fas Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Fas cell surface death receptor|The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011] (NCBI Entrez Gene Database, 355)
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Genes

213 genes co-occuring with the biological term fas in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AFP alpha-fetoprotein
ANGPTL4 angiopoietin-like 4
APAF1 apoptotic peptidase activating factor 1
APP amyloid beta (A4) precursor protein
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB1 cyclin B1
CCND1 cyclin D1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD63 CD63 molecule
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFLAR CASP8 and FADD-like apoptosis regulator
CHIA chitinase, acidic
CIDEA cell death-inducing DFFA-like effector a
CPT1A carnitine palmitoyltransferase 1A (liver)
CPT2 carnitine palmitoyltransferase 2
CR2 complement component (3d/Epstein Barr virus) receptor 2
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DAXX death-domain associated protein
DGAT1 diacylglycerol O-acyltransferase 1
DNASE1 deoxyribonuclease I
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELAVL1 ELAV like RNA binding protein 1
EOMES eomesodermin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ETV6 ets variant 6
EZR ezrin
F13A1 coagulation factor XIII, A1 polypeptide
FABP3 fatty acid binding protein 3, muscle and heart
FADD Fas (TNFRSF6)-associated via death domain
FAF1 Fas (TNFRSF6) associated factor 1
FAIM Fas apoptotic inhibitory molecule
FAIM2 Fas apoptotic inhibitory molecule 2
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FASTK Fas-activated serine/threonine kinase
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCMR Fc fragment of IgM receptor
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO3 forkhead box O3
FYN FYN proto-oncogene, Src family tyrosine kinase
GAST gastrin
GORASP1 golgi reassembly stacking protein 1, 65kDa
GPC3 glypican 3
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIPK3 homeodomain interacting protein kinase 3
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HSF1 heat shock transcription factor 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IL10 interleukin 10
IL18R1 interleukin 18 receptor 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2RA interleukin 2 receptor, alpha
IL32 interleukin 32
IL6 interleukin 6
IRS1 insulin receptor substrate 1
ITGAV integrin, alpha V
JUN jun proto-oncogene
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
LAMP1 lysosomal-associated membrane protein 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LIMS1 LIM and senescent cell antigen-like domains 1
LMNA lamin A/C
LPL lipoprotein lipase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAX MYC associated factor X
MET MET proto-oncogene, receptor tyrosine kinase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIR106A microRNA 106a
MIR20A microRNA 20a
MIR23A microRNA 23a
MIR663A microRNA 663a
MIR98 microRNA 98
MIRLET7A1 microRNA let-7a-1
MLXIPL MLX interacting protein-like
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSN moesin
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
MYH9 myosin, heavy chain 9, non-muscle
NCAM1 neural cell adhesion molecule 1
NCR1 natural cytotoxicity triggering receptor 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOS2 nitric oxide synthase 2, inducible
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR5A2 nuclear receptor subfamily 5, group A, member 2
NUCLEOLIN nucleolin multifunctional protein
OGG1 8-oxoguanine DNA glycosylase
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAEP progestagen-associated endometrial protein
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD6 programmed cell death 6
PEA15 phosphoprotein enriched in astrocytes 15
PGF placental growth factor
PML promyelocytic leukemia
PPARD peroxisome proliferator-activated receptor delta
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRF1 perforin 1 (pore forming protein)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTEN phosphatase and tensin homolog
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RARA retinoic acid receptor, alpha
RBM10 RNA binding motif protein 10
RDX radixin
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOBTB2 Rho-related BTB domain containing 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RUNX1 runt-related transcription factor 1
RXRA retinoid X receptor, alpha
S100P S100 calcium binding protein P
SBDS Shwachman-Bodian-Diamond syndrome
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SH2D1A SH2 domain containing 1A
SHH sonic hedgehog
SNAI1 snail family zinc finger 1
SOCS3 suppressor of cytokine signaling 3
SOD1 superoxide dismutase 1, soluble
SP1 Sp1 transcription factor
SREBF1 sterol regulatory element binding transcription factor 1
SSB Sjogren syndrome antigen B (autoantigen La)
SST somatostatin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TFF3 trefoil factor 3 (intestinal)
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TLN1 talin 1
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMSB4X thymosin beta 4, X-linked
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TRIM21 tripartite motif containing 21
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TXN2 thioredoxin 2
U2AF2 U2 small nuclear RNA auxiliary factor 2
ULBP2 UL16 binding protein 2
UNC13D unc-13 homolog D (C. elegans)
VCAM1 vascular cell adhesion molecule 1
VCL vinculin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YY1 YY1 transcription factor
ZFYVE21 zinc finger, FYVE domain containing 21
ZYX zyxin