Fasciculations are observed as small, local, involuntary muscle contractions (twitching) visible under the skin. Fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron). This leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units. (Human Phenotype Ontology, HP_0002380)
34 genes associated with the fasciculations phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.
