fgfr1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description fibroblast growth factor receptor 1|The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2260)
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Genes

76 genes co-occuring with the biological term fgfr1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANOS1 anosmin 1
ARRB2 arrestin, beta 2
BAG4 BCL2-associated athanogene 4
BCR breakpoint cluster region
BMP4 bone morphogenetic protein 4
CCND1 cyclin D1
CDC73 cell division cycle 73
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEP350 centrosomal protein 350kDa
CHD7 chromodomain helicase DNA binding protein 7
CNTRL centriolin
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DDHD2 DDHD domain containing 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP3 fatty acid binding protein 3, muscle and heart
FGF10 fibroblast growth factor 10
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF21 fibroblast growth factor 21
FGF3 fibroblast growth factor 3
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FGFR1OP FGFR1 oncogene partner
FGFR1OP2 FGFR1 oncogene partner 2
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FLRT1 fibronectin leucine rich transmembrane protein 1
FLT1 fms-related tyrosine kinase 1
FOXO1 forkhead box O1
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRHR gonadotropin-releasing hormone receptor
GPC1 glypican 1
GRB14 growth factor receptor-bound protein 14
HPSE heparanase
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
JUN jun proto-oncogene
KDR kinase insert domain receptor
KISS1R KISS1 receptor
KLB klotho beta
KLF10 Kruppel-like factor 10
LDHA lactate dehydrogenase A
MIR149 microRNA 149
MIR198 microRNA 198
MIR214 microRNA 214
MIR424 microRNA 424
MUC4 mucin 4, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAM1 neural cell adhesion molecule 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFASC neurofascin
NOG noggin
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PLAG1 pleiomorphic adenoma gene 1
PROKR2 prokineticin receptor 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
S100B S100 calcium binding protein B
SDC1 syndecan 1
SOX2 SRY (sex determining region Y)-box 2
TBXA2R thromboxane A2 receptor
TEAD4 TEA domain family member 4
TGFB1 transforming growth factor, beta 1
TGFBR3 transforming growth factor, beta receptor III
TIMP2 TIMP metallopeptidase inhibitor 2
TP53 tumor protein p53
TPR translocated promoter region, nuclear basket protein
VEGFA vascular endothelial growth factor A
WNT1 wingless-type MMTV integration site family, member 1
ZNF703 zinc finger protein 703