fas Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Fas cell surface death receptor|The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011] (NCBI Entrez Gene Database, 355)
Similar Terms
Downloads & Tools

Genes

58 proteins co-occuring with the biological term fas in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BCAR1 breast cancer anti-estrogen resistance 1
BCL2 B-cell CLL/lymphoma 2
CASP6 caspase 6, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CDK1 cyclin-dependent kinase 1
CDK11B cyclin-dependent kinase 11B
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CREB1 cAMP responsive element binding protein 1
CTTN cortactin
DAPK2 death-associated protein kinase 2
DAXX death-domain associated protein
DNM2 dynamin 2
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASN fatty acid synthase
FOXO3 forkhead box O3
HIST3H2BA histone cluster 3, H2ba, pseudogene
IL6ST interleukin 6 signal transducer
IRF8 interferon regulatory factor 8
JUN jun proto-oncogene
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LPXN leupaxin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAX MYC associated factor X
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PNPLA2 patatin-like phospholipase domain containing 2
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRL prolactin
PTK2 protein tyrosine kinase 2
PXN paxillin
RB1 retinoblastoma 1
RBM17 RNA binding motif protein 17
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
TP53 tumor protein p53
TRIP6 thyroid hormone receptor interactor 6
TRPM7 transient receptor potential cation channel, subfamily M, member 7
USF1 upstream transcription factor 1
VCL vinculin