femur Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The bone that extends from the pelvis to the knee, being the longest and largest bone in the body; its head articulates with the acetabulum of the hip bone, and distally, the femur, along with the patella and tibia, forms the knee joint. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001284)
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Genes

346 proteins co-occuring with the tissue femur in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
BGLAP bone gamma-carboxyglutamate (gla) protein 3.11307
PTH parathyroid hormone 2.73928
ALPL alkaline phosphatase, liver/bone/kidney 2.63878
ALPPL2 alkaline phosphatase, placental-like 2 2.63345
ALPP alkaline phosphatase, placental 2.63212
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.96884
BMP2 bone morphogenetic protein 2 1.93207
IGF1 insulin-like growth factor 1 (somatomedin C) 1.92007
ACPP acid phosphatase, prostate 1.83066
NOTCH1 notch 1 1.81481
SOST sclerostin 1.78084
RUNX2 runt-related transcription factor 2 1.70545
MGAM maltase-glucoamylase 1.66007
CALCA calcitonin-related polypeptide alpha 1.55309
AMIGO2 adhesion molecule with Ig-like domain 2 1.54971
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.5367
COL1A1 collagen, type I, alpha 1 1.49067
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.4589
SPP1 secreted phosphoprotein 1 1.44265
SP7 Sp7 transcription factor 1.41122
COL1A2 collagen, type I, alpha 2 1.39881
CTSK cathepsin K 1.35222
PTHLH parathyroid hormone-like hormone 1.28861
BMP7 bone morphogenetic protein 7 1.28681
LRP5 low density lipoprotein receptor-related protein 5 1.28143
CSN1S1 casein alpha s1 1.28053
ESR1 estrogen receptor 1 1.18024
LEP leptin 1.17846
MSLNL mesothelin-like 1.16781
ALB albumin 1.15096
HYLS1 hydrolethalus syndrome 1 1.14653
SHBG sex hormone-binding globulin 1.14564
ACAN aggrecan 1.13634
A1BG alpha-1-B glycoprotein 1.08148
IGFBP3 insulin-like growth factor binding protein 3 1.06956
COL2A1 collagen, type II, alpha 1 1.05457
INS insulin 1.012
CD34 CD34 molecule 0.991509
CRP C-reactive protein, pentraxin-related 0.990204
HHAT hedgehog acyltransferase 0.987597
FGF23 fibroblast growth factor 23 0.968955
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.954703
FGFR3 fibroblast growth factor receptor 3 0.954703
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.940495
TGFB1 transforming growth factor, beta 1 0.925051
VEGFA vascular endothelial growth factor A 0.904978
IBSP integrin-binding sialoprotein 0.895195
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit 0.892648
MMP13 matrix metallopeptidase 13 0.866842
BMP4 bone morphogenetic protein 4 0.847065
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.828197
IL6 interleukin 6 0.825686
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.823594
PHEX phosphate regulating endopeptidase homolog, X-linked 0.806465
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.801042
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 0.800626
TSPO translocator protein (18kDa) 0.794792
ZNF384 zinc finger protein 384 0.78938
ALAD aminolevulinate dehydratase 0.776494
SHOX short stature homeobox 0.773589
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.772759
NELL1 NEL-like 1 (chicken) 0.766539
FGF2 fibroblast growth factor 2 (basic) 0.760742
LCORL ligand dependent nuclear receptor corepressor-like 0.752884
SOX9 SRY (sex determining region Y)-box 9 0.737206
IHH indian hedgehog 0.722809
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 0.722398
BHLHB9 basic helix-loop-helix domain containing, class B, 9 0.716241
TNF tumor necrosis factor 0.712549
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.70968
LCTL lactase-like 0.703127
SLC51A solute carrier family 51, alpha subunit 0.698625
ZNF410 zinc finger protein 410 0.684327
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.681064
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 0.675765
FOS FBJ murine osteosarcoma viral oncogene homolog 0.671692
MEPE matrix extracellular phosphoglycoprotein 0.665995
NCOA1 nuclear receptor coactivator 1 0.661523
ESR2 estrogen receptor 2 (ER beta) 0.650154
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.650154
