estropipate-6068 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the estropipate-6068 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGFG2 ArfGAP with FG repeats 2
ANGPT4 angiopoietin 4
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARR3 arrestin 3, retinal (X-arrestin)
BAAT bile acid CoA:amino acid N-acyltransferase
BAIAP3 BAI1-associated protein 3
BMP8B bone morphogenetic protein 8b
C4BPA complement component 4 binding protein, alpha
CARD10 caspase recruitment domain family, member 10
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CEND1 cell cycle exit and neuronal differentiation 1
COL5A2 collagen, type V, alpha 2
CRYGD crystallin, gamma D
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DGCR8 DGCR8 microprocessor complex subunit
DGKG diacylglycerol kinase, gamma 90kDa
DGKQ diacylglycerol kinase, theta 110kDa
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DMTN dematin actin binding protein
DOCK5 dedicator of cytokinesis 5
EGR3 early growth response 3
ELF5 E74-like factor 5 (ets domain transcription factor)
EXOC6B exocyst complex component 6B
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GBP2 guanylate binding protein 2, interferon-inducible
GK3P glycerol kinase 3 pseudogene
GPR3 G protein-coupled receptor 3
HIST1H4A histone cluster 1, H4a
HLA-DOA major histocompatibility complex, class II, DO alpha
HPX hemopexin
HR hair growth associated
HRG histidine-rich glycoprotein
IFI6 interferon, alpha-inducible protein 6
IGHA1 immunoglobulin heavy constant alpha 1
IL1B interleukin 1, beta
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KDM5D lysine (K)-specific demethylase 5D
KIAA1462 KIAA1462
LEFTY2 left-right determination factor 2
LIF leukemia inhibitory factor
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LPL lipoprotein lipase
LTB4R leukotriene B4 receptor
MAOB monoamine oxidase B
MAP2K7 mitogen-activated protein kinase kinase 7
METTL7A methyltransferase like 7A
MFSD6 major facilitator superfamily domain containing 6
MLXIP MLX interacting protein
MRPS18C mitochondrial ribosomal protein S18C
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NPPA natriuretic peptide A
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR5A2 nuclear receptor subfamily 5, group A, member 2
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OSGIN2 oxidative stress induced growth inhibitor family member 2
OTOR otoraplin
OVGP1 oviductal glycoprotein 1, 120kDa
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PCDHGA3 protocadherin gamma subfamily A, 3
PGR progesterone receptor
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POU5F1B POU class 5 homeobox 1B
PPP1R37 protein phosphatase 1, regulatory subunit 37
PRB1 proline-rich protein BstNI subfamily 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PVT1 Pvt1 oncogene (non-protein coding)
RAB3B RAB3B, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RORC RAR-related orphan receptor C
SCNN1B sodium channel, non voltage gated 1 beta subunit
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SFRP4 secreted frizzled-related protein 4
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SHOX2 short stature homeobox 2
SIPA1 signal-induced proliferation-associated 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SOGA1 suppressor of glucose, autophagy associated 1
SPRY4 sprouty homolog 4 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SULT4A1 sulfotransferase family 4A, member 1
TGM2 transglutaminase 2
THEMIS2 thymocyte selection associated family member 2
TLDC1 TBC/LysM-associated domain containing 1
TLX3 T-cell leukemia homeobox 3
TMPRSS4 transmembrane protease, serine 4
TRIO trio Rho guanine nucleotide exchange factor
TSC22D2 TSC22 domain family, member 2
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
USP53 ubiquitin specific peptidase 53
ZNF197 zinc finger protein 197

decreased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ADAP2 ArfGAP with dual PH domains 2
AGMAT agmatine ureohydrolase (agmatinase)
APOD apolipoprotein D
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
C14ORF93 chromosome 14 open reading frame 93
C2ORF27A chromosome 2 open reading frame 27A
C5AR2 complement component 5a receptor 2
CASD1 CAS1 domain containing 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC186 coiled-coil domain containing 186
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CENPO centromere protein O
CFAP45 cilia and flagella associated protein 45
CHKB choline kinase beta
CHRM3 cholinergic receptor, muscarinic 3
CIDEC cell death-inducing DFFA-like effector c
CLDN1 claudin 1
COPZ2 coatomer protein complex, subunit zeta 2
CRELD1 cysteine-rich with EGF-like domains 1
CRLF1 cytokine receptor-like factor 1
CXADR coxsackie virus and adenovirus receptor
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAH17 dynein, axonemal, heavy chain 17
ECHDC2 enoyl CoA hydratase domain containing 2
EGFL7 EGF-like-domain, multiple 7
ERCC6 excision repair cross-complementation group 6
FAAH fatty acid amide hydrolase
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GEMIN8 gem (nuclear organelle) associated protein 8
GPATCH2L G patch domain containing 2-like
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2AK histone cluster 1, H2ak
HIST1H4D histone cluster 1, H4d
HIST1H4E histone cluster 1, H4e
HLA-J major histocompatibility complex, class I, J (pseudogene)
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC10 homeobox C10
HOXC5 homeobox C5
IFNA14 interferon, alpha 14
IL12RB1 interleukin 12 receptor, beta 1
IL22 interleukin 22
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIF13A kinesin family member 13A
KLF7 Kruppel-like factor 7 (ubiquitous)
KREMEN2 kringle containing transmembrane protein 2
KRT24 keratin 24, type I
LAX1 lymphocyte transmembrane adaptor 1
LOC390998 ribosomal protein L10 pseudogene
LRRC6 leucine rich repeat containing 6
LRRC61 leucine rich repeat containing 61
LZTR1 leucine-zipper-like transcription regulator 1
MAST3 microtubule associated serine/threonine kinase 3
MMP3 matrix metallopeptidase 3
NLRX1 NLR family member X1
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2A olfactomedin-like 2A
ONECUT2 one cut homeobox 2
PCDH12 protocadherin 12
PDE8B phosphodiesterase 8B
PLAU plasminogen activator, urokinase
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PQLC2 PQ loop repeat containing 2
PSD4 pleckstrin and Sec7 domain containing 4
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB40AL RAB40A, member RAS oncogene family-like
RNF126P1 ring finger protein 126 pseudogene 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SHARPIN SHANK-associated RH domain interactor
SLC12A8 solute carrier family 12, member 8
SLC17A2 solute carrier family 17, member 2
SLC22A14 solute carrier family 22, member 14
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAOK1 TAO kinase 1
TMEM121 transmembrane protein 121
TMEM209 transmembrane protein 209
TOM1 target of myb1 (chicken)
TRIM25 tripartite motif containing 25
UBXN6 UBX domain protein 6
VLDLR very low density lipoprotein receptor
WNT10B wingless-type MMTV integration site family, member 10B
XDH xanthine dehydrogenase
ZC3H3 zinc finger CCCH-type containing 3
ZDHHC14 zinc finger, DHHC-type containing 14
ZMAT5 zinc finger, matrin-type 5
ZNF205 zinc finger protein 205
ZNF606 zinc finger protein 606
ZNF74 zinc finger protein 74