felodipine-5294 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the felodipine-5294 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACTN1 actinin, alpha 1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ARHGAP33 Rho GTPase activating protein 33
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARMC4 armadillo repeat containing 4
ATF3 activating transcription factor 3
BBS9 Bardet-Biedl syndrome 9
CABIN1 calcineurin binding protein 1
CCNT2 cyclin T2
CD44 CD44 molecule (Indian blood group)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIC capicua transcriptional repressor
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CUL9 cullin 9
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DMC1 DNA meiotic recombinase 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP8 dual specificity phosphatase 8
EFNA1 ephrin-A1
EGR1 early growth response 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXO22 F-box protein 22
FCHO1 FCH domain only 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR87 G protein-coupled receptor 87
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H3B histone cluster 1, H3b
HMOX1 heme oxygenase 1
IER2 immediate early response 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KITLG KIT ligand
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLHL25 kelch-like family member 25
KRT17 keratin 17, type I
LAMP1 lysosomal-associated membrane protein 1
LIF leukemia inhibitory factor
LRP6 low density lipoprotein receptor-related protein 6
LRRC20 leucine rich repeat containing 20
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MST1 macrophage stimulating 1
NF1 neurofibromin 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
OASL 2'-5'-oligoadenylate synthetase-like
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PHC1 polyhomeotic homolog 1 (Drosophila)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIAS4 protein inhibitor of activated STAT, 4
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRLR prolactin receptor
PTRF polymerase I and transcript release factor
RANBP1 RAN binding protein 1
RCAN1 regulator of calcineurin 1
REC8 REC8 meiotic recombination protein
REEP1 receptor accessory protein 1
RNF19B ring finger protein 19B
RNF2 ring finger protein 2
RPL10 ribosomal protein L10
RPL35A ribosomal protein L35a
SCHIP1 schwannomin interacting protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SETD8 SET domain containing (lysine methyltransferase) 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SORBS3 sorbin and SH3 domain containing 3
SOS2 son of sevenless homolog 2 (Drosophila)
STARD5 StAR-related lipid transfer (START) domain containing 5
STON1 stonin 1
TAOK1 TAO kinase 1
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSPAN31 tetraspanin 31
ULBP2 UL16 binding protein 2
VEGFA vascular endothelial growth factor A
WDR62 WD repeat domain 62
WIZ widely interspaced zinc finger motifs
ZBTB48 zinc finger and BTB domain containing 48
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACTN4 actinin, alpha 4
ADCY3 adenylate cyclase 3
AKTIP AKT interacting protein
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BBS10 Bardet-Biedl syndrome 10
BCAS4 breast carcinoma amplified sequence 4
C14ORF132 chromosome 14 open reading frame 132
C16ORF59 chromosome 16 open reading frame 59
C1ORF115 chromosome 1 open reading frame 115
CENPC centromere protein C
CHN1 chimerin 1
COL9A2 collagen, type IX, alpha 2
CUEDC1 CUE domain containing 1
DNA2 DNA replication helicase/nuclease 2
DNM1 dynamin 1
EFHD1 EF-hand domain family, member D1
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
FAM169A family with sequence similarity 169, member A
FBXO3 F-box protein 3
FBXO46 F-box protein 46
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GMPPA GDP-mannose pyrophosphorylase A
GNPDA1 glucosamine-6-phosphate deaminase 1
H2AFJ H2A histone family, member J
HIST1H2AJ histone cluster 1, H2aj
HOXC6 homeobox C6
IGFLR1 IGF-like family receptor 1
IP6K1 inositol hexakisphosphate kinase 1
JRKL JRK-like
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LINC00115 long intergenic non-protein coding RNA 115
LMCD1 LIM and cysteine-rich domains 1
LMNB1 lamin B1
LYPD1 LY6/PLAUR domain containing 1
LYPD3 LY6/PLAUR domain containing 3
MAP9 microtubule-associated protein 9
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAPKBP1 mitogen-activated protein kinase binding protein 1
METTL2B methyltransferase like 2B
MICU1 mitochondrial calcium uptake 1
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL52 mitochondrial ribosomal protein L52
MSMO1 methylsterol monooxygenase 1
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NEO1 neogenin 1
NHEJ1 nonhomologous end-joining factor 1
NPY1R neuropeptide Y receptor Y1
NT5C 5', 3'-nucleotidase, cytosolic
NXN nucleoredoxin
OCEL1 occludin/ELL domain containing 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAQR3 progestin and adipoQ receptor family member III
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PRICKLE3 prickle homolog 3 (Drosophila)
PTER phosphotriesterase related
PTK6 protein tyrosine kinase 6
RBM15B RNA binding motif protein 15B
RBM41 RNA binding motif protein 41
RBM42 RNA binding motif protein 42
RCOR3 REST corepressor 3
RHOBTB1 Rho-related BTB domain containing 1
RINT1 RAD50 interactor 1
RNF123 ring finger protein 123
RUFY2 RUN and FYVE domain containing 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SHARPIN SHANK-associated RH domain interactor
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOX3 SRY (sex determining region Y)-box 3
TEFM transcription elongation factor, mitochondrial
TESK2 testis-specific kinase 2
THEM6 thioesterase superfamily member 6
TIMP2 TIMP metallopeptidase inhibitor 2
TLN1 talin 1
TMEM38B transmembrane protein 38B
TMEM39B transmembrane protein 39B
TRAF5 TNF receptor-associated factor 5
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSPYL5 TSPY-like 5
WLS wntless Wnt ligand secretion mediator
ZC3H3 zinc finger CCCH-type containing 3
ZNF329 zinc finger protein 329
ZNF813 zinc finger protein 813