fasudil-343 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the fasudil-343 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANKRD40 ankyrin repeat domain 40
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
BAIAP2 BAI1-associated protein 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCLAF1 BCL2-associated transcription factor 1
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C16ORF58 chromosome 16 open reading frame 58
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCDC7 coiled-coil domain containing 7
CD5 CD5 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHRM4 cholinergic receptor, muscarinic 4
CIDEB cell death-inducing DFFA-like effector b
CLDN15 claudin 15
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CORO2A coronin, actin binding protein, 2A
CPNE7 copine VII
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CUL4B cullin 4B
DBR1 debranching RNA lariats 1
ELAVL4 ELAV like neuron-specific RNA binding protein 4
ELMO2 engulfment and cell motility 2
ERCC4 excision repair cross-complementation group 4
FAM153A family with sequence similarity 153, member A
FAM175B family with sequence similarity 175, member B
FGFR1 fibroblast growth factor receptor 1
FUT2 fucosyltransferase 2 (secretor status included)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GAS7 growth arrest-specific 7
GLMN glomulin, FKBP associated protein
GRIK5 glutamate receptor, ionotropic, kainate 5
GRPR gastrin-releasing peptide receptor
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HEG1 heart development protein with EGF-like domains 1
HEXA hexosaminidase A (alpha polypeptide)
HINFP histone H4 transcription factor
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HUS1 HUS1 checkpoint homolog (S. pombe)
IL15RA interleukin 15 receptor, alpha
IL1B interleukin 1, beta
IL6ST interleukin 6 signal transducer
JADE3 jade family PHD finger 3
JOSD1 Josephin domain containing 1
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KMT2A lysine (K)-specific methyltransferase 2A
LINC00216 long intergenic non-protein coding RNA 216
LUZP4 leucine zipper protein 4
MAGEA5 melanoma antigen family A5
MEFV Mediterranean fever
MTCP1 mature T-cell proliferation 1
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYL10 myosin, light chain 10, regulatory
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NACA nascent polypeptide-associated complex alpha subunit
NAP1L1 nucleosome assembly protein 1-like 1
NOVA1 neuro-oncological ventral antigen 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUP188 nucleoporin 188kDa
OR10H3 olfactory receptor, family 10, subfamily H, member 3
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
ORAI2 ORAI calcium release-activated calcium modulator 2
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PEX11A peroxisomal biogenesis factor 11 alpha
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
QSER1 glutamine and serine rich 1
RHOBTB3 Rho-related BTB domain containing 3
RPS2 ribosomal protein S2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A3 S100 calcium binding protein A3
SCD5 stearoyl-CoA desaturase 5
SEC23B Sec23 homolog B (S. cerevisiae)
SEC63 SEC63 homolog (S. cerevisiae)
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SETD4 SET domain containing 4
SH3BP2 SH3-domain binding protein 2
SNRPN small nuclear ribonucleoprotein polypeptide N
SOD2 superoxide dismutase 2, mitochondrial
SON SON DNA binding protein
SPEG SPEG complex locus
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOB2 transducer of ERBB2, 2
TOLLIP toll interacting protein
TRAFD1 TRAF-type zinc finger domain containing 1
TRBC1 T cell receptor beta constant 1
TRIM2 tripartite motif containing 2
TRIP11 thyroid hormone receptor interactor 11
TYR tyrosinase
UBE4B ubiquitination factor E4B
WDR18 WD repeat domain 18
WWTR1 WW domain containing transcription regulator 1
ZNF154 zinc finger protein 154

decreased expression

Symbol Name
ADAM30 ADAM metallopeptidase domain 30
ADGRE1 adhesion G protein-coupled receptor E1
AXIN1 axin 1
BTBD2 BTB (POZ) domain containing 2
C16ORF59 chromosome 16 open reading frame 59
C19ORF73 chromosome 19 open reading frame 73
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2CD2 C2 calcium-dependent domain containing 2
CAMKMT calmodulin-lysine N-methyltransferase
CBX7 chromobox homolog 7
CBX8 chromobox homolog 8
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD2 CD2 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLEC4E C-type lectin domain family 4, member E
CNTD2 cyclin N-terminal domain containing 2
CNTN1 contactin 1
CRYGB crystallin, gamma B
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DYSF dysferlin
ECM1 extracellular matrix protein 1
EGFL7 EGF-like-domain, multiple 7
EN2 engrailed homeobox 2
ERO1L ERO1-like (S. cerevisiae)
EVPL envoplakin
F2 coagulation factor II (thrombin)
FAM171A1 family with sequence similarity 171, member A1
FOXC1 forkhead box C1
GAB2 GRB2-associated binding protein 2
GMIP GEM interacting protein
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
IFNA4 interferon, alpha 4
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLF11 Kruppel-like factor 11
KLF15 Kruppel-like factor 15
KLHL26 kelch-like family member 26
KREMEN2 kringle containing transmembrane protein 2
KRI1 KRI1 homolog (S. cerevisiae)
LMTK1 lemur tail kinase 1
LRRC49 leucine rich repeat containing 49
LRRC61 leucine rich repeat containing 61
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MECR mitochondrial trans-2-enoyl-CoA reductase
MEPE matrix extracellular phosphoglycoprotein
MFSD12 major facilitator superfamily domain containing 12
MIP major intrinsic protein of lens fiber
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NDRG4 NDRG family member 4
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NEUROD6 neuronal differentiation 6
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NR0B2 nuclear receptor subfamily 0, group B, member 2
NRSN2 neurensin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PCDHB6 protocadherin beta 6
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLCD1 phospholipase C, delta 1
PQLC3 PQ loop repeat containing 3
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRY PTPN13-like, Y-linked
RASL12 RAS-like, family 12
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
RNF186 ring finger protein 186
S100A9 S100 calcium binding protein A9
SCN5A sodium channel, voltage gated, type V alpha subunit
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMA4 glucuronidase, beta pseudogene
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNTA1 syntrophin, alpha 1
STAC SH3 and cysteine rich domain
SULT4A1 sulfotransferase family 4A, member 1
SURF2 surfeit 2
T T, brachyury homolog (mouse)
TCEA2 transcription elongation factor A (SII), 2
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TCTN1 tectonic family member 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM176A transmembrane protein 176A
TMEM53 transmembrane protein 53
TMEM57 transmembrane protein 57
TNF tumor necrosis factor
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTR transthyretin
VEGFB vascular endothelial growth factor B
VIPR1 vasoactive intestinal peptide receptor 1
WDR13 WD repeat domain 13
WNT3 wingless-type MMTV integration site family, member 3
XYLT2 xylosyltransferase II
ZCCHC6 zinc finger, CCHC domain containing 6
ZFP36 ZFP36 ring finger protein
ZIC1 Zic family member 1
ZNF701 zinc finger protein 701