fenbufen-4279 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the fenbufen-4279 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACAN aggrecan
ACO2 aconitase 2, mitochondrial
ACOT11 acyl-CoA thioesterase 11
ADGRB2 adhesion G protein-coupled receptor B2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP11A ATPase, class VI, type 11A
BBC3 BCL2 binding component 3
C19ORF73 chromosome 19 open reading frame 73
C5ORF45 chromosome 5 open reading frame 45
CASZ1 castor zinc finger 1
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD58 CD58 molecule
CDH19 cadherin 19, type 2
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CLDN10 claudin 10
CLTA clathrin, light chain A
CLTCL1 clathrin, heavy chain-like 1
COBLL1 cordon-bleu WH2 repeat protein-like 1
CSN3 casein kappa
DAO D-amino-acid oxidase
DEFA5 defensin, alpha 5, Paneth cell-specific
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EDN1 endothelin 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERN1 endoplasmic reticulum to nucleus signaling 1
FAM49B family with sequence similarity 49, member B
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GK glycerol kinase
GPNMB glycoprotein (transmembrane) nmb
GPR17 G protein-coupled receptor 17
GRB7 growth factor receptor-bound protein 7
GVINP1 GTPase, very large interferon inducible pseudogene 1
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HIST1H2AB histone cluster 1, H2ab
HMGB3P1 high mobility group box 3 pseudogene 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ING1 inhibitor of growth family, member 1
ING4 inhibitor of growth family, member 4
IRF4 interferon regulatory factor 4
IRX4 iroquois homeobox 4
ITGA7 integrin, alpha 7
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KDR kinase insert domain receptor
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
LAT2 linker for activation of T cells family, member 2
LOC100294391 uncharacterized LOC100294391
MAPK8 mitogen-activated protein kinase 8
MSX2 msh homeobox 2
MTA2 metastasis associated 1 family, member 2
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
N4BP2L1 NEDD4 binding protein 2-like 1
NCF4 neutrophil cytosolic factor 4, 40kDa
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELL2 NEL-like 2 (chicken)
OVOL1 ovo-like zinc finger 1
PCDHB3 protocadherin beta 3
PCDHGA8 protocadherin gamma subfamily A, 8
PDLIM5 PDZ and LIM domain 5
PKP3 plakophilin 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK3 polo-like kinase 3
PML promyelocytic leukemia
POPDC2 popeye domain containing 2
PPP1R37 protein phosphatase 1, regulatory subunit 37
PQLC2 PQ loop repeat containing 2
PRSS22 protease, serine, 22
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB6B RAB6B, member RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RGS14 regulator of G-protein signaling 14
RHOT2 ras homolog family member T2
RIBC2 RIB43A domain with coiled-coils 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNDC3A RUN domain containing 3A
RXRB retinoid X receptor, beta
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SH3GL3 SH3-domain GRB2-like 3
SLC22A14 solute carrier family 22, member 14
SMAD6 SMAD family member 6
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SOCS3 suppressor of cytokine signaling 3
SRRT serrate, RNA effector molecule
STRA6 stimulated by retinoic acid 6
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
UPK3B uroplakin 3B
ZBTB7A zinc finger and BTB domain containing 7A
ZSCAN18 zinc finger and SCAN domain containing 18
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACSS3 acyl-CoA synthetase short-chain family member 3
AGO3 argonaute RISC catalytic component 3
AK5 adenylate kinase 5
ALPK1 alpha-kinase 1
ANKH ANKH inorganic pyrophosphate transport regulator
ASAP1-IT1 ASAP1 intronic transcript 1
ATG10 autophagy related 10
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNT1 cyclin T1
CD68 CD68 molecule
CDH7 cadherin 7, type 2
CEP295 centrosomal protein 295kDa
CHM choroideremia (Rab escort protein 1)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CREB5 cAMP responsive element binding protein 5
DCBLD2 discoidin, CUB and LCCL domain containing 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR2 early growth response 2
EHF ets homologous factor
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FAM184A family with sequence similarity 184, member A
FBXO22 F-box protein 22
FGF23 fibroblast growth factor 23
FOXN2 forkhead box N2
GLDC glycine dehydrogenase (decarboxylating)
GLS2 glutaminase 2 (liver, mitochondrial)
HELLS helicase, lymphoid-specific
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H2AG histone cluster 1, H2ag
HIST1H2BJ histone cluster 1, H2bj
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC5 homeobox C5
IREB2 iron-responsive element binding protein 2
ITK IL2-inducible T-cell kinase
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA0754 KIAA0754
KIAA1107 KIAA1107
KIRREL kin of IRRE like (Drosophila)
LIPG lipase, endothelial
LMNB1 lamin B1
LOC100127972 uncharacterized LOC100127972
LRP2 low density lipoprotein receptor-related protein 2
LYRM9 LYR motif containing 9
MED31 mediator complex subunit 31
MGC12488
MIS18BP1 MIS18 binding protein 1
MMP3 matrix metallopeptidase 3
MUC3B mucin 3B, cell surface associated
NABP1 nucleic acid binding protein 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NR1D2 nuclear receptor subfamily 1, group D, member 2
PCDHA9 protocadherin alpha 9
PDE12 phosphodiesterase 12
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
POGLUT1 protein O-glucosyltransferase 1
POLL polymerase (DNA directed), lambda
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PTER phosphotriesterase related
RNF126P1 ring finger protein 126 pseudogene 1
RPA4 replication protein A4, 30kDa
SCG5 secretogranin V
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SKI SKI proto-oncogene
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMAD5 SMAD family member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPIN1 spindlin 1
SREK1IP1 SREK1-interacting protein 1
STX17 syntaxin 17
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIGD6 tigger transposable element derived 6
TM6SF1 transmembrane 6 superfamily member 1
TMEM260 transmembrane protein 260
UGCG UDP-glucose ceramide glucosyltransferase
USP20 ubiquitin specific peptidase 20
USP36 ubiquitin specific peptidase 36
WWC2 WW and C2 domain containing 2
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
YOD1 YOD1 deubiquitinase
ZFHX2 zinc finger homeobox 2
ZNF124 zinc finger protein 124
ZNF442 zinc finger protein 442
ZNF675 zinc finger protein 675
ZNF702P zinc finger protein 702, pseudogene
ZNF711 zinc finger protein 711
ZNF770 zinc finger protein 770
Funding