTLL1 tubulin tyrosine ligase-like family member 1
TUBGCP2 tubulin, gamma complex associated protein 2
ULBP2 UL16 binding protein 2
WNK1 WNK lysine deficient protein kinase 1
ZCCHC14 zinc finger, CCHC domain containing 14
ZDHHC14 zinc finger, DHHC-type containing 14
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF227 zinc finger protein 227
ZNF589 zinc finger protein 589
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADAP2 ArfGAP with dual PH domains 2
AHNAK2 AHNAK nucleoprotein 2
ALS2CL ALS2 C-terminal like
AMH anti-Mullerian hormone
ANXA1 annexin A1
ARMC4 armadillo repeat containing 4
ASIC2 acid sensing (proton gated) ion channel 2
ATP10D ATPase, class V, type 10D
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
C1ORF159 chromosome 1 open reading frame 159
CARD9 caspase recruitment domain family, member 9
CCL22 chemokine (C-C motif) ligand 22
CD53 CD53 molecule
CFAP45 cilia and flagella associated protein 45
COLEC11 collectin sub-family member 11
DAPK2 death-associated protein kinase 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DMTN dematin actin binding protein
DNAH17 dynein, axonemal, heavy chain 17
DNALI1 dynein, axonemal, light intermediate chain 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPY19L1P1 DPY19L1 pseudogene 1
DTX2 deltex 2, E3 ubiquitin ligase
ECEL1 endothelin converting enzyme-like 1
EPX eosinophil peroxidase
F2R coagulation factor II (thrombin) receptor
FAM131A family with sequence similarity 131, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
GPC3 glypican 3
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRM2 glutamate receptor, metabotropic 2
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1T histone cluster 1, H1t
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
IL12RB1 interleukin 12 receptor, beta 1
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCTD17 potassium channel tetramerization domain containing 17
KIAA0319L KIAA0319-like
KIAA0754 KIAA0754
KIAA1107 KIAA1107
KLRF1 killer cell lectin-like receptor subfamily F, member 1
LHX3 LIM homeobox 3
LIN7A lin-7 homolog A (C. elegans)
LMTK1 lemur tail kinase 1
LOC157562 uncharacterized LOC157562
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LPAR3 lysophosphatidic acid receptor 3
MAP1S microtubule-associated protein 1S
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MEFV Mediterranean fever
MMRN2 multimerin 2
MX1 MX dynamin-like GTPase 1
NFE2L3 nuclear factor, erythroid 2-like 3
NKX3-2 NK3 homeobox 2
NNAT neuronatin
NOTCH4 notch 4
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NT5M 5',3'-nucleotidase, mitochondrial
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PALM paralemmin
PGP phosphoglycolate phosphatase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POMT2 protein-O-mannosyltransferase 2
POU5F1B POU class 5 homeobox 1B
PYCRL pyrroline-5-carboxylate reductase-like
RGS2 regulator of G-protein signaling 2
RNF126P1 ring finger protein 126 pseudogene 1
RORC RAR-related orphan receptor C
RPL13P5 ribosomal protein L13 pseudogene 5
S100A9 S100 calcium binding protein A9
SCAMP3 secretory carrier membrane protein 3
SDC3 syndecan 3
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SSTR5 somatostatin receptor 5
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMPRSS6 transmembrane protease, serine 6
TRABD TraB domain containing
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRAPPC11 trafficking protein particle complex 11
VAX2 ventral anterior homeobox 2
VEZT vezatin, adherens junctions transmembrane protein
XYLT1 xylosyltransferase I
ZNF286A zinc finger protein 286A
ZNF510 zinc finger protein 510
ZNF747 zinc finger protein 747