ezh2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description enhancer of zeste 2 polycomb repressive complex 2 subunit|This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 2146)
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Genes

140 genes co-occuring with the biological term ezh2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APAF1 apoptotic peptidase activating factor 1
AR androgen receptor
ARRB1 arrestin, beta 1
ASXL1 additional sex combs like transcriptional regulator 1
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASZ1 castor zinc finger 1
CCND1 cyclin D1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDYL chromodomain protein, Y-like
CLU clusterin
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CXXC4 CXXC finger protein 4
DAB2IP DAB2 interacting protein
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
E2F1 E2F transcription factor 1
E2F6 E2F transcription factor 6
EED embryonic ectoderm development
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EWSR1 EWS RNA-binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBXO32 F-box protein 32
FEZF2 FEZ family zinc finger 2
FLNC filamin C, gamma
FOXO1 forkhead box O1
GAGE2A G antigen 2A
GAGE2C G antigen 2C
GSK3B glycogen synthase kinase 3 beta
H19 H19, imprinted maternally expressed transcript (non-protein coding)
H3F3A H3 histone, family 3A
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HIST2H2BE histone cluster 2, H2be
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA6 integrin, alpha 6
JAK2 Janus kinase 2
KDM6A lysine (K)-specific demethylase 6A
KRAS Kirsten rat sarcoma viral oncogene homolog
LCN2 lipocalin 2
LMX1A LIM homeobox transcription factor 1, alpha
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR101-1 microRNA 101-1
MIR101-2 microRNA 101-2
MIR124-1 microRNA 124-1
MIR128-1 microRNA 128-1
MIR137 microRNA 137
MIR138-1 microRNA 138-1
MIR138-2 microRNA 138-2
MIR144 microRNA 144
MIR214 microRNA 214
MIR26A1 microRNA 26a-1
MIR29A microRNA 29a
MIR31 microRNA 31
MIRLET7A1 microRNA let-7a-1
MITF microphthalmia-associated transcription factor
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MSMB microseminoprotein, beta-
MST1 macrophage stimulating 1
MTDH metadherin
MUC1 mucin 1, cell surface associated
MUC6 mucin 6, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
NKX3-1 NK3 homeobox 1
NOTCH1 notch 1
NSD1 nuclear receptor binding SET domain protein 1
PAX3 paired box 3
PAX8 paired box 8
PEBP1 phosphatidylethanolamine binding protein 1
PHB2 prohibitin 2
PHF1 PHD finger protein 1
PHF19 PHD finger protein 19
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
POU3F3 POU class 3 homeobox 3
PPP1R8 protein phosphatase 1, regulatory subunit 8
PRB2 proline-rich protein BstNI subfamily 2
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PXN paxillin
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1GAP RAP1 GTPase activating protein
RB1 retinoblastoma 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RING1 ring finger protein 1
RNF2 ring finger protein 2
RORA RAR-related orphan receptor A
RUNX2 runt-related transcription factor 2
RUNX3 runt-related transcription factor 3
SAFB scaffold attachment factor B
SAPCD2 suppressor APC domain containing 2
SATB1 SATB homeobox 1
SIRT1 sirtuin 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SMYD3 SET and MYND domain containing 3
SNAI1 snail family zinc finger 1
SP1 Sp1 transcription factor
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TET1 tet methylcytosine dioxygenase 1
TET2 tet methylcytosine dioxygenase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMPOP2 thymopoietin pseudogene 2 (functional)
TP53 tumor protein p53
TP73 tumor protein p73
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor