| Dataset | GO Biological Process Annotations 2015 |
| Category | structural or functional annotations |
| Type | biological process |
| Description | Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade. (Gene Ontology, GO_0002542) |
| External Link | http://amigo.geneontology.org/amigo/term/GO:0002542 |
| Similar Terms | |
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2 genes participating in the factor xii activation biological process from the curated GO Biological Process Annotations 2015 dataset.
