fgf2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description fibroblast growth factor 2 (basic)|The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2247)
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Genes

122 genes co-occuring with the biological term fgf2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
A2M alpha-2-macroglobulin
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANOS1 anosmin 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BAG3 BCL2-associated athanogene 3
BDNF brain-derived neurotrophic factor
BIRC5 baculoviral IAP repeat containing 5
BMP4 bone morphogenetic protein 4
BMPR1B bone morphogenetic protein receptor, type IB
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CRYAB crystallin, alpha B
CSNK2B casein kinase 2, beta polypeptide
CXCL12 chemokine (C-X-C motif) ligand 12
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DIABLO diablo, IAP-binding mitochondrial protein
EGF epidermal growth factor
EGR1 early growth response 1
F2 coagulation factor II (thrombin)
FES FES proto-oncogene, tyrosine kinase
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF18 fibroblast growth factor 18
FGF2 fibroblast growth factor 2 (basic)
FGFBP1 fibroblast growth factor binding protein 1
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FOS FBJ murine osteosarcoma viral oncogene homolog
GDNF glial cell derived neurotrophic factor
GPC1 glypican 1
GREM1 gremlin 1, DAN family BMP antagonist
GSK3B glycogen synthase kinase 3 beta
HBEGF heparin-binding EGF-like growth factor
HDAC5 histone deacetylase 5
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HPSE heparanase
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPG2 heparan sulfate proteoglycan 2
IBSP integrin-binding sialoprotein
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IL17RD interleukin 17 receptor D
IL1B interleukin 1, beta
IL6R interleukin 6 receptor
INHBA inhibin, beta A
JUN jun proto-oncogene
KDR kinase insert domain receptor
KL klotho
LACRT lacritin
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MIR152 microRNA 152
MIR503 microRNA 503
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MZF1 myeloid zinc finger 1
NAMPT nicotinamide phosphoribosyltransferase
NANOG Nanog homeobox
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGF nerve growth factor (beta polypeptide)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NRP1 neuropilin 1
NTF3 neurotrophin 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PF4 platelet factor 4
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLCG1 phospholipase C, gamma 1
PRKCA protein kinase C, alpha
PRMT5 protein arginine methyltransferase 5
PTGFR prostaglandin F receptor (FP)
PTN pleiotrophin
PTTG1 pituitary tumor-transforming 1
PTX3 pentraxin 3, long
REM2 RAS (RAD and GEM)-like GTP binding 2
RPL29 ribosomal protein L29
RUNX2 runt-related transcription factor 2
S100B S100 calcium binding protein B
SDC1 syndecan 1
SDC4 syndecan 4
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLIT2 slit homolog 2 (Drosophila)
SMN1 survival of motor neuron 1, telomeric
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOD1 superoxide dismutase 1, soluble
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STC1 stanniocalcin 1
SULF2 sulfatase 2
TEC tec protein tyrosine kinase
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNS4 tensin 4
TP53 tumor protein p53
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
YY1 YY1 transcription factor