ethambutol-4120 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ethambutol-4120 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADAM22 ADAM metallopeptidase domain 22
AHNAK2 AHNAK nucleoprotein 2
AJAP1 adherens junctions associated protein 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C4 aldo-keto reductase family 1, member C4
ANGPTL2 angiopoietin-like 2
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARRB1 arrestin, beta 1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP10B ATPase, class V, type 10B
BMP8B bone morphogenetic protein 8b
CA1 carbonic anhydrase I
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CASS4 Cas scaffolding protein family member 4
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP164 centrosomal protein 164kDa
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CNTNAP2 contactin associated protein-like 2
CPQ carboxypeptidase Q
CTAG2 cancer/testis antigen 2
DAPK2 death-associated protein kinase 2
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DOPEY2 dopey family member 2
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
ERAP1 endoplasmic reticulum aminopeptidase 1
FAM66D family with sequence similarity 66, member D
FBXO2 F-box protein 2
FGFBP1 fibroblast growth factor binding protein 1
FKBP8 FK506 binding protein 8, 38kDa
FRMD4A FERM domain containing 4A
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GJA9 gap junction protein, alpha 9, 59kDa
GK3P glycerol kinase 3 pseudogene
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR143 G protein-coupled receptor 143
GPR15 G protein-coupled receptor 15
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HIST1H4E histone cluster 1, H4e
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPM heterogeneous nuclear ribonucleoprotein M
HOXA11 homeobox A11
HSPG2 heparan sulfate proteoglycan 2
IPW imprinted in Prader-Willi syndrome (non-protein coding)
IRS4 insulin receptor substrate 4
KCTD17 potassium channel tetramerization domain containing 17
KIAA1107 KIAA1107
KIF1C kinesin family member 1C
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRP12 low density lipoprotein receptor-related protein 12
MAL mal, T-cell differentiation protein
MED25 mediator complex subunit 25
MEFV Mediterranean fever
MOBP myelin-associated oligodendrocyte basic protein
MYLK myosin light chain kinase
NCKIPSD NCK interacting protein with SH3 domain
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NF2 neurofibromin 2 (merlin)
NOL10 nucleolar protein 10
NPY2R neuropeptide Y receptor Y2
NUDCD3 NudC domain containing 3
NUP54 nucleoporin 54kDa
OXCT2 3-oxoacid CoA transferase 2
PAQR5 progestin and adipoQ receptor family member V
PCNX pecanex homolog (Drosophila)
PCSK6 proprotein convertase subtilisin/kexin type 6
PPARA peroxisome proliferator-activated receptor alpha
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PQLC2 PQ loop repeat containing 2
PRPH2 peripherin 2 (retinal degeneration, slow)
RGS12 regulator of G-protein signaling 12
SFTPB surfactant protein B
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC6A16 solute carrier family 6, member 16
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SPAG8 sperm associated antigen 8
SSPN sarcospan
SSTR5 somatostatin receptor 5
TBC1D22A TBC1 domain family, member 22A
TBRG4 transforming growth factor beta regulator 4
TCP10L t-complex 10-like
TEX15 testis expressed 15
THRB thyroid hormone receptor, beta
TREX1 three prime repair exonuclease 1
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TUBA4B tubulin, alpha 4b
UHRF1BP1L UHRF1 binding protein 1-like
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTL8 actin-like 8
ADGRE5 adhesion G protein-coupled receptor E5
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AKAP12 A kinase (PRKA) anchor protein 12
AMT aminomethyltransferase
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAHCC1 BAH domain and coiled-coil containing 1
BMP15 bone morphogenetic protein 15
C11ORF80 chromosome 11 open reading frame 80
C19ORF66 chromosome 19 open reading frame 66
C19ORF73 chromosome 19 open reading frame 73
C1ORF21 chromosome 1 open reading frame 21
CDKN2AIP CDKN2A interacting protein
CEL carboxyl ester lipase
CHML choroideremia-like (Rab escort protein 2)
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CIDEC cell death-inducing DFFA-like effector c
CLCF1 cardiotrophin-like cytokine factor 1
CLDND1 claudin domain containing 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CORO1A coronin, actin binding protein, 1A
CPEB3 cytoplasmic polyadenylation element binding protein 3
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTNNBIP1 catenin, beta interacting protein 1
CUL9 cullin 9
CUZD1 CUB and zona pellucida-like domains 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DYSF dysferlin
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
FAM184A family with sequence similarity 184, member A
FGF13 fibroblast growth factor 13
GLS2 glutaminase 2 (liver, mitochondrial)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GSTT1 glutathione S-transferase theta 1
GTF2I general transcription factor IIi
HIST2H2AA3 histone cluster 2, H2aa3
HP1BP3 heterochromatin protein 1, binding protein 3
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IDI2-AS1 IDI2 antisense RNA 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INO80D INO80 complex subunit D
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
INPP5J inositol polyphosphate-5-phosphatase J
IRAK4 interleukin-1 receptor-associated kinase 4
JMJD4 jumonji domain containing 4
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM5C lysine (K)-specific demethylase 5C
KIAA0125 KIAA0125
LAX1 lymphocyte transmembrane adaptor 1
LHX6 LIM homeobox 6
LPPR1 lipid phosphate phosphatase-related protein type 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MATK megakaryocyte-associated tyrosine kinase
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCOLN1 mucolipin 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NRSN2 neurensin 2
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
ODF2 outer dense fiber of sperm tails 2
PADI1 peptidyl arginine deiminase, type I
PDE8B phosphodiesterase 8B
POMT2 protein-O-mannosyltransferase 2
PRAMEF11 PRAME family member 11
PRR4 proline rich 4 (lacrimal)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
R3HCC1L R3H domain and coiled-coil containing 1-like
RNF122 ring finger protein 122
RPGR retinitis pigmentosa GTPase regulator
RPL10L ribosomal protein L10-like
S100A2 S100 calcium binding protein A2
SALL2 spalt-like transcription factor 2
SCRN3 secernin 3
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGK2 serum/glucocorticoid regulated kinase 2
SNTA1 syntrophin, alpha 1
SRD5A3 steroid 5 alpha-reductase 3
STK16 serine/threonine kinase 16
SYCP2 synaptonemal complex protein 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBC1D17 TBC1 domain family, member 17
TESC tescalcin
TMEM45A transmembrane protein 45A
TRIM36 tripartite motif containing 36
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
ULBP2 UL16 binding protein 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VIM vimentin
ZBTB44 zinc finger and BTB domain containing 44
ZNF211 zinc finger protein 211
ZNF862 zinc finger protein 862