IGFBP5 insulin-like growth factor binding protein 5 0.650154
TBCA tubulin folding cofactor A 0.645695
GH1 growth hormone 1 0.643669
PPARG peroxisome proliferator-activated receptor gamma 0.640023
CNOT8 CCR4-NOT transcription complex, subunit 8 0.639619
TF transferrin 0.637999
IL1B interleukin 1, beta 0.63274
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.631123
AFP alpha-fetoprotein 0.62991
BMP3 bone morphogenetic protein 3 0.623043
RTP3 receptor (chemosensory) transporter protein 3 0.617796
TRUB1 TruB pseudouridine (psi) synthase family member 1 0.616183
ZNF28 zinc finger protein 28 0.61578
MMP9 matrix metallopeptidase 9 0.613361
TRPV5 transient receptor potential cation channel, subfamily V, member 5 0.610541
LAX1 lymphocyte transmembrane adaptor 1 0.603295
MRPL49 mitochondrial ribosomal protein L49 0.597263
GDF10 growth differentiation factor 10 0.593247
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.588431
HOXD11 homeobox D11 0.586427
F2 coagulation factor II (thrombin) 0.585224
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.575216
HLA-DMA major histocompatibility complex, class II, DM alpha 0.572018
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 0.570021
SPTA1 spectrin, alpha, erythrocytic 1 0.569622
AR androgen receptor 0.568025
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) 0.56603
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.564833
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.56284
SRCIN1 SRC kinase signaling inhibitor 1 0.559652
HBA2 hemoglobin, alpha 2 0.556865
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.554478
GCM2 glial cells missing homolog 2 (Drosophila) 0.554478
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.538604
NF1 neurofibromin 1 0.537416
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 0.533856
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.531879
PRRC2A proline-rich coiled-coil 2A 0.531484
PRSS50 protease, serine, 50 0.531484
GOLGB1 golgin B1 0.531484
MGP matrix Gla protein 0.528323
INTS5 integrator complex subunit 5 0.525955
CRTAP cartilage associated protein 0.523982
THY1 Thy-1 cell surface antigen 0.516497
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.514924
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.514924
PAPPA2 pappalysin 2 0.51453
CASR calcium-sensing receptor 0.512564
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.510206
BGN biglycan 0.508242
DSC3 desmocollin 3 0.506672
CALCR calcitonin receptor 0.498048
TNNC1 troponin C type 1 (slow) 0.495701
SEC23IP SEC23 interacting protein 0.493745
CD44 CD44 molecule (Indian blood group) 0.493745
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 0.492572
COMP cartilage oligomeric matrix protein 0.489838
DAND5 DAN domain family member 5, BMP antagonist 0.485156
OSCAR osteoclast associated, immunoglobulin-like receptor 0.484766
F8 coagulation factor VIII, procoagulant component 0.482428
MMP3 matrix metallopeptidase 3 0.482038
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.480091
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 0.477367
HBA1 hemoglobin, alpha 1 0.471151
CXCL12 chemokine (C-X-C motif) ligand 12 0.471151
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.466111
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.464561
CTPS1 CTP synthase 1 0.463013
GLB1 galactosidase, beta 1 0.461078
FBXO42 F-box protein 42 0.461078
PPT1 palmitoyl-protein thioesterase 1 0.456442
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.454898
FN1 fibronectin 1 0.454126
MATN3 matrilin 3 0.451428
PFN2 profilin 2 0.451042
DEFB105B defensin, beta 105B 0.450271
SOD2 superoxide dismutase 2, mitochondrial 0.446807
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.443731
PGRMC1 progesterone receptor membrane component 1 0.441426
C7ORF49 chromosome 7 open reading frame 49 0.440274
GPX1 glutathione peroxidase 1 0.437972
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.434906
HGD homogentisate 1,2-dioxygenase 0.433757
MMP28 matrix metallopeptidase 28 0.430695
C1ORF174 chromosome 1 open reading frame 174 0.430312
GPX5 glutathione peroxidase 5 0.429165
ASRGL1 asparaginase like 1 0.428018
COL10A1 collagen, type X, alpha 1 0.427636
