ethisterone-4340 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ethisterone-4340 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANGPT1 angiopoietin 1
ANKRD12 ankyrin repeat domain 12
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASAP1-IT1 ASAP1 intronic transcript 1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATXN7L3B ataxin 7-like 3B
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNK cyclin K
CDC14B cell division cycle 14B
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
COL16A1 collagen, type XVI, alpha 1
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DMXL2 Dmx-like 2
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DSC2 desmocollin 2
E2F5 E2F transcription factor 5, p130-binding
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
ERAP1 endoplasmic reticulum aminopeptidase 1
EZR ezrin
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRK fyn-related Src family tyrosine kinase
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8A golgin A8 family, member A
GPATCH4 G patch domain containing 4
GPR137 G protein-coupled receptor 137
GPR22 G protein-coupled receptor 22
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
HCFC1 host cell factor C1
HIST1H1E histone cluster 1, H1e
HIST1H2BB histone cluster 1, H2bb
HRG histidine-rich glycoprotein
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IER3IP1 immediate early response 3 interacting protein 1
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL11 interleukin 11
IL6ST interleukin 6 signal transducer
ING2 inhibitor of growth family, member 2
INO80D INO80 complex subunit D
INSL4 insulin-like 4 (placenta)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIAA0100 KIAA0100
KIF5C kinesin family member 5C
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LGALS8 lectin, galactoside-binding, soluble, 8
LOC157562 uncharacterized LOC157562
LOC390998 ribosomal protein L10 pseudogene
LPP LIM domain containing preferred translocation partner in lipoma
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRRC75B leucine rich repeat containing 75B
LY9 lymphocyte antigen 9
MAK male germ cell-associated kinase
MED18 mediator complex subunit 18
MRPL41 mitochondrial ribosomal protein L41
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NOP14-AS1 NOP14 antisense RNA 1
NPTX1 neuronal pentraxin I
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUMA1 nuclear mitotic apparatus protein 1
NUP54 nucleoporin 54kDa
PCNX pecanex homolog (Drosophila)
PDGFA platelet-derived growth factor alpha polypeptide
PGK1 phosphoglycerate kinase 1
PHF3 PHD finger protein 3
PKP4 plakophilin 4
PMCH pro-melanin-concentrating hormone
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POU3F4 POU class 3 homeobox 4
PVT1 Pvt1 oncogene (non-protein coding)
RAB14 RAB14, member RAS oncogene family
RAB2A RAB2A, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RGS4 regulator of G-protein signaling 4
RPL27A ribosomal protein L27a
RPLP2 ribosomal protein, large, P2
SAFB scaffold attachment factor B
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMG7 SMG7 nonsense mediated mRNA decay factor
TBC1D2B TBC1 domain family, member 2B
TIMELESS timeless circadian clock
TUBGCP2 tubulin, gamma complex associated protein 2
TWF1 twinfilin actin binding protein 1
TXN thioredoxin
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VAMP5 vesicle-associated membrane protein 5
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZFP64 ZFP64 zinc finger protein
ZMYM2 zinc finger, MYM-type 2
ZNF154 zinc finger protein 154
ZNF573 zinc finger protein 573

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTC1 actin, alpha, cardiac muscle 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM23 ADAM metallopeptidase domain 23
APOL6 apolipoprotein L, 6
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARID5A AT rich interactive domain 5A (MRF1-like)
ARMCX4 armadillo repeat containing, X-linked 4
ARR3 arrestin 3, retinal (X-arrestin)
ARRB2 arrestin, beta 2
ATAT1 alpha tubulin acetyltransferase 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAHCC1 BAH domain and coiled-coil containing 1
BEND5 BEN domain containing 5
BEST2 bestrophin 2
C1ORF54 chromosome 1 open reading frame 54
CAPN15 calpain 15
CBX4 chromobox homolog 4
CCDC71 coiled-coil domain containing 71
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD53 CD53 molecule
CEP85 centrosomal protein 85kDa
CHRDL1 chordin-like 1
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLDN1 claudin 1
CUZD1 CUB and zona pellucida-like domains 1
DEAF1 DEAF1 transcription factor
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFHD2 EF-hand domain family, member D2
EHMT1 euchromatic histone-lysine N-methyltransferase 1
FKBP5 FK506 binding protein 5
FLT4 fms-related tyrosine kinase 4
FZD10 frizzled class receptor 10
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRB7 growth factor receptor-bound protein 7
H1F0 H1 histone family, member 0
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HOXA7 homeobox A7
IGFBP4 insulin-like growth factor binding protein 4
IL24 interleukin 24
IL2RG interleukin 2 receptor, gamma
IL4R interleukin 4 receptor
INADL InaD-like (Drosophila)
INO80B INO80 complex subunit B
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM5C lysine (K)-specific demethylase 5C
KLHL25 kelch-like family member 25
KRT8P12 keratin 8 pseudogene 12
LRP4 low density lipoprotein receptor-related protein 4
MORN1 MORN repeat containing 1
MTHFSD methenyltetrahydrofolate synthetase domain containing
NPY6R neuropeptide Y receptor Y6 (pseudogene)
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PADI1 peptidyl arginine deiminase, type I
PAQR5 progestin and adipoQ receptor family member V
PCDH12 protocadherin 12
PICK1 protein interacting with PRKCA 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLA2G1B phospholipase A2, group IB (pancreas)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXNB3 plexin B3
POLL polymerase (DNA directed), lambda
POM121L2 POM121 transmembrane nucleoporin-like 2
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRF1 perforin 1 (pore forming protein)
R3HCC1L R3H domain and coiled-coil containing 1-like
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RFPL1S RFPL1 antisense RNA 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SETD1A SET domain containing 1A
SETD8 SET domain containing (lysine methyltransferase) 8
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SNPH syntaphilin
SOX13 SRY (sex determining region Y)-box 13
SPRR2B small proline-rich protein 2B
SSBP3 single stranded DNA binding protein 3
STRA6 stimulated by retinoic acid 6
SYNGR4 synaptogyrin 4
TBXAS1 thromboxane A synthase 1 (platelet)
TET3 tet methylcytosine dioxygenase 3
TGFBI transforming growth factor, beta-induced, 68kDa
TLN1 talin 1
TMEM212 transmembrane protein 212
TMEM8A transmembrane protein 8A
TSC22D4 TSC22 domain family, member 4
TSPAN32 tetraspanin 32
TUBA4B tubulin, alpha 4b
VLDLR very low density lipoprotein receptor
ZBTB22 zinc finger and BTB domain containing 22
ZC3H12A zinc finger CCCH-type containing 12A
ZNF155 zinc finger protein 155
ZNF43 zinc finger protein 43