fadd Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Fas (TNFRSF6)-associated via death domain|The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8772)
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Genes

40 genes co-occuring with the biological term fadd in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AK2 adenylate kinase 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATG5 autophagy related 5
AURKA aurora kinase A
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CFLAR CASP8 and FADD-like apoptosis regulator
CIDEC cell death-inducing DFFA-like effector c
CXCL8 chemokine (C-X-C motif) ligand 8
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FGF3 fibroblast growth factor 3
FHIT fragile histidine triad
GZMM granzyme M (lymphocyte met-ase 1)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK3 homeodomain interacting protein kinase 3
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
IFNG interferon, gamma
MADD MAP-kinase activating death domain
MAPK8 mitogen-activated protein kinase 8
MIR155 microRNA 155
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PEA15 phosphoprotein enriched in astrocytes 15
PLK1 polo-like kinase 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
RTN3 reticulon 3
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
TERT telomerase reverse transcriptase
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRIM21 tripartite motif containing 21
WT1 Wilms tumor 1