etoposide-3241 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the etoposide-3241 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACRV1 acrosomal vesicle protein 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM12 ADAM metallopeptidase domain 12
ALOX5 arachidonate 5-lipoxygenase
ANK1 ankyrin 1, erythrocytic
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
APOH apolipoprotein H (beta-2-glycoprotein I)
ARMCX2 armadillo repeat containing, X-linked 2
ASTN2 astrotactin 2
BAX BCL2-associated X protein
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BLNK B-cell linker
BTG2 BTG family, member 2
BUD31 BUD31 homolog (S. cerevisiae)
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALD1 caldesmon 1
CARF calcium responsive transcription factor
CCRL2 chemokine (C-C motif) receptor-like 2
CDK13 cyclin-dependent kinase 13
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEL carboxyl ester lipase
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CST1 cystatin SN
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYHR1 cysteine/histidine-rich 1
DDIT4 DNA-damage-inducible transcript 4
DNM3 dynamin 3
EDNRA endothelin receptor type A
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FGD1 FYVE, RhoGEF and PH domain containing 1
FOSL1 FOS-like antigen 1
FSTL4 follistatin-like 4
GADD45A growth arrest and DNA-damage-inducible, alpha
GLRA1 glycine receptor, alpha 1
GLS2 glutaminase 2 (liver, mitochondrial)
GMPR guanosine monophosphate reductase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR161 G protein-coupled receptor 161
GPR87 G protein-coupled receptor 87
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPG2 heparan sulfate proteoglycan 2
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IRAK3 interleukin-1 receptor-associated kinase 3
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KANK3 KN motif and ankyrin repeat domains 3
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
LIF leukemia inhibitory factor
LIG3 ligase III, DNA, ATP-dependent
LY6D lymphocyte antigen 6 complex, locus D
MAN2A2 mannosidase, alpha, class 2A, member 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MST1 macrophage stimulating 1
NCOR2 nuclear receptor corepressor 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
ORAI3 ORAI calcium release-activated calcium modulator 3
PBX2 pre-B-cell leukemia homeobox 2
PDE4C phosphodiesterase 4C, cAMP-specific
PER1 period circadian clock 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPEF1 protein phosphatase, EF-hand calcium binding domain 1
PROCR protein C receptor, endothelial
PRODH proline dehydrogenase (oxidase) 1
PROL1 proline rich, lacrimal 1
PRR34 proline rich 34
PTK6 protein tyrosine kinase 6
SAA4 serum amyloid A4, constitutive
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SRCAP Snf2-related CREBBP activator protein
TCP11L1 t-complex 11, testis-specific-like 1
TMEM242 transmembrane protein 242
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TP53I3 tumor protein p53 inducible protein 3
TP53TG1 TP53 target 1 (non-protein coding)
TSPAN9 tetraspanin 9
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
WDFY3 WD repeat and FYVE domain containing 3
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZFAND5 zinc finger, AN1-type domain 5
ZFHX4 zinc finger homeobox 4
ZFP2 ZFP2 zinc finger protein
ZMAT3 zinc finger, matrin-type 3
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
ARMC6 armadillo repeat containing 6
ARPIN actin-related protein 2/3 complex inhibitor
ART1 ADP-ribosyltransferase 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKB aurora kinase B
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BMP4 bone morphogenetic protein 4
BORA bora, aurora kinase A activator
BRCA2 breast cancer 2, early onset
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C1ORF159 chromosome 1 open reading frame 159
C9ORF9 chromosome 9 open reading frame 9
CCDC85C coiled-coil domain containing 85C
CCDC9 coiled-coil domain containing 9
CCNA2 cyclin A2
CCNB1 cyclin B1
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK20 cyclin-dependent kinase 20
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPI centromere protein I
CEP55 centrosomal protein 55kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLIP4 CAP-GLY domain containing linker protein family, member 4
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
DAGLA diacylglycerol lipase, alpha
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEPDC1 DEP domain containing 1
DGAT1 diacylglycerol O-acyltransferase 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ERN2 endoplasmic reticulum to nucleus signaling 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM64A family with sequence similarity 64, member A
FOXN2 forkhead box N2
GIF gastric intrinsic factor (vitamin B synthesis)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPC3 glypican 3
HIST2H2AA3 histone cluster 2, H2aa3
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IDI2-AS1 IDI2 antisense RNA 1
IL17RB interleukin 17 receptor B
IPO8 importin 8
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KREMEN2 kringle containing transmembrane protein 2
LDHB lactate dehydrogenase B
LMNB1 lamin B1
LOC730101 uncharacterized LOC730101
LYZ lysozyme
LZTS3 leucine zipper, putative tumor suppressor family member 3
MGC12488
MXD3 MAX dimerization protein 3
MYO1E myosin IE
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NDE1 nudE neurodevelopment protein 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NMU neuromedin U
PARD6A par-6 family cell polarity regulator alpha
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PLK1 polo-like kinase 1
POMT2 protein-O-mannosyltransferase 2
PRC1 protein regulator of cytokinesis 1
PSRC1 proline/serine-rich coiled-coil 1
PTPN14 protein tyrosine phosphatase, non-receptor type 14
QPCTL glutaminyl-peptide cyclotransferase-like
RANBP17 RAN binding protein 17
RBL1 retinoblastoma-like 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RIBC2 RIB43A domain with coiled-coils 2
RNF122 ring finger protein 122
SMYD5 SMYD family member 5
TACC3 transforming, acidic coiled-coil containing protein 3
TESC tescalcin
TMEM180 transmembrane protein 180
TPX2 TPX2, microtubule-associated
TROAP trophinin associated protein
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
WDR62 WD repeat domain 62
ZNF165 zinc finger protein 165
ZNF442 zinc finger protein 442
ZNF675 zinc finger protein 675