estradiol Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17. (Chemical Entities of Biological Interest Ontology, CHEBI_23965)
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Genes

155 genes co-occuring with the biological term estradiol in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADIPOQ adiponectin, C1Q and collagen domain containing
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMH anti-Mullerian hormone
APP amyloid beta (A4) precursor protein
AR androgen receptor
AREG amphiregulin
ATF3 activating transcription factor 3
AVP arginine vasopressin
BDNF brain-derived neurotrophic factor
BRCA1 breast cancer 1, early onset
BTG2 BTG family, member 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3 complement component 3
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CALR calreticulin
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CDH5 cadherin 5, type 2 (vascular endothelium)
CGB chorionic gonadotropin, beta polypeptide
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
COMT catechol-O-methyltransferase
CPB2 carboxypeptidase B2 (plasma)
CRHR2 corticotropin releasing hormone receptor 2
CRP C-reactive protein, pentraxin-related
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
DDAH1 dimethylarginine dimethylaminohydrolase 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FOS FBJ murine osteosarcoma viral oncogene homolog
FSHB follicle stimulating hormone, beta polypeptide
GH1 growth hormone 1
GHR growth hormone receptor
GHRL ghrelin/obestatin prepropeptide
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPER1 G protein-coupled estrogen receptor 1
GSTM1 glutathione S-transferase mu 1
HAS1 hyaluronan synthase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-G major histocompatibility complex, class I, G
HOTAIR HOX transcript antisense RNA
HPSE heparanase
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
IL1B interleukin 1, beta
IL2RA interleukin 2 receptor, alpha
IL6 interleukin 6
INHA inhibin, alpha
INHBB inhibin, beta B
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KIAA1524 KIAA1524
KMT2A lysine (K)-specific methyltransferase 2A
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LEP leptin
LEPQTL1 Leptin, serum levels of
LGALS3 lectin, galactoside-binding, soluble, 3
LHB luteinizing hormone beta polypeptide
LIPE lipase, hormone-sensitive
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAPKAP1 mitogen-activated protein kinase associated protein 1
MBD4 methyl-CpG binding domain protein 4
MDK midkine (neurite growth-promoting factor 2)
MICA MHC class I polypeptide-related sequence A
MIR135B microRNA 135b
MIR148A microRNA 148a
MIR155 microRNA 155
MLH1 mutL homolog 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MSH2 mutS homolog 2
MSI1 musashi RNA-binding protein 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCOA1 nuclear receptor coactivator 1
NCOA3 nuclear receptor coactivator 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NR5A1 nuclear receptor subfamily 5, group A, member 1
OXTR oxytocin receptor
PDIA2 protein disulfide isomerase family A, member 2
PELP1 proline, glutamate and leucine rich protein 1
PGR progesterone receptor
PHB2 prohibitin 2
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PRDM2 PR domain containing 2, with ZNF domain
PRKCA protein kinase C, alpha
PRL prolactin
PRLR prolactin receptor
PTEN phosphatase and tensin homolog
PTX3 pentraxin 3, long
RACGAP1 Rac GTPase activating protein 1
RERG RAS-like, estrogen-regulated, growth inhibitor
RETN resistin
RHOU ras homolog family member U
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SDC2 syndecan 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHBG sex hormone-binding globulin
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SOCS2 suppressor of cytokine signaling 2
SP1 Sp1 transcription factor
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TCL1A T-cell leukemia/lymphoma 1A
TERT telomerase reverse transcriptase
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TNC tenascin C
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TRIM25 tripartite motif containing 25
UCN2 urocortin 2
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A