GPX4 glutathione peroxidase 4 0.425344
S100G S100 calcium binding protein G 0.424581
TP53 tumor protein p53 0.420766
CAT catalase 0.420004
F3 coagulation factor III (thromboplastin, tissue factor) 0.419623
TGFB3 transforming growth factor, beta 3 0.416957
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 0.416195
ZNF71 zinc finger protein 71 0.415814
MMP2 matrix metallopeptidase 2 0.414673
PCNA proliferating cell nuclear antigen 0.410111
NOG noggin 0.409351
GC group-specific component (vitamin D binding protein) 0.407453
TRPV6 transient receptor potential cation channel, subfamily V, member 6 0.406315
TWF1 twinfilin actin binding protein 1 0.404039
HIST1H4J histone cluster 1, H4j 0.402144
HIST1H4I histone cluster 1, H4i 0.402144
HIST1H4H histone cluster 1, H4h 0.402144
HIST1H4D histone cluster 1, H4d 0.402144
HIST1H4E histone cluster 1, H4e 0.402144
HIST2H4A histone cluster 2, H4a 0.402144
HIST2H4B histone cluster 2, H4b 0.402144
HIST1H4C histone cluster 1, H4c 0.402144
HIST1H4B histone cluster 1, H4b 0.402144
HIST1H4A histone cluster 1, H4a 0.402144
HIST1H4K histone cluster 1, H4k 0.402144
HIST1H4F histone cluster 1, H4f 0.402144
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 0.401386
NOVA2 neuro-oncological ventral antigen 2 0.401007
HIST1H4L histone cluster 1, H4l 0.400628
HIST4H4 histone cluster 4, H4 0.400628
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.399871
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 0.398357
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.396844
EXT2 exostosin glycosyltransferase 2 0.394953
KIF17 kinesin family member 17 0.394953
PTH1R parathyroid hormone 1 receptor 0.394576
MT1A metallothionein 1A 0.387781
DCN decorin 0.38665
CA10 carbonic anhydrase X 0.38326
BRI3BP BRI3 binding protein 0.382884
AXIN2 axin 2 0.381379
FTH1 ferritin, heavy polypeptide 1 0.380251
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.379123
IGHA1 immunoglobulin heavy constant alpha 1 0.379123
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 0.376494
ANKRD37 ankyrin repeat domain 37 0.376119
TAC1 tachykinin, precursor 1 0.375743
ZNF461 zinc finger protein 461 0.374993
PRRX1 paired related homeobox 1 0.371619
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.361901
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 0.360782
FAM3C family with sequence similarity 3, member C 0.360409
CATSPER4 cation channel, sperm associated 4 0.359664
SNX10 sorting nexin 10 0.359292
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 0.358546
SIGLEC15 sialic acid binding Ig-like lectin 15 0.358546
TIMP1 TIMP metallopeptidase inhibitor 1 0.356314
SHOX2 short stature homeobox 2 0.355942
GREM1 gremlin 1, DAN family BMP antagonist 0.351856
FAM120A family with sequence similarity 120A 0.350372
RABGAP1 RAB GTPase activating protein 1 0.346298
HPS6 Hermansky-Pudlak syndrome 6 0.344449
BMP5 bone morphogenetic protein 5 0.344079
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.342233
COL9A1 collagen, type IX, alpha 1 0.341495
ESM1 endothelial cell-specific molecule 1 0.341126
UBE2K ubiquitin-conjugating enzyme E2K 0.338545
GPR22 G protein-coupled receptor 22 0.338177
EXT1 exostosin glycosyltransferase 1 0.334498
CKAP2 cytoskeleton associated protein 2 0.333396
HIP1R huntingtin interacting protein 1 related 0.328628
FABP4 fatty acid binding protein 4, adipocyte 0.327164
DCPS decapping enzyme, scavenger 0.327164
FTL ferritin, light polypeptide 0.32497
SATB2 SATB homeobox 2 0.32132
WNT3A wingless-type MMTV integration site family, member 3A 0.32132
OMD osteomodulin 0.320956
GATA4 GATA binding protein 4 0.320956
IL1A interleukin 1, alpha 0.319863
FLNB filamin B, beta 0.318042
LRP6 low density lipoprotein receptor-related protein 6 0.317315
POMC proopiomelanocortin 0.315135
GHRH growth hormone releasing hormone 0.307528
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.306444
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.303919
BAMBI BMP and activin membrane-bound inhibitor 0.303919
MARS2 methionyl-tRNA synthetase 2, mitochondrial 0.30032
FAF2 Fas associated factor family member 2 0.298524
TCF4 transcription factor 4 0.298165
LEMD3 LEM domain containing 3 0.291365
CLDN18 claudin 18 0.288514
GPANK1 G patch domain and ankyrin repeats 1 0.285316
MPO myeloperoxidase 0.284607
LXN latexin 0.283899
AKAP8L A kinase (PRKA) anchor protein 8-like 0.278603
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.2779
TES testin LIM domain protein 0.277549
ETV3 ets variant 3 0.276846
MIA3 melanoma inhibitory activity family, member 3 0.274045
HMGB1 high mobility group box 1 0.273696
COG5 component of oligomeric golgi complex 5 0.273346
CLCN7 chloride channel, voltage-sensitive 7 0.2723
GLS2 glutaminase 2 (liver, mitochondrial) 0.2723
CANT1 calcium activated nucleotidase 1 0.270214
BMP2K BMP2 inducible kinase 0.267791
B2M beta-2-microglobulin 0.267102
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 0.266757
ANKLE1 ankyrin repeat and LEM domain containing 1 0.265038
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.262986
GJA1 gap junction protein, alpha 1, 43kDa 0.261624
UST uronyl-2-sulfotransferase 0.260267
CXCR4 chemokine (C-X-C motif) receptor 4 0.260267
ALK anaplastic lymphoma receptor tyrosine kinase 0.259929
TPR translocated promoter region, nuclear basket protein 0.259591
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.259591
TOE1 target of EGR1, member 1 (nuclear) 0.257572
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.256234
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.251279
BCAP29 B-cell receptor-associated protein 29 0.250627
ST7 suppression of tumorigenicity 7 0.250301
LDLR low density lipoprotein receptor 0.249653
GREM2 gremlin 2, DAN family BMP antagonist 0.249653
ACP5 acid phosphatase 5, tartrate resistant 0.247719
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.247719
MTBP MDM2 binding protein 0.247079
DLX5 distal-less homeobox 5 0.247079
FAT1 FAT atypical cadherin 1 0.244545
ELOVL2 ELOVL fatty acid elongase 2 0.242983
LEPR leptin receptor 0.242672
SP9 Sp9 transcription factor 0.242054
WISP3 WNT1 inducible signaling pathway protein 3 0.241438
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.24052
CYCS cytochrome c, somatic 0.24052
DMRTA1 DMRT-like family A1 0.240216
MPL MPL proto-oncogene, thrombopoietin receptor 0.238406
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.236627
CTGF connective tissue growth factor 0.23459
PTPRC protein tyrosine phosphatase, receptor type, C 0.23459
NCDN neurochondrin 0.234016
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.232039
IARS isoleucyl-tRNA synthetase 0.231482
THEM4 thioesterase superfamily member 4 0.231206
AMELY amelogenin, Y-linked 0.231206
ENO2 enolase 2 (gamma, neuronal) 0.230931
MTX3 metaxin 3 0.230656
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.229032
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 0.229032
SBDS Shwachman-Bodian-Diamond syndrome 0.228497
MMP1 matrix metallopeptidase 1 0.227707
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.227707
SCUBE3 signal peptide, CUB domain, EGF-like 3 0.227186
C6ORF25 chromosome 6 open reading frame 25 0.226667
AMELX amelogenin, X-linked 0.225144
ANOS1 anosmin 1 0.224398
GHR growth hormone receptor 0.221989
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.221755
ZDHHC17 zinc finger, DHHC-type containing 17 0.221521
PTGES prostaglandin E synthase 0.221521
PAPOLB poly(A) polymerase beta (testis specific) 0.220831
KCTD12 potassium channel tetramerization domain containing 12 0.220604
FGF4 fibroblast growth factor 4 0.219485
FGFR2 fibroblast growth factor receptor 2 0.219485
HN1 hematological and neurological expressed 1 0.217762
RXFP2 relaxin/insulin-like family peptide receptor 2 0.217762
BMP1 bone morphogenetic protein 1 0.21673
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.216528
NOTO notochord homeobox 0.216528
CD68 CD68 molecule 0.216325
NGF nerve growth factor (beta polypeptide) 0.214954
TNRC6A trinucleotide repeat containing 6A 0.214765
NAV2 neuron navigator 2 0.214576
EWSR1 EWS RNA-binding protein 1 0.214202
PSG1 pregnancy specific beta-1-glycoprotein 1 0.214017
ENOX2 ecto-NOX disulfide-thiol exchanger 2 0.213471
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.213112
MAEA macrophage erythroblast attacher 0.212936
EFNB2 ephrin-B2 0.212761
CD79A CD79a molecule, immunoglobulin-associated alpha 0.212761