fenspiride-6001 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fenspiride-6001 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACE2 angiotensin I converting enzyme 2
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADAM12 ADAM metallopeptidase domain 12
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALOX15 arachidonate 15-lipoxygenase
APOLD1 apolipoprotein L domain containing 1
APOM apolipoprotein M
ARR3 arrestin 3, retinal (X-arrestin)
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNK cyclin K
CD1C CD1c molecule
CD58 CD58 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CGA glycoprotein hormones, alpha polypeptide
CLSTN3 calsyntenin 3
CNTN1 contactin 1
COL4A1 collagen, type IV, alpha 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DOCK6 dedicator of cytokinesis 6
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EPHB2 EPH receptor B2
ETV4 ets variant 4
EXTL3 exostosin-like glycosyltransferase 3
FCAR Fc fragment of IgA receptor
FLJ11710 uncharacterized protein FLJ11710
FSCN1 fascin actin-bundling protein 1
GFOD2 glucose-fructose oxidoreductase domain containing 2
GJA9 gap junction protein, alpha 9, 59kDa
GPM6B glycoprotein M6B
GSTP1 glutathione S-transferase pi 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HAP1 huntingtin-associated protein 1
HEG1 heart development protein with EGF-like domains 1
HLF hepatic leukemia factor
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IAPP islet amyloid polypeptide
IDS iduronate 2-sulfatase
IKZF4 IKAROS family zinc finger 4 (Eos)
INSR insulin receptor
IRF8 interferon regulatory factor 8
ITGB8 integrin, beta 8
ITM2C integral membrane protein 2C
JRK Jrk homolog (mouse)
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLF12 Kruppel-like factor 12
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LEPR leptin receptor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAGEA11 melanoma antigen family A11
MOCS1 molybdenum cofactor synthesis 1
MUC6 mucin 6, oligomeric mucus/gel-forming
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO15A myosin XVA
NCKIPSD NCK interacting protein with SH3 domain
NEURL1 neuralized E3 ubiquitin protein ligase 1
NOX1 NADPH oxidase 1
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
PBOV1 prostate and breast cancer overexpressed 1
PCNXL2 pecanex-like 2 (Drosophila)
PDLIM3 PDZ and LIM domain 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PML promyelocytic leukemia
PON1 paraoxonase 1
POU5F1B POU class 5 homeobox 1B
RAB40A RAB40A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RHBDD3 rhomboid domain containing 3
RIMS2 regulating synaptic membrane exocytosis 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SH3GL3 SH3-domain GRB2-like 3
SMAD5-AS1 SMAD5 antisense RNA 1
SPAG6 sperm associated antigen 6
SSPN sarcospan
STMN3 stathmin-like 3
SVIL supervillin
SZT2 seizure threshold 2 homolog (mouse)
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCF12 transcription factor 12
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TRIM21 tripartite motif containing 21
TSNAXIP1 translin-associated factor X interacting protein 1
UBXN1 UBX domain protein 1
USB1 U6 snRNA biogenesis 1
UTRN utrophin
WLS wntless Wnt ligand secretion mediator
YPEL1 yippee-like 1 (Drosophila)
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF646 zinc finger protein 646

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ADAM23 ADAM metallopeptidase domain 23
ADGRE5 adhesion G protein-coupled receptor E5
ALPK1 alpha-kinase 1
ALS2CL ALS2 C-terminal like
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B9D2 B9 protein domain 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCOR BCL6 corepressor
BGLAP bone gamma-carboxyglutamate (gla) protein
C11ORF80 chromosome 11 open reading frame 80
C7ORF43 chromosome 7 open reading frame 43
CAMTA2 calmodulin binding transcription activator 2
CCDC88C coiled-coil domain containing 88C
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDON cell adhesion associated, oncogene regulated
CFD complement factor D (adipsin)
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLSPN claspin
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRYZL1 crystallin, zeta (quinone reductase)-like 1
CXXC4 CXXC finger protein 4
DGAT1 diacylglycerol O-acyltransferase 1
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSPP dentin sialophosphoprotein
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
FADS2 fatty acid desaturase 2
FAIM Fas apoptotic inhibitory molecule
FAM120C family with sequence similarity 120C
FBXL15 F-box and leucine-rich repeat protein 15
FBXL6 F-box and leucine-rich repeat protein 6
FBXO31 F-box protein 31
GPC3 glypican 3
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H4F histone cluster 1, H4f
HMHA1 histocompatibility (minor) HA-1
HOXA4 homeobox A4
HOXC10 homeobox C10
HOXD11 homeobox D11
IFI6 interferon, alpha-inducible protein 6
IQSEC2 IQ motif and Sec7 domain 2
IRS1 insulin receptor substrate 1
KCNK15 potassium channel, two pore domain subfamily K, member 15
KDM5C lysine (K)-specific demethylase 5C
KIAA0319L KIAA0319-like
KIF18A kinesin family member 18A
KLF2 Kruppel-like factor 2
KREMEN2 kringle containing transmembrane protein 2
LIN7B lin-7 homolog B (C. elegans)
LNPEP leucyl/cystinyl aminopeptidase
LTC4S leukotriene C4 synthase
MAGEH1 melanoma antigen family H1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MRAS muscle RAS oncogene homolog
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOD1 nucleotide-binding oligomerization domain containing 1
NXPH4 neurexophilin 4
P3H1 prolyl 3-hydroxylase 1
PCDHGB5 protocadherin gamma subfamily B, 5
PGPEP1 pyroglutamyl-peptidase I
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PYCRL pyrroline-5-carboxylate reductase-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RBL1 retinoblastoma-like 1
RFXAP regulatory factor X-associated protein
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
RIN1 Ras and Rab interactor 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF126P1 ring finger protein 126 pseudogene 1
RNF2 ring finger protein 2
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SAV1 salvador family WW domain containing protein 1
SERGEF secretion regulating guanine nucleotide exchange factor
SLC10A3 solute carrier family 10, member 3
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC35F5 solute carrier family 35, member F5
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRR2B small proline-rich protein 2B
SSFA2 sperm specific antigen 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCTA T-cell leukemia translocation altered
TMEM104 transmembrane protein 104
TMEM127 transmembrane protein 127
TMEM209 transmembrane protein 209
TRAIP TRAF interacting protein
UBQLN4 ubiquilin 4
ZBTB48 zinc finger and BTB domain containing 48
ZMAT5 zinc finger, matrin-type 5
ZNF767P zinc finger family member 767, pseudogene
ZNRD1-AS1 ZNRD1 antisense RNA 1