fhl2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description four and a half LIM domains 2|This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 2274)
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Genes

34 genes co-occuring with the biological term fhl2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAM9 ADAM metallopeptidase domain 9
AHR aryl hydrocarbon receptor
AR androgen receptor
BRCA1 breast cancer 1, early onset
CCL19 chemokine (C-C motif) ligand 19
CD5 CD5 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
E4F1 E4F transcription factor 1
FHL2 four and a half LIM domains 2
FHL3 four and a half LIM domains 3
FOXO1 forkhead box O1
HIPK2 homeodomain interacting protein kinase 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
ITGA7 integrin, alpha 7
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
PELP1 proline, glutamate and leucine rich protein 1
PTK2 protein tyrosine kinase 2
RNF111 ring finger protein 111
SIRT1 sirtuin 1
SMAD4 SMAD family member 4
SRF serum response factor (c-fos serum response element-binding transcription factor)
TCF3 transcription factor 3
TGFB1 transforming growth factor, beta 1
TP53 tumor protein p53
TTN titin
VEGFA vascular endothelial growth factor A