fancd2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Fanconi anemia, complementation group D2|The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2177)
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Genes

39 genes co-occuring with the biological term fancd2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ATR ATR serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C1ORF86 chromosome 1 open reading frame 86
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHEK1 checkpoint kinase 1
DCLRE1B DNA cross-link repair 1B
DNA2 DNA replication helicase/nuclease 2
ERCC1 excision repair cross-complementation group 1
EXO1 exonuclease 1
FAN1 FANCD2/FANCI-associated nuclease 1
FANCB Fanconi anemia, complementation group B
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCE Fanconi anemia, complementation group E
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FANCL Fanconi anemia, complementation group L
FANCM Fanconi anemia, complementation group M
FOXO3 forkhead box O3
KAT5 K(lysine) acetyltransferase 5
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN nibrin
NQO1 NAD(P)H dehydrogenase, quinone 1
PALB2 partner and localizer of BRCA2
PCNA proliferating cell nuclear antigen
POLH polymerase (DNA directed), eta
RAD18 RAD18 E3 ubiquitin protein ligase
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RBBP8 retinoblastoma binding protein 8
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
TNF tumor necrosis factor
UBE2A ubiquitin-conjugating enzyme E2A
UBE2T ubiquitin-conjugating enzyme E2T
UBE2W ubiquitin-conjugating enzyme E2W (putative)
USP1 ubiquitin specific peptidase 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3