fendiline-3190 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fendiline-3190 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACE2 angiotensin I converting enzyme 2
AKAP10 A kinase (PRKA) anchor protein 10
AKR1C4 aldo-keto reductase family 1, member C4
APC adenomatous polyposis coli
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
C14ORF105 chromosome 14 open reading frame 105
C17ORF53 chromosome 17 open reading frame 53
C6 complement component 6
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CGA glycoprotein hormones, alpha polypeptide
CSHL1 chorionic somatomammotropin hormone-like 1
CTNNA2 catenin (cadherin-associated protein), alpha 2
DCTN1 dynactin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DENND1C DENN/MADD domain containing 1C
DEPDC5 DEP domain containing 5
DLX2 distal-less homeobox 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DYM dymeclin
ECE1 endothelin converting enzyme 1
EGR1 early growth response 1
EGR2 early growth response 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXH1 forkhead box H1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPC1 glypican 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
HBEGF heparin-binding EGF-like growth factor
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1T histone cluster 1, H1t
HIST1H2BJ histone cluster 1, H2bj
HIST1H3B histone cluster 1, H3b
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INHBE inhibin, beta E
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT9 keratin 9, type I
LIF leukemia inhibitory factor
LPIN1 lipin 1
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NCKIPSD NCK interacting protein with SH3 domain
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
OASL 2'-5'-oligoadenylate synthetase-like
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSGIN1 oxidative stress induced growth inhibitor 1
OSMR oncostatin M receptor
PDE4DIP phosphodiesterase 4D interacting protein
PER1 period circadian clock 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSD4 pleckstrin and Sec7 domain containing 4
RGS14 regulator of G-protein signaling 14
RND1 Rho family GTPase 1
RUNDC3A RUN domain containing 3A
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC16A4 solute carrier family 16, member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC1A structural maintenance of chromosomes 1A
SOX9 SRY (sex determining region Y)-box 9
SPAG8 sperm associated antigen 8
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPINK1 serine peptidase inhibitor, Kazal type 1
SYNPO synaptopodin
TLR2 toll-like receptor 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRD T cell receptor delta locus
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACBD4 acyl-CoA binding domain containing 4
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANP32A-IT1 ANP32A intronic transcript 1
ANXA2P3 annexin A2 pseudogene 3
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ART1 ADP-ribosyltransferase 1
ATAD3A ATPase family, AAA domain containing 3A
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
C22ORF46 chromosome 22 open reading frame 46
C2ORF27A chromosome 2 open reading frame 27A
C8ORF60 chromosome 8 open reading frame 60
C9ORF9 chromosome 9 open reading frame 9
CAMKV CaM kinase-like vesicle-associated
CBX8 chromobox homolog 8
CCDC132 coiled-coil domain containing 132
CCDC25 coiled-coil domain containing 25
CD82 CD82 molecule
CEP97 centrosomal protein 97kDa
CHST10 carbohydrate sulfotransferase 10
CLIP4 CAP-GLY domain containing linker protein family, member 4
CPPED1 calcineurin-like phosphoesterase domain containing 1
CSF1R colony stimulating factor 1 receptor
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSC cathepsin C
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCAF13 DDB1 and CUL4 associated factor 13
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ELP6 elongator acetyltransferase complex subunit 6
EMID1 EMI domain containing 1
ERN2 endoplasmic reticulum to nucleus signaling 2
EVA1B eva-1 homolog B (C. elegans)
F8 coagulation factor VIII, procoagulant component
FANCE Fanconi anemia, complementation group E
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FRS2 fibroblast growth factor receptor substrate 2
GAMT guanidinoacetate N-methyltransferase
GMPR guanosine monophosphate reductase
GPR19 G protein-coupled receptor 19
GPX1 glutathione peroxidase 1
GSTM2 glutathione S-transferase mu 2 (muscle)
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC8 homeobox C8
IDI2-AS1 IDI2 antisense RNA 1
IL4R interleukin 4 receptor
INCENP inner centromere protein antigens 135/155kDa
ITGA10 integrin, alpha 10
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KDM8 lysine (K)-specific demethylase 8
KIF13A kinesin family member 13A
KRT83 keratin 83, type II
LATS1 large tumor suppressor kinase 1
LDHB lactate dehydrogenase B
LOC730101 uncharacterized LOC730101
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYZ lysozyme
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MATK megakaryocyte-associated tyrosine kinase
MUC3A mucin 3A, cell surface associated
PADI1 peptidyl arginine deiminase, type I
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PSAT1 phosphoserine aminotransferase 1
PTTG3P pituitary tumor-transforming 3, pseudogene
RNF122 ring finger protein 122
ROM1 retinal outer segment membrane protein 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SH2D4A SH2 domain containing 4A
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SREK1IP1 SREK1-interacting protein 1
SRGN serglycin
TDRD1 tudor domain containing 1
THRAP3 thyroid hormone receptor associated protein 3
TMEM121 transmembrane protein 121
TPST1 tyrosylprotein sulfotransferase 1
TSC22D4 TSC22 domain family, member 4
UPK3B uroplakin 3B
USP19 ubiquitin specific peptidase 19
XYLT2 xylosyltransferase II
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF227 zinc finger protein 227
ZNF34 zinc finger protein 34
ZNF510 zinc finger protein 510
ZNF573 zinc finger protein 573
ZNF770 zinc finger protein 770
ZSCAN26 zinc finger and SCAN domain containing 26