fenspiride-2106 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fenspiride-2106 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADAP1 ArfGAP with dual PH domains 1
ADGRE2 adhesion G protein-coupled receptor E2
ADRBK1 adrenergic, beta, receptor kinase 1
ARC activity-regulated cytoskeleton-associated protein
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C10ORF10 chromosome 10 open reading frame 10
C11ORF63 chromosome 11 open reading frame 63
C1ORF95 chromosome 1 open reading frame 95
CCDC71 coiled-coil domain containing 71
CDC25C cell division cycle 25C
CFAP45 cilia and flagella associated protein 45
CIDEC cell death-inducing DFFA-like effector c
CLCN5 chloride channel, voltage-sensitive 5
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CRYAB crystallin, alpha B
CRYGD crystallin, gamma D
CTIF CBP80/20-dependent translation initiation factor
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
ESRRA estrogen-related receptor alpha
ETV7 ets variant 7
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FASTKD2 FAST kinase domains 2
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPR3 G protein-coupled receptor 3
HNF1B HNF1 homeobox B
HOXA4 homeobox A4
IFITM1 interferon induced transmembrane protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1RN interleukin 1 receptor antagonist
IL2RG interleukin 2 receptor, gamma
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MED16 mediator complex subunit 16
MKL1 megakaryoblastic leukemia (translocation) 1
MMP25 matrix metallopeptidase 25
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NAAA N-acylethanolamine acid amidase
NDRG2 NDRG family member 2
NEK11 NIMA-related kinase 11
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP160 nucleoporin 160kDa
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAM peptidylglycine alpha-amidating monooxygenase
PCDH9 protocadherin 9
PDE10A phosphodiesterase 10A
PEX5 peroxisomal biogenesis factor 5
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKP3 plakophilin 3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRMT2 protein arginine methyltransferase 2
PTCRA pre T-cell antigen receptor alpha
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPRU protein tyrosine phosphatase, receptor type, U
RAB27B RAB27B, member RAS oncogene family
RNF122 ring finger protein 122
RNF43 ring finger protein 43
SASH3 SAM and SH3 domain containing 3
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SIGLEC15 sialic acid binding Ig-like lectin 15
SIRT4 sirtuin 4
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNX11 sorting nexin 11
SOX13 SRY (sex determining region Y)-box 13
SPRED2 sprouty-related, EVH1 domain containing 2
SSBP3 single stranded DNA binding protein 3
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STXBP6 syntaxin binding protein 6 (amisyn)
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBC1D13 TBC1 domain family, member 13
TBKBP1 TBK1 binding protein 1
TBX6 T-box 6
TEX40 testis expressed 40
TM9SF4 transmembrane 9 superfamily protein member 4
TMEM63A transmembrane protein 63A
TMPRSS15 transmembrane protease, serine 15
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
USB1 U6 snRNA biogenesis 1
USP34 ubiquitin specific peptidase 34
VGF VGF nerve growth factor inducible
XDH xanthine dehydrogenase
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF442 zinc finger protein 442
ZNF609 zinc finger protein 609
ZNF710 zinc finger protein 710
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACYP2 acylphosphatase 2, muscle type
ADM adrenomedullin
ANOS1 anosmin 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARMC6 armadillo repeat containing 6
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BCL2L2 BCL2-like 2
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C9ORF40 chromosome 9 open reading frame 40
CCL20 chemokine (C-C motif) ligand 20
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDK3 cyclin-dependent kinase 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC2B C-type lectin domain family 2, member B
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CPNE1 copine I
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCL2 chemokine (C-X-C motif) ligand 2
DGKZ diacylglycerol kinase, zeta
DHRS2 dehydrogenase/reductase (SDR family) member 2
EPN3 epsin 3
EXOC3 exocyst complex component 3
FANCF Fanconi anemia, complementation group F
FBXL15 F-box and leucine-rich repeat protein 15
FBXL7 F-box and leucine-rich repeat protein 7
FBXO2 F-box protein 2
FBXO46 F-box protein 46
FKBP10 FK506 binding protein 10, 65 kDa
FOXC1 forkhead box C1
GLT8D2 glycosyltransferase 8 domain containing 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRAMD4 GRAM domain containing 4
HCG4 HLA complex group 4 (non-protein coding)
HINFP histone H4 transcription factor
HOXB13 homeobox B13
HP1BP3 heterochromatin protein 1, binding protein 3
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
JMJD4 jumonji domain containing 4
KCTD7 potassium channel tetramerization domain containing 7
KIAA0753 KIAA0753
KIAA0754 KIAA0754
KLHL3 kelch-like family member 3
KRT33A keratin 33A, type I
MAST3 microtubule associated serine/threonine kinase 3
MIS18BP1 MIS18 binding protein 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NCS1 neuronal calcium sensor 1
NPFFR1 neuropeptide FF receptor 1
NT5C 5', 3'-nucleotidase, cytosolic
NYNRIN NYN domain and retroviral integrase containing
OLFML3 olfactomedin-like 3
PLA2G15 phospholipase A2, group XV
PLAC8 placenta-specific 8
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCD1 phospholipase C, delta 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PMCH pro-melanin-concentrating hormone
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POMT2 protein-O-mannosyltransferase 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRR7 proline rich 7 (synaptic)
RAB20 RAB20, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC35E3 solute carrier family 35, member E3
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNTA1 syntrophin, alpha 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TH tyrosine hydroxylase
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TMEM120B transmembrane protein 120B
TMEM53 transmembrane protein 53
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TUBG2 tubulin, gamma 2
TXLNA taxilin alpha
UBQLN4 ubiquilin 4
UBXN6 UBX domain protein 6
WDR19 WD repeat domain 19
WDR33 WD repeat domain 33
WDR60 WD repeat domain 60
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XYLT2 xylosyltransferase II
ZFP36 ZFP36 ring finger protein
ZMAT5 zinc finger, matrin-type 5
ZNF124 zinc finger protein 124
ZNF215 zinc finger protein 215
ZNF34 zinc finger protein 34
ZNF671 zinc finger protein 671
ZNRD1-AS1 ZNRD1 antisense RNA 1
ZW10 zw10 kinetochore protein