etoposide-6681 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the etoposide-6681 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADAM3A ADAM metallopeptidase domain 3A (pseudogene)
ADCY2 adenylate cyclase 2 (brain)
ADRA1A adrenoceptor alpha 1A
ANGEL2 angel homolog 2 (Drosophila)
APAF1 apoptotic peptidase activating factor 1
ARHGAP28 Rho GTPase activating protein 28
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BDKRB1 bradykinin receptor B1
C10ORF10 chromosome 10 open reading frame 10
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCNO cyclin O
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEMP1 cementum protein 1
CLIC5 chloride intracellular channel 5
CNTNAP2 contactin associated protein-like 2
COL6A1 collagen, type VI, alpha 1
CPB2 carboxypeptidase B2 (plasma)
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DBF4B DBF4 zinc finger B
DCLK2 doublecortin-like kinase 2
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DPY19L1 dpy-19-like 1 (C. elegans)
EDRF1 erythroid differentiation regulatory factor 1
FAM174B family with sequence similarity 174, member B
FGF20 fibroblast growth factor 20
FGF21 fibroblast growth factor 21
FGF4 fibroblast growth factor 4
FLT3LG fms-related tyrosine kinase 3 ligand
FSCN3 fascin actin-bundling protein 3, testicular
FUT2 fucosyltransferase 2 (secretor status included)
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GSN gelsolin
HABP4 hyaluronan binding protein 4
HAP1 huntingtin-associated protein 1
HIST1H2AL histone cluster 1, H2al
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXB2 homeobox B2
IFFO1 intermediate filament family orphan 1
IL19 interleukin 19
IL2RG interleukin 2 receptor, gamma
IMPG2 interphotoreceptor matrix proteoglycan 2
IRF4 interferon regulatory factor 4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KLF13 Kruppel-like factor 13
KLHL22 kelch-like family member 22
KLHL25 kelch-like family member 25
LGALS2 lectin, galactoside-binding, soluble, 2
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LRRN3 leucine rich repeat neuronal 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MTCP1 mature T-cell proliferation 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NCAM1 neural cell adhesion molecule 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIPAL2 NIPA-like domain containing 2
NPY neuropeptide Y
NRIP3 nuclear receptor interacting protein 3
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OMG oligodendrocyte myelin glycoprotein
OR2B2 olfactory receptor, family 2, subfamily B, member 2
OXCT2 3-oxoacid CoA transferase 2
PAOX polyamine oxidase (exo-N4-amino)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX8 paired box 8
PBOV1 prostate and breast cancer overexpressed 1
PDE12 phosphodiesterase 12
PEX5L peroxisomal biogenesis factor 5-like
PRKG1 protein kinase, cGMP-dependent, type I
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRR protein tyrosine phosphatase, receptor type, R
RAP2B RAP2B, member of RAS oncogene family
RB1 retinoblastoma 1
RFXAP regulatory factor X-associated protein
RGS17 regulator of G-protein signaling 17
SCARB1 scavenger receptor class B, member 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC39A9 solute carrier family 39, member 9
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SULT4A1 sulfotransferase family 4A, member 1
TCEAL2 transcription elongation factor A (SII)-like 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRAPPC9 trafficking protein particle complex 9
TRIL TLR4 interactor with leucine-rich repeats
USP29 ubiquitin specific peptidase 29
ZFPL1 zinc finger protein-like 1
ZNF573 zinc finger protein 573
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACSL5 acyl-CoA synthetase long-chain family member 5
ALOX12 arachidonate 12-lipoxygenase
ALPK1 alpha-kinase 1
AMT aminomethyltransferase
ANKRD36 ankyrin repeat domain 36
APOLD1 apolipoprotein L domain containing 1
ARSJ arylsulfatase family, member J
ATAT1 alpha tubulin acetyltransferase 1
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF93 chromosome 14 open reading frame 93
C1ORF159 chromosome 1 open reading frame 159
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC132 coiled-coil domain containing 132
CCNJL cyclin J-like
CD82 CD82 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CIDEC cell death-inducing DFFA-like effector c
CLEC2B C-type lectin domain family 2, member B
CNGB3 cyclic nucleotide gated channel beta 3
DDN dendrin
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DTX2 deltex 2, E3 ubiquitin ligase
EPHX2 epoxide hydrolase 2, cytoplasmic
ERF Ets2 repressor factor
FAT4 FAT atypical cadherin 4
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FHOD3 formin homology 2 domain containing 3
FRS2 fibroblast growth factor receptor substrate 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GK3P glycerol kinase 3 pseudogene
GLS2 glutaminase 2 (liver, mitochondrial)
GPC3 glypican 3
GRM4 glutamate receptor, metabotropic 4
H2AFJ H2A histone family, member J
HDAC11 histone deacetylase 11
HIST1H2AK histone cluster 1, H2ak
HIST1H2BN histone cluster 1, H2bn
HLX H2.0-like homeobox
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IFI6 interferon, alpha-inducible protein 6
IQSEC2 IQ motif and Sec7 domain 2
JAM3 junctional adhesion molecule 3
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KCTD17 potassium channel tetramerization domain containing 17
KIAA1456 KIAA1456
KPTN kaptin (actin binding protein)
KRT37 keratin 37, type I
LIFR leukemia inhibitory factor receptor alpha
LOC257152 uncharacterized LOC257152
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYRM9 LYR motif containing 9
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MCTP2 multiple C2 domains, transmembrane 2
MEX3C mex-3 RNA binding family member C
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MXD3 MAX dimerization protein 3
MYO1F myosin IF
NDP Norrie disease (pseudoglioma)
NOL10 nucleolar protein 10
NOTCH1 notch 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PICK1 protein interacting with PRKCA 1
POMT2 protein-O-mannosyltransferase 2
PPP1R26 protein phosphatase 1, regulatory subunit 26
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PROX1 prospero homeobox 1
PTK6 protein tyrosine kinase 6
RSBN1 round spermatid basic protein 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SOX12 SRY (sex determining region Y)-box 12
SPTBN2 spectrin, beta, non-erythrocytic 2
SREBF1 sterol regulatory element binding transcription factor 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUGCT succinyl-CoA:glutarate-CoA transferase
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYCP2 synaptonemal complex protein 2
TAGLN transgelin
TBC1D22B TBC1 domain family, member 22B
TGFBI transforming growth factor, beta-induced, 68kDa
TINAGL1 tubulointerstitial nephritis antigen-like 1
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRAIP TRAF interacting protein
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TUBA4B tubulin, alpha 4b
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZFP30 ZFP30 zinc finger protein
ZNF141 zinc finger protein 141
ZNF391 zinc finger protein 391
ZNF571 zinc finger protein 571