fgfr3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description fibroblast growth factor receptor 3|This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009] (NCBI Entrez Gene Database, 2261)
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Genes

56 genes co-occuring with the biological term fgfr3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID1A AT rich interactive domain 1A (SWI-like)
BRAF B-Raf proto-oncogene, serine/threonine kinase
CBX4 chromobox homolog 4
CCL3 chemokine (C-C motif) ligand 3
CCND1 cyclin D1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EGFR epidermal growth factor receptor
ETV6 ets variant 6
FGF2 fibroblast growth factor 2 (basic)
FGF3 fibroblast growth factor 3
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FOXN1 forkhead box N1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HRAS Harvey rat sarcoma viral oncogene homolog
IGF2 insulin-like growth factor 2
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT20 keratin 20, type I
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LMAN1 lectin, mannose-binding, 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR100 microRNA 100
MIR99A microRNA 99a
MUC1 mucin 1, cell surface associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCG1 phospholipase C, gamma 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SHOX short stature homeobox
SNRPE small nuclear ribonucleoprotein polypeptide E
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5B signal transducer and activator of transcription 5B
TACC1 transforming, acidic coiled-coil containing protein 1
TACC3 transforming, acidic coiled-coil containing protein 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TWIST1 twist family bHLH transcription factor 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta