fgfr2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description fibroblast growth factor receptor 2|The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] (NCBI Entrez Gene Database, 2263)
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Genes

59 genes co-occuring with the biological term fgfr2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPTL4 angiopoietin-like 4
BMP7 bone morphogenetic protein 7
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERCC1 excision repair cross-complementation group 1
ESRP1 epithelial splicing regulatory protein 1
ESRP2 epithelial splicing regulatory protein 2
FASTK Fas-activated serine/threonine kinase
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF2 fibroblast growth factor 2 (basic)
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FRS2 fibroblast growth factor receptor substrate 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GRB2 growth factor receptor-bound protein 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KDR kinase insert domain receptor
KRAS Kirsten rat sarcoma viral oncogene homolog
LDB1 LIM domain binding 1
LMO4 LIM domain only 4
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA3 melanoma antigen family A3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLCG1 phospholipase C, gamma 1
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RUNX2 runt-related transcription factor 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
STAT5A signal transducer and activator of transcription 5A
TGFB1 transforming growth factor, beta 1
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TP53 tumor protein p53
TP63 tumor protein p63
TWIST1 twist family bHLH transcription factor 1
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1