estradiol-988 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the estradiol-988 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADGRL1 adhesion G protein-coupled receptor L1
AKAP13 A kinase (PRKA) anchor protein 13
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALS2CL ALS2 C-terminal like
ANKFY1 ankyrin repeat and FYVE domain containing 1
AR androgen receptor
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP11A ATPase, class VI, type 11A
ATRNL1 attractin-like 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCL2L11 BCL2-like 11 (apoptosis facilitator)
C1QTNF3 C1q and tumor necrosis factor related protein 3
CABIN1 calcineurin binding protein 1
CBX7 chromobox homolog 7
CCDC132 coiled-coil domain containing 132
CENPT centromere protein T
CNGB3 cyclic nucleotide gated channel beta 3
CXORF21 chromosome X open reading frame 21
DIEXF digestive organ expansion factor homolog (zebrafish)
DSC2 desmocollin 2
EGR3 early growth response 3
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EPB41L1 erythrocyte membrane protein band 4.1-like 1
ERCC2 excision repair cross-complementation group 2
EXOG endo/exonuclease (5'-3'), endonuclease G-like
F3 coagulation factor III (thromboplastin, tissue factor)
FAM198B family with sequence similarity 198, member B
FOSL2 FOS-like antigen 2
GALC galactosylceramidase
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GMIP GEM interacting protein
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BC histone cluster 1, H2bc
HPS1 Hermansky-Pudlak syndrome 1
HSF1 heat shock transcription factor 1
ICA1 islet cell autoantigen 1, 69kDa
IDI2-AS1 IDI2 antisense RNA 1
IFT27 intraflagellar transport 27
IFT54 intraflagellar transport 54
IL6ST interleukin 6 signal transducer
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KLHL29 kelch-like family member 29
KREMEN2 kringle containing transmembrane protein 2
LINC00341 long intergenic non-protein coding RNA 341
LOC390998 ribosomal protein L10 pseudogene
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LZTR1 leucine-zipper-like transcription regulator 1
MAPKAPK5-AS1 MAPKAPK5 antisense RNA 1
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
OTUD4 OTU deubiquitinase 4
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PHF20 PHD finger protein 20
PITX2 paired-like homeodomain 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLXNA1 plexin A1
POLL polymerase (DNA directed), lambda
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKD3 protein kinase D3
PSG6 pregnancy specific beta-1-glycoprotein 6
PSG9 pregnancy specific beta-1-glycoprotein 9
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RAB35 RAB35, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RGS10 regulator of G-protein signaling 10
RLN1 relaxin 1
RNF126P1 ring finger protein 126 pseudogene 1
RPGRIP1L RPGRIP1-like
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
SCAPER S-phase cyclin A-associated protein in the ER
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMG7 SMG7 nonsense mediated mRNA decay factor
SOCS6 suppressor of cytokine signaling 6
SORT1 sortilin 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STK38L serine/threonine kinase 38 like
SYBU syntabulin (syntaxin-interacting)
SYK spleen tyrosine kinase
TENM4 teneurin transmembrane protein 4
TEP1 telomerase-associated protein 1
TMSB15A thymosin beta 15a
TRIM3 tripartite motif containing 3
TTBK2 tau tubulin kinase 2
USB1 U6 snRNA biogenesis 1
UTRN utrophin
WDR59 WD repeat domain 59
XK X-linked Kx blood group
ZBTB1 zinc finger and BTB domain containing 1
ZFP37 ZFP37 zinc finger protein
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF329 zinc finger protein 329
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADGRE5 adhesion G protein-coupled receptor E5
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
C11ORF68 chromosome 11 open reading frame 68
CAPN15 calpain 15
CASZ1 castor zinc finger 1
CCDC130 coiled-coil domain containing 130
CCDC25 coiled-coil domain containing 25
CCDC68 coiled-coil domain containing 68
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CGREF1 cell growth regulator with EF-hand domain 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CIDEC cell death-inducing DFFA-like effector c
CLDN4 claudin 4
CLSPN claspin
CORO2A coronin, actin binding protein, 2A
CRY2 cryptochrome circadian clock 2
CSTA cystatin A (stefin A)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSCAM Down syndrome cell adhesion molecule
DUSP8 dual specificity phosphatase 8
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EDC4 enhancer of mRNA decapping 4
EFCAB2 EF-hand calcium binding domain 2
EPHA4 EPH receptor A4
FAM188A family with sequence similarity 188, member A
FIP1L1 factor interacting with PAPOLA and CPSF1
FMO4 flavin containing monooxygenase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLCE glucuronic acid epimerase
GPATCH3 G patch domain containing 3
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HS1BP3 HCLS1 binding protein 3
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IPO13 importin 13
IRF9 interferon regulatory factor 9
KAT2A K(lysine) acetyltransferase 2A
KDM7A lysine (K)-specific demethylase 7A
KIAA0894 KIAA0894 protein
LIG4 ligase IV, DNA, ATP-dependent
LOC100272216 uncharacterized LOC100272216
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN2B1 mannosidase, alpha, class 2B, member 1
MDM4 MDM4, p53 regulator
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MTA2 metastasis associated 1 family, member 2
NAIP NLR family, apoptosis inhibitory protein
NLK nemo-like kinase
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAQR6 progestin and adipoQ receptor family member VI
PGP phosphoglycolate phosphatase
PRAF2 PRA1 domain family, member 2
PROCR protein C receptor, endothelial
RAD54L RAD54-like (S. cerevisiae)
RBL1 retinoblastoma-like 1
REEP4 receptor accessory protein 4
RPAP2 RNA polymerase II associated protein 2
RPS17P5 ribosomal protein S17 pseudogene 5
SCD5 stearoyl-CoA desaturase 5
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SETD1A SET domain containing 1A
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC38A10 solute carrier family 38, member 10
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMA4 glucuronidase, beta pseudogene
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPIDR scaffolding protein involved in DNA repair
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THAP7 THAP domain containing 7
TMEM115 transmembrane protein 115
TMEM62 transmembrane protein 62
TRIP10 thyroid hormone receptor interactor 10
UNC119 unc-119 homolog (C. elegans)
UNKL unkempt family zinc finger-like
WDR4 WD repeat domain 4
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB22 zinc finger and BTB domain containing 22
ZNF721 zinc finger protein 721
ZNF787 zinc finger protein 787
ZNRD1-AS1 ZNRD1 antisense RNA 1