fbxw7 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase|This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 55294)
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Genes

39 genes co-occuring with the biological term fbxw7 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ATM ATM serine/threonine kinase
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
CCDC6 coiled-coil domain containing 6
CCNE1 cyclin E1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CREB3L1 cAMP responsive element binding protein 3-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CXCR4 chemokine (C-X-C motif) receptor 4
ESR1 estrogen receptor 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOXC1 forkhead box C1
GSTP1 glutathione S-transferase pi 1
IGF2 insulin-like growth factor 2
MIR182 microRNA 182
MIR223 microRNA 223
MIR503 microRNA 503
MLH1 mutL homolog 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NLK nemo-like kinase
NOTCH1 notch 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLK2 polo-like kinase 2
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PTEN phosphatase and tensin homolog
SACK1D scaffolding CK1 anchoring protein D
TAL1 T-cell acute lymphocytic leukemia 1
TGFB1 transforming growth factor, beta 1
TGIF1 TGFB-induced factor homeobox 1
TP53 tumor protein p53
YAP1 Yes-associated protein 1