etofylline-2256 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the etofylline-2256 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACTL8 actin-like 8
ADGRB2 adhesion G protein-coupled receptor B2
AKAP13 A kinase (PRKA) anchor protein 13
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BEST1 bestrophin 1
BMP10 bone morphogenetic protein 10
C10ORF12 chromosome 10 open reading frame 12
C10ORF95 chromosome 10 open reading frame 95
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CARTPT CART prepropeptide
CCL27 chemokine (C-C motif) ligand 27
CD70 CD70 molecule
CDK6 cyclin-dependent kinase 6
CFAP69 cilia and flagella associated protein 69
CHD5 chromodomain helicase DNA binding protein 5
CLEC1A C-type lectin domain family 1, member A
COL6A1 collagen, type VI, alpha 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DGKG diacylglycerol kinase, gamma 90kDa
DMWD dystrophia myotonica, WD repeat containing
DTNB dystrobrevin, beta
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
ERAP1 endoplasmic reticulum aminopeptidase 1
FCMR Fc fragment of IgM receptor
FGL2 fibrinogen-like 2
FRAS1 Fraser extracellular matrix complex subunit 1
GJA4 gap junction protein, alpha 4, 37kDa
GMPR guanosine monophosphate reductase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HDAC7 histone deacetylase 7
HYAL3 hyaluronoglucosaminidase 3
IFT27 intraflagellar transport 27
IGLV3-19 immunoglobulin lambda variable 3-19
INHBE inhibin, beta E
INSR insulin receptor
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIAA0125 KIAA0125
LAMP1 lysosomal-associated membrane protein 1
LDHB lactate dehydrogenase B
LOC157562 uncharacterized LOC157562
MAGEA3 melanoma antigen family A3
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MBD1 methyl-CpG binding domain protein 1
MFSD6 major facilitator superfamily domain containing 6
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NKX2-8 NK2 homeobox 8
NNAT neuronatin
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRG1 neuregulin 1
NUP50 nucleoporin 50kDa
NUP88 nucleoporin 88kDa
OR10J1 olfactory receptor, family 10, subfamily J, member 1
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARP3 poly (ADP-ribose) polymerase family, member 3
PCDHB12 protocadherin beta 12
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PML promyelocytic leukemia
PRKCI protein kinase C, iota
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RNF126P1 ring finger protein 126 pseudogene 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAFB2 scaffold attachment factor B2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SIRT5 sirtuin 5
SKAP1 src kinase associated phosphoprotein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMR3A submaxillary gland androgen regulated protein 3A
SOX2 SRY (sex determining region Y)-box 2
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPON1 spondin 1, extracellular matrix protein
STAT2 signal transducer and activator of transcription 2, 113kDa
STOML1 stomatin (EPB72)-like 1
TBX5 T-box 5
TLN2 talin 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TP53I11 tumor protein p53 inducible protein 11
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIM29 tripartite motif containing 29
TRIM38 tripartite motif containing 38
TRPC1 transient receptor potential cation channel, subfamily C, member 1
UBA6 ubiquitin-like modifier activating enzyme 6
VIPR1 vasoactive intestinal peptide receptor 1
YTHDC1 YTH domain containing 1
YTHDC2 YTH domain containing 2

decreased expression

Symbol Name
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ARMC4 armadillo repeat containing 4
ASAP1-IT1 ASAP1 intronic transcript 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BHLHE41 basic helix-loop-helix family, member e41
C4ORF29 chromosome 4 open reading frame 29
C7ORF43 chromosome 7 open reading frame 43
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC186 coiled-coil domain containing 186
CCNT1 cyclin T1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD34 CD34 molecule
CD83 CD83 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CES3 carboxylesterase 3
CLIP4 CAP-GLY domain containing linker protein family, member 4
CRIP1 cysteine-rich protein 1 (intestinal)
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSCAM Down syndrome cell adhesion molecule
ERCC6 excision repair cross-complementation group 6
FAM120C family with sequence similarity 120C
FAM186A family with sequence similarity 186, member A
FLJ11710 uncharacterized protein FLJ11710
FOXI1 forkhead box I1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GLRA1 glycine receptor, alpha 1
GLS2 glutaminase 2 (liver, mitochondrial)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GSTCD glutathione S-transferase, C-terminal domain containing
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1D histone cluster 1, H1d
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOOK1 hook microtubule-tethering protein 1
IL12RB1 interleukin 12 receptor, beta 1
ITPKB inositol-trisphosphate 3-kinase B
KDM8 lysine (K)-specific demethylase 8
LNPEP leucyl/cystinyl aminopeptidase
LTBP2 latent transforming growth factor beta binding protein 2
MAGEF1 melanoma antigen family F1
MBTD1 mbt domain containing 1
MED18 mediator complex subunit 18
MFAP2 microfibrillar-associated protein 2
MGC12488
MRPL41 mitochondrial ribosomal protein L41
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTCP1 mature T-cell proliferation 1
NCS1 neuronal calcium sensor 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PCSK7 proprotein convertase subtilisin/kexin type 7
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHA6 pleckstrin homology domain containing, family A member 6
POLL polymerase (DNA directed), lambda
PRR14L proline rich 14-like
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PYCRL pyrroline-5-carboxylate reductase-like
RAB3A RAB3A, member RAS oncogene family
RASL11B RAS-like, family 11, member B
RSF1 remodeling and spacing factor 1
SCAI suppressor of cancer cell invasion
SCN1B sodium channel, voltage gated, type I beta subunit
SECTM1 secreted and transmembrane 1
SETD1A SET domain containing 1A
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SKI SKI proto-oncogene
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SPATA2L spermatogenesis associated 2-like
SPIN1 spindlin 1
SPRYD7 SPRY domain containing 7
STIM1 stromal interaction molecule 1
TBC1D2 TBC1 domain family, member 2
TEX40 testis expressed 40
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM242 transmembrane protein 242
TRIM21 tripartite motif containing 21
TRPV1 transient receptor potential cation channel, subfamily V, member 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VASH2 vasohibin 2
VIM vimentin
WDR91 WD repeat domain 91
WFDC2 WAP four-disulfide core domain 2
ZBTB33 zinc finger and BTB domain containing 33
ZBTB48 zinc finger and BTB domain containing 48
ZNF652 zinc finger protein 652
ZNF669 zinc finger protein 669
ZNF701 zinc finger protein 701
ZNF76 zinc finger protein 76
ZNF862 zinc finger protein 862