fenspiride-2269 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fenspiride-2269 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADAM12 ADAM metallopeptidase domain 12
ADAM29 ADAM metallopeptidase domain 29
ADGRL3 adhesion G protein-coupled receptor L3
ADRBK1 adrenergic, beta, receptor kinase 1
AHNAK AHNAK nucleoprotein
ALLC allantoicase
ALOX15B arachidonate 15-lipoxygenase, type B
ARC activity-regulated cytoskeleton-associated protein
ARRB2 arrestin, beta 2
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BAAT bile acid CoA:amino acid N-acyltransferase
BLK BLK proto-oncogene, Src family tyrosine kinase
CADM3 cell adhesion molecule 3
CAPN9 calpain 9
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCL19 chemokine (C-C motif) ligand 19
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD86 CD86 molecule
CDK14 cyclin-dependent kinase 14
CDRT1 CMT1A duplicated region transcript 1
CETN1 centrin, EF-hand protein, 1
CLEC2B C-type lectin domain family 2, member B
CLEC3B C-type lectin domain family 3, member B
CLEC4A C-type lectin domain family 4, member A
CLTA clathrin, light chain A
CNOT2 CCR4-NOT transcription complex, subunit 2
CROCC ciliary rootlet coiled-coil, rootletin
CSF1R colony stimulating factor 1 receptor
ETV5 ets variant 5
EXOC7 exocyst complex component 7
FN1 fibronectin 1
FRMD8 FERM domain containing 8
FXYD5 FXYD domain containing ion transport regulator 5
GLS glutaminase
GP1BB glycoprotein Ib (platelet), beta polypeptide
GP5 glycoprotein V (platelet)
GPR137 G protein-coupled receptor 137
GPR15 G protein-coupled receptor 15
GSK3A glycogen synthase kinase 3 alpha
GZMK granzyme K (granzyme 3; tryptase II)
HCRP1 hepatocellular carcinoma-related HCRP1
HDAC6 histone deacetylase 6
HDAC7 histone deacetylase 7
HDC histidine decarboxylase
HIPK2 homeodomain interacting protein kinase 2
HOXB2 homeobox B2
HP haptoglobin
HRH4 histamine receptor H4
ICAM1 intercellular adhesion molecule 1
IDI2-AS1 IDI2 antisense RNA 1
IL1R1 interleukin 1 receptor, type I
ITGA8 integrin, alpha 8
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KRT75 keratin 75, type II
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIMK1 LIM domain kinase 1
LRRC15 leucine rich repeat containing 15
MAP1A microtubule-associated protein 1A
MARK4 MAP/microtubule affinity-regulating kinase 4
MIR622 microRNA 622
MXD4 MAX dimerization protein 4
MYO15B myosin XVB
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NAAA N-acylethanolamine acid amidase
NKX3-1 NK3 homeobox 1
NPR1 natriuretic peptide receptor 1
NRP2 neuropilin 2
NTF3 neurotrophin 3
OR12D3 olfactory receptor, family 12, subfamily D, member 3
PAPPA2 pappalysin 2
PAX9 paired box 9
PCDHB6 protocadherin beta 6
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLAC4 placenta-specific 4
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PRB1 proline-rich protein BstNI subfamily 1
PRDM14 PR domain containing 14
RNF2 ring finger protein 2
SAMD9 sterile alpha motif domain containing 9
SC5D sterol-C5-desaturase
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLIT1 slit homolog 1 (Drosophila)
SOAT2 sterol O-acyltransferase 2
SOX10 SRY (sex determining region Y)-box 10
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SREBF2 sterol regulatory element binding transcription factor 2
STAT2 signal transducer and activator of transcription 2, 113kDa
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TGM2 transglutaminase 2
TJAP1 tight junction associated protein 1 (peripheral)
TMEM254 transmembrane protein 254
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIM15 tripartite motif containing 15
ZNF3 zinc finger protein 3

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADGRE5 adhesion G protein-coupled receptor E5
AFAP1 actin filament associated protein 1
AMT aminomethyltransferase
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B9D2 B9 protein domain 2
BAHCC1 BAH domain and coiled-coil containing 1
BAHD1 bromo adjacent homology domain containing 1
C22ORF46 chromosome 22 open reading frame 46
C7ORF43 chromosome 7 open reading frame 43
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAPN15 calpain 15
CDK3 cyclin-dependent kinase 3
CDKL3 cyclin-dependent kinase-like 3
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CUZD1 CUB and zona pellucida-like domains 1
ERCC6 excision repair cross-complementation group 6
ERN1 endoplasmic reticulum to nucleus signaling 1
FAM212B family with sequence similarity 212, member B
FER fer (fps/fes related) tyrosine kinase
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GFI1 growth factor independent 1 transcription repressor
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HIST1H4A histone cluster 1, H4a
HP1BP3 heterochromatin protein 1, binding protein 3
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIAA0894 KIAA0894 protein
LAMA3 laminin, alpha 3
LARP6 La ribonucleoprotein domain family, member 6
LOC257152 uncharacterized LOC257152
LTBP2 latent transforming growth factor beta binding protein 2
LY6G6C lymphocyte antigen 6 complex, locus G6C
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MSI1 musashi RNA-binding protein 1
MTCP1 mature T-cell proliferation 1
NDE1 nudE neurodevelopment protein 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSMR oncostatin M receptor
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAIP2B poly(A) binding protein interacting protein 2B
PEX26 peroxisomal biogenesis factor 26
PGM1 phosphoglucomutase 1
PITX2 paired-like homeodomain 2
PLCD1 phospholipase C, delta 1
POMT2 protein-O-mannosyltransferase 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRODH proline dehydrogenase (oxidase) 1
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASL11B RAS-like, family 11, member B
RCAN3 RCAN family member 3
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RLN1 relaxin 1
RNF122 ring finger protein 122
RPAP2 RNA polymerase II associated protein 2
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SETD1A SET domain containing 1A
SKI SKI proto-oncogene
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A10 solute carrier family 38, member 10
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SMIM14 small integral membrane protein 14
SND1-IT1 SND1 intronic transcript 1
SP1 Sp1 transcription factor
SPRY2 sprouty homolog 2 (Drosophila)
STAB2 stabilin 2
STARD3 StAR-related lipid transfer (START) domain containing 3
STRA6 stimulated by retinoic acid 6
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TAOK1 TAO kinase 1
TBC1D2 TBC1 domain family, member 2
TMEM53 transmembrane protein 53
TRIM25 tripartite motif containing 25
TWF2 twinfilin actin binding protein 2
VASP vasodilator-stimulated phosphoprotein
VAV1 vav 1 guanine nucleotide exchange factor
WDR4 WD repeat domain 4
WDR82 WD repeat domain 82
ZBTB25 zinc finger and BTB domain containing 25
ZFHX2 zinc finger homeobox 2
ZNF37BP zinc finger protein 37B, pseudogene
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862