extramedullary hematopoiesis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description The process of hematopoiesis occurring outside of the bone marrow (in the liver, thymus, and spleen) in the postnatal organisms. (Human Phenotype Ontology, HP_0001978)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000240
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Genes

100 gene mutations causing the extramedullary hematopoiesis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADA adenosine deaminase
AHR aryl hydrocarbon receptor
ANK1 ankyrin 1, erythrocytic
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID4A AT rich interactive domain 4A (RBP1-like)
ASXL1 additional sex combs like transcriptional regulator 1
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BCL2L1 BCL2-like 1
BIN3 bridging integrator 3
C6ORF25 chromosome 6 open reading frame 25
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBFB core-binding factor, beta subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCNE1 cyclin E1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHD2 chromodomain helicase DNA binding protein 2
CREBBP CREB binding protein
CSF1 colony stimulating factor 1 (macrophage)
CTSG cathepsin G
CXCR2 chemokine (C-X-C motif) receptor 2
DCK deoxycytidine kinase
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DIAPH1 diaphanous-related formin 1
DIAPH3 diaphanous-related formin 3
DKC1 dyskeratosis congenita 1, dyskerin
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EPB41 erythrocyte membrane protein band 4.1
ERAP1 endoplasmic reticulum aminopeptidase 1
ESRRA estrogen-related receptor alpha
FAM20C family with sequence similarity 20, member C
FBXO4 F-box protein 4
FLT3 fms-related tyrosine kinase 3
FOXP3 forkhead box P3
GATA1 GATA binding protein 1 (globin transcription factor 1)
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
HMOX1 heme oxygenase 1
IFNG interferon, gamma
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10RB interleukin 10 receptor, beta
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
JAK2 Janus kinase 2
KRT8 keratin 8, type II
LGMN legumain
LYN LYN proto-oncogene, Src family tyrosine kinase
MZF1 myeloid zinc finger 1
NCKAP1L NCK-associated protein 1-like
NCOR2 nuclear receptor corepressor 2
NDFIP1 Nedd4 family interacting protein 1
NEU1 sialidase 1 (lysosomal sialidase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH1 notch 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PGM3 phosphoglucomutase 3
PHC1 polyhomeotic homolog 1 (Drosophila)
PPT2 palmitoyl-protein thioesterase 2
PRDX1 peroxiredoxin 1
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTCH2 patched 2
PTPRC protein tyrosine phosphatase, receptor type, C
RBL1 retinoblastoma-like 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RUNX2 runt-related transcription factor 2
SELL selectin L
SH2B3 SH2B adaptor protein 3
SHARPIN SHANK-associated RH domain interactor
SIPA1 signal-induced proliferation-associated 1
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SMAD3 SMAD family member 3
SOCS1 suppressor of cytokine signaling 1
SOS1 son of sevenless homolog 1 (Drosophila)
SPTA1 spectrin, alpha, erythrocytic 1
SPTB spectrin, beta, erythrocytic
STEAP3 STEAP family member 3, metalloreductase
TAL1 T-cell acute lymphocytic leukemia 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TET2 tet methylcytosine dioxygenase 2
TMPRSS6 transmembrane protease, serine 6
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TPP2 tripeptidyl peptidase II
TSPAN33 tetraspanin 33
TTC7A tetratricopeptide repeat domain 7A
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPM1 zinc finger protein, FOG family member 1