fact complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer. (Gene Ontology, GO_0035101)
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Genes

66 proteins co-occuring with the fact complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SSRP1 structure specific recognition protein 1 2.18521
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing 1.17055
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 1.15979
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) 1.10205
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 1.08425
H2AFB2 H2A histone family, member B2 0.942584
HIST1H2AJ histone cluster 1, H2aj 0.872726
H2AFJ H2A histone family, member J 0.872726
HIST1H2AD histone cluster 1, H2ad 0.872726
HIST1H2AM histone cluster 1, H2am 0.872726
HIST1H2AH histone cluster 1, H2ah 0.872266
HIST1H2AG histone cluster 1, H2ag 0.870885
H2AFY2 H2A histone family, member Y2 0.869046
HIST1H2AE histone cluster 1, H2ae 0.868126
HIST1H2AB histone cluster 1, H2ab 0.868126
H2AFV H2A histone family, member V 0.867666
H2AFB1 H2A histone family, member B1 0.864447
H2AFY H2A histone family, member Y 0.856176
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.841482
TCEA2 transcription elongation factor A (SII), 2 0.823582
HIST2H2AC histone cluster 2, H2ac 0.796979
HIST2H2AA3 histone cluster 2, H2aa3 0.79652
HIST2H2AA4 histone cluster 2, H2aa4 0.79652
AICDA activation-induced cytidine deaminase 0.766804
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 0.759524
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 0.756799
CENPH centromere protein H 0.683771
CENPL centromere protein L 0.657326
CENPQ centromere protein Q 0.653019
H3F3B H3 histone, family 3B (H3.3B) 0.610355
H3F3A H3 histone, family 3A 0.610355
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.601066
CENPN centromere protein N 0.598538
SETX senataxin 0.568832
CENPU centromere protein U 0.553491
NEK9 NIMA-related kinase 9 0.503099
HIST3H2BB histone cluster 3, H2bb 0.486904
HIST2H2BF histone cluster 2, H2bf 0.486904
HIST1H2BH histone cluster 1, H2bh 0.486904
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.4865
HIST1H2BD histone cluster 1, H2bd 0.4865
HIST1H2BC histone cluster 1, H2bc 0.485289
HIST1H2BF histone cluster 1, H2bf 0.485289
HIST1H2BA histone cluster 1, H2ba 0.484079
MRC1 mannose receptor, C type 1 0.468401
GTF2B general transcription factor IIB 0.456012
NUCLEOLIN nucleolin multifunctional protein 0.414555
CENPT centromere protein T 0.408699
TERF2 telomeric repeat binding factor 2 0.368536
MCM5 minichromosome maintenance complex component 5 0.357467
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.355944
MKL1 megakaryoblastic leukemia (translocation) 1 0.347587
MCM10 minichromosome maintenance complex component 10 0.324951
HAT1 histone acetyltransferase 1 0.320826
CDK9 cyclin-dependent kinase 9 0.28846
CHD1 chromodomain helicase DNA binding protein 1 0.253291
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.246769
SETD2 SET domain containing 2 0.230958
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.200663
ACLY ATP citrate lyase 0.181823
APITD1 apoptosis-inducing, TAF9-like domain 1 0.174087
CDC7 cell division cycle 7 0.172201
MYOCD myocardin 0.168598
SLK STE20-like kinase 0.165231
SETD1A SET domain containing 1A 0.159268
GMNN geminin, DNA replication inhibitor 0.15776