ethisterone-3975 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ethisterone-3975 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADAM22 ADAM metallopeptidase domain 22
ADGB androglobin
ADGRA2 adhesion G protein-coupled receptor A2
ANKRD7 ankyrin repeat domain 7
ARTN artemin
BMP1 bone morphogenetic protein 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CD101 CD101 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK19 cyclin-dependent kinase 19
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
COL14A1 collagen, type XIV, alpha 1
CORO2B coronin, actin binding protein, 2B
CRHR2 corticotropin releasing hormone receptor 2
CST4 cystatin S
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DFNB31 deafness, autosomal recessive 31
DHRS12 dehydrogenase/reductase (SDR family) member 12
DIO2 deiodinase, iodothyronine, type II
DKFZP434L187 uncharacterized LOC26082
DRD2 dopamine receptor D2
EDDM3A epididymal protein 3A
ELL2 elongation factor, RNA polymerase II, 2
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EXPH5 exophilin 5
FGF22 fibroblast growth factor 22
FGF6 fibroblast growth factor 6
FOXE1 forkhead box E1
FRS3 fibroblast growth factor receptor substrate 3
GJD2 gap junction protein, delta 2, 36kDa
GRK5 G protein-coupled receptor kinase 5
HAMP hepcidin antimicrobial peptide
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IGHA1 immunoglobulin heavy constant alpha 1
KANK3 KN motif and ankyrin repeat domains 3
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA0509 uncharacterized LOC57242
KIAA1456 KIAA1456
LEF1 lymphoid enhancer-binding factor 1
LIME1 Lck interacting transmembrane adaptor 1
LOC100131510 uncharacterized LOC100131510
LPAR3 lysophosphatidic acid receptor 3
LTB4R leukotriene B4 receptor
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MEF2D myocyte enhancer factor 2D
MPO myeloperoxidase
MUC6 mucin 6, oligomeric mucus/gel-forming
NAG18 NAG18 mRNA
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NKX2-1 NK2 homeobox 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
NUDCD3 NudC domain containing 3
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
PALM paralemmin
PCDH11X protocadherin 11 X-linked
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDGFB platelet-derived growth factor beta polypeptide
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLG plasminogen
PLK3 polo-like kinase 3
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRELP proline/arginine-rich end leucine-rich repeat protein
RERE arginine-glutamic acid dipeptide (RE) repeats
RGCC regulator of cell cycle
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SAMD9 sterile alpha motif domain containing 9
SBNO2 strawberry notch homolog 2 (Drosophila)
SCN10A sodium channel, voltage gated, type X alpha subunit
SCNN1B sodium channel, non voltage gated 1 beta subunit
SERHL2 serine hydrolase-like 2
SIRPB1 signal-regulatory protein beta 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SSX1 synovial sarcoma, X breakpoint 1
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
TBKBP1 TBK1 binding protein 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TDRD12 tudor domain containing 12
TEF thyrotrophic embryonic factor
TIGD6 tigger transposable element derived 6
TJAP1 tight junction associated protein 1 (peripheral)
TRAPPC9 trafficking protein particle complex 9
TTLL5 tubulin tyrosine ligase-like family member 5
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VCX2 variable charge, X-linked 2
VPREB3 pre-B lymphocyte 3
WSCD1 WSC domain containing 1
ZNF223 zinc finger protein 223
ZNF235 zinc finger protein 235
ZNF391 zinc finger protein 391

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACPP acid phosphatase, prostate
ADM adrenomedullin
AFAP1 actin filament associated protein 1
ANXA2P1 annexin A2 pseudogene 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARMC4 armadillo repeat containing 4
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
BMP4 bone morphogenetic protein 4
BMP8B bone morphogenetic protein 8b
C10ORF95 chromosome 10 open reading frame 95
C1ORF159 chromosome 1 open reading frame 159
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2ORF27A chromosome 2 open reading frame 27A
C8ORF44 chromosome 8 open reading frame 44
CALML5 calmodulin-like 5
CARTPT CART prepropeptide
CCNK cyclin K
CDK6 cyclin-dependent kinase 6
CEND1 cell cycle exit and neuronal differentiation 1
CEP295 centrosomal protein 295kDa
CFAP44 cilia and flagella associated protein 44
CLEC4E C-type lectin domain family 4, member E
CRMP1 collapsin response mediator protein 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DGAT1 diacylglycerol O-acyltransferase 1
DLL3 delta-like 3 (Drosophila)
DOC2A double C2-like domains, alpha
DPY19L1P1 DPY19L1 pseudogene 1
DRD1 dopamine receptor D1
EDN1 endothelin 1
FAM110B family with sequence similarity 110, member B
FAM171A1 family with sequence similarity 171, member A1
FAM76A family with sequence similarity 76, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLJ22184
FMOD fibromodulin
GLB1L galactosidase, beta 1-like
GPRC5D G protein-coupled receptor, class C, group 5, member D
HIRA histone cell cycle regulator
HIST1H2AL histone cluster 1, H2al
HIST1H2BM histone cluster 1, H2bm
HOXC4 homeobox C4
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNA17 interferon, alpha 17
IRF6 interferon regulatory factor 6
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITPKB inositol-trisphosphate 3-kinase B
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA0319L KIAA0319-like
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF8 Kruppel-like factor 8
KLHL25 kelch-like family member 25
LMO7 LIM domain 7
LOC390998 ribosomal protein L10 pseudogene
LRRC37A3 leucine rich repeat containing 37, member A3
MRPL52 mitochondrial ribosomal protein L52
MX2 MX dynamin-like GTPase 2
NSUN6 NOP2/Sun domain family, member 6
OCA2 oculocutaneous albinism II
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PAX9 paired box 9
PLAC4 placenta-specific 4
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHA6 pleckstrin homology domain containing, family A member 6
PROCR protein C receptor, endothelial
PYHIN1 pyrin and HIN domain family, member 1
RAB40C RAB40C, member RAS oncogene family
RPH3A rabphilin 3A
RPL13P5 ribosomal protein L13 pseudogene 5
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SENP7 SUMO1/sentrin specific peptidase 7
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC16A4 solute carrier family 16, member 4
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SPPL2B signal peptide peptidase like 2B
SPRR1B small proline-rich protein 1B
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TFF2 trefoil factor 2
TMEM209 transmembrane protein 209
TMEM242 transmembrane protein 242
TMLHE trimethyllysine hydroxylase, epsilon
TSPYL2 TSPY-like 2
UTRN utrophin
XDH xanthine dehydrogenase
ZBTB22 zinc finger and BTB domain containing 22
ZIC3 Zic family member 3
ZNF37BP zinc finger protein 37B, pseudogene
ZNF639 zinc finger protein